Ethical approval and consent to participate
The study protocol was approved by the ethics committees of Fuxing Hospital, Capital Medical University (approval notice number 2013FXHEC-KY018) and all other centers. The Institutional Review Board specifically approved the informed consent waiver because of the anonymous and purely observational nature of this study.
Consent for publication
Not applicable.
Availability of data and materials
The datasets generated during the current study are available in the China Critical Care Sepsis Trial (CCCST) workgroup repository.
Competing interests
The authors have no competing interests to declare.
Funding
This study was supported by the National Science and Technology Supporting Plan of the Ministry of Science and Technology of the People’s Republic of China (2012BAI11B05). The funding source had no role in writing the manuscript or the decision to submit it for publication.
Authors’ contributions
MW and BZ designed and carried out the study, performed the statistical analysis, and drafted the manuscript. LJ, YW and BD was involved in design and in acquisition of data and helped to revise the manuscript critically for important content. WL was involved in the design and cleaning data. GL, WL, JW helped statistical analysis. The China Critical Care Sepsis Trial (CCCST) workgroup participated in acquisition and interpretation of data. YH was involved in the design, statistical analysis and revised the paper. XMX was the chief investigator, designed the CCCST, secured funding, contributed to writing the manuscript, and critically revised the paper. All authors read and critically revised the protocol and this article prior to submission.
Acknowledgments
We gratefully acknowledge the National Science and Technology Supporting Plan of the Ministry of Science and Technology of the People’s Republic of China, a government fund used to improve health-care quality and data collection, for providing financial support. We also acknowledge all the following members of the CCCST workgroup who contributed data and samples and have enabled this study to be conducted: Bin Du, Medical Intensive Care Unit, Peking Union Medical College Hospital, Beijing, China; Li Weng, Medical Intensive Care Unit, Peking Union Medical College Hospital, Beijing, China; Tong Li, Department of Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Meili Duan, Department of Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing China; Wenxiong Li, Surgical Intensive Care Unit, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Bing Sun, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Jianxin Zhou, Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Jianguo Jia, Surgical Intensive Care Unit, Xuanwu Hospital, Capital Medical University, Beijing, China; Xi Zhu, Department of Critical Care Medicine, Peking University Third Hospital, Beijing, China; Qingyuan Zhan, Department of Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; Xiaochun Ma, Department of Critical Care Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China; Tiehe Qin and Shouhong Wang, Department of Critical Care Medicine, Guangdong Geriatric Institute, Guangdong General Hospital, Guangdong, China; Yuhang Ai, Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China; Yan Kang and Xuelian Liao, Department of Critical Care Medicine, West China Hospital, Sichuan University, Sichuan, China; Xiangyuan Cao, Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Ningxia, China; Yushan Wang, Intensive Care Unit, The First Hospital of Jilin University, Changchun, China; and Duming Zhu, Surgical Intensive Care Unit, Department of Anaesthesiology, ZhongShan Hospital, FuDan University, Shanghai, China.
Authors' information
1Department of Epidemiology and Health Statistics,School of Public Health,Capital Medical University, NO.10 Xitoutiao, Youanmen, Fengtai District, Beijing 100069, China; 2Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, NO.20 Fuxingmenwai Street, Xicheng District, Beijing 100038, China; 3Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University, NO.45 Changchun Street, Xicheng District, Beijing, 100053, China; 4Beitaipingzhuang Community Health Service Centre, Haidian District, Beijing 100038, China. 5Medical Intensive Care Unit, Peking Union Medical College Hospital, NO.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China.