Preprint: Please note that this article has not completed peer review.

RECENT INCREASE IN COLISTIN-RESISTANT EXTENSIVELY DRUG RESISTANT ACINETOBACTER INFECTIONS AT A TERTIARY CARE CENTER IN PAKISTAN

Nosheen Nasir, Fatima Sharif, Rubab Mansoor, Shehryar Ahmed, Bushra Jamil, Faisal Mahmood
DOI: 10.21203/rs.2.11662/v1

Abstract

Background

Acinetobacter is an important nosocomial pathogen and a major cause of morbidity and mortality in hospitalized patients. Recently, colistin resistant strains of Acinetobacter were reported from different parts of the world. We are describing a case series of 18 patients with colistin resistant Acinetobacter over a span of 4 years.

Methods

Patients with any clinical specimen positive for colistin resistant Acinetobacter from 2014 to 2017 were identified from the hospital records. Three cases were isolated between 2014 and 2015, six cases in 2016 and 9 cases in 2017. Data on patients’ demographics as well as clinical data was collected retrospectively on a structured proforma from the hospital medical records.

Results

Mean age of the patients was 50 ± 18 years. Fifteen (83.3%) out of the 18 patients were male. Acinetobacter Pneumonia was the most common diagnosis in n=13(72.2% of the patients). Nine (50%) of the patients developed sepsis. In addition to Colistin resistance, carbapenem and amikacin resistance was documented to be 94% and 61% respectively. Colistin and carbapenem based combinations were used to treat all patients with a mean antibiotic duration of 20 ± 10 days. Median length of hospital stay was 25 days (range 8 - 61), with 14 patients (77.8%) requiring ICU admission. Eight (44.4%) of the patients expired and only 6 (33.3%) achieved microbiological eradication.

Conclusion

Infections due to Colistin resistant strains of Acinetobacter are rapidly increasing, have limited antimicrobial treatment options and are associated with poor outcomes.

Keywords
Acinetobacter, Multi-drug resistance, Colistin

Figures

BACKGROUND

METHODS

RESULTS

DISCUSSION

LIST OF ABBREVIATIONS

DECLARATIONS

REFERENCES

Tables

Comments (0)

Comments can take the form of short reviews, notes or questions to the author. Comments will be posted immediately, but removed and moderated if flagged.

Learn more about our company.

Preprint: Please note that this article has not completed peer review.

RECENT INCREASE IN COLISTIN-RESISTANT EXTENSIVELY DRUG RESISTANT ACINETOBACTER INFECTIONS AT A TERTIARY CARE CENTER IN PAKISTAN

Nosheen Nasir, Fatima Sharif, Rubab Mansoor, Shehryar Ahmed, Bushra Jamil, Faisal Mahmood

STATUS: In Review

Comments: 0
PDF Downloads: 0
HTML Views: 3

Integrity Check:

  • Article

  • Peer Review Timeline

  • Related Articles

  • Comments

Abstract

Background

Acinetobacter is an important nosocomial pathogen and a major cause of morbidity and mortality in hospitalized patients. Recently, colistin resistant strains of Acinetobacter were reported from different parts of the world. We are describing a case series of 18 patients with colistin resistant Acinetobacter over a span of 4 years.

Methods

Patients with any clinical specimen positive for colistin resistant Acinetobacter from 2014 to 2017 were identified from the hospital records. Three cases were isolated between 2014 and 2015, six cases in 2016 and 9 cases in 2017. Data on patients’ demographics as well as clinical data was collected retrospectively on a structured proforma from the hospital medical records.

Results

Mean age of the patients was 50 ± 18 years. Fifteen (83.3%) out of the 18 patients were male. Acinetobacter Pneumonia was the most common diagnosis in n=13(72.2% of the patients). Nine (50%) of the patients developed sepsis. In addition to Colistin resistance, carbapenem and amikacin resistance was documented to be 94% and 61% respectively. Colistin and carbapenem based combinations were used to treat all patients with a mean antibiotic duration of 20 ± 10 days. Median length of hospital stay was 25 days (range 8 - 61), with 14 patients (77.8%) requiring ICU admission. Eight (44.4%) of the patients expired and only 6 (33.3%) achieved microbiological eradication.

Conclusion

Infections due to Colistin resistant strains of Acinetobacter are rapidly increasing, have limited antimicrobial treatment options and are associated with poor outcomes.

Figures

BACKGROUND

METHODS

RESULTS

DISCUSSION

LIST OF ABBREVIATIONS

DECLARATIONS

REFERENCES

Tables

Learn more about our company.