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The association between symptoms of depression during pregnancy and low birth weight:a prospective study

Xiu xiu Li, Rui Gao, Xiaowei Dai, Hong Liu, Jinxin Zhang, Xuemei Liu, Dongmei Si, Te Deng, Wei Xia

Abstract

Background

To identify whether prenatal depression is a risk factor of low birth weight (LBW) in a Chinese population.

Methods

1377 singleton pregnant women were recruited from Nanshan Maternity & Child Healthcare Hospital of Shenzhen in this prospective cohort study. Depression scales were assessed by the Edinburgh postnatal depression scale (EPDS) questionnaire in the second trimester of gestation; cut-points for the indication of prenatal depression were ≥12 scores in this study. Sociodemographic data, life-style and pregnancy outcomes were collected through Shenzhen Maternity & Child Healthcare database. The risks of adverse outcomes in patients with depression were determined by multivariate logistic regression and represented as odds ratios (ORs) and 95% confidence intervals (CIs).

Results

Of 1377 subjects, the prevalence of prenatal depression was 19.1%. The EPDS scores were 14.7±7.8and6.5±2.9 (P<0.001) in subjects with and without prenatal depression, respectively. After adjustment for maternal age, education, parity, pre-pregnancy body mass index (BMI), residential area, passive smoking conditions,fetal gender and other confounders, an EPDS score≥12 (versus. <12) was associated withanincreased risk for LBW (odds ratio: 2.05, 95% CI: 1.12-4.64).

Conclusion

Pregnant women presenting antenatal depressive symptoms are at elevated risk of low birth weight.

Keywords
Prenatal Depression, Low Birth Weight

Background

Materials and methods

Results

Discussion

Conclusion

Abbreviations

Declarations

References

Tables

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Preprint: Please note that this article has not completed peer review.

The association between symptoms of depression during pregnancy and low birth weight:a prospective study

Xiu xiu Li, Rui Gao, Xiaowei Dai, Hong Liu, Jinxin Zhang, Xuemei Liu, Dongmei Si, Te Deng, Wei Xia

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Abstract

Background

To identify whether prenatal depression is a risk factor of low birth weight (LBW) in a Chinese population.

Methods

1377 singleton pregnant women were recruited from Nanshan Maternity & Child Healthcare Hospital of Shenzhen in this prospective cohort study. Depression scales were assessed by the Edinburgh postnatal depression scale (EPDS) questionnaire in the second trimester of gestation; cut-points for the indication of prenatal depression were ≥12 scores in this study. Sociodemographic data, life-style and pregnancy outcomes were collected through Shenzhen Maternity & Child Healthcare database. The risks of adverse outcomes in patients with depression were determined by multivariate logistic regression and represented as odds ratios (ORs) and 95% confidence intervals (CIs).

Results

Of 1377 subjects, the prevalence of prenatal depression was 19.1%. The EPDS scores were 14.7±7.8and6.5±2.9 (P<0.001) in subjects with and without prenatal depression, respectively. After adjustment for maternal age, education, parity, pre-pregnancy body mass index (BMI), residential area, passive smoking conditions,fetal gender and other confounders, an EPDS score≥12 (versus. <12) was associated withanincreased risk for LBW (odds ratio: 2.05, 95% CI: 1.12-4.64).

Conclusion

Pregnant women presenting antenatal depressive symptoms are at elevated risk of low birth weight.

Background

Materials and methods

Results

Discussion

Conclusion

Abbreviations

Declarations

References

Tables

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