1.Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, Charlson FJ, Norman RE, Flaxman AD, Johns N: Global burden of disease attributable to mental and substance use disorders. 2016.
2.Rush AJ, Fava M, Wisniewski SR, Lavori PW, Trivedi MH, Sackeim HA, Thase ME, Nierenberg AA, Quitkin FM, Kashner TM et al: Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design. Controlled clinical trials 2004, 25(1):119–142.
3.Sullivan PF, Neale MC, Kendler KS: Genetic epidemiology of major depression: Review and meta-analysis. American Journal of Psychiatry 2000, 157(10):1552.
4.Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG: Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Archives of general psychiatry 2010, 67(3):220–229.
5.Comings DE, Gade R, Macmurray JP, Muhleman D, Peters WR: Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric symptoms, and interaction with the dopamine D2 receptor (DRD2) gene. Molecular Psychiatry 1996, 1(4):325.
6.Black DW, Goldstein RB, Mason EE, Bell SE, Blum N: Depression and other mental disorders in the relatives of morbidly obese patients. Journal of Affective Disorders 1992, 25(2):91.
7.Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: “Positional cloning of the mouse obese gene and its human homologue”: Correction. Nature 1994, 372(6505):425–432.
8.Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM: Leptin enters the brain by a saturable system independent of insulin. Peptides 1996, 17(2):305–311.
9.Farr OM, Tsoukas MA, Mantzoros CS: Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders. Metabolism-clinical & Experimental 2015, 64(1):114–130.
10.Lu XY: The leptin hypothesis of depression: a potential link between mood disorders and obesity? Current Opinion in Pharmacology 2007, 7(6):648–652.
11.Zupancic ML, Mahajan A: Leptin as a neuroactive agent. Psychosomatic Medicine 2011, 73(5):407–414.
12.Lu XY, Kim CS, Frazer A, Zhang W: Leptin: a potential novel antidepressant. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(5):1593–1598.
13.Antonijevic IA, Murck H, Frieboes RM, Horn R, Brabant G, Steiger A: Elevated nocturnal profiles of serum leptin in patients with depression. Journal of Psychiatric Research 1998, 32(6):403.
14.Kraus T, Haack M, Schuld A, Hinze-Selch D, Pollmächer T: Low leptin levels but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology 2001, 73(4):243–247.
15.Jow GM, Yang TT, Chen CL: Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. J Affect Disord 2006, 90(1):21–27.
16.Pancheri P, Picardi A, Pasquini M, Gaetano P, Biondi M: Psychopathological dimensions of depression: a factor study of the 17-item Hamilton depression rating scale in unipolar depressed outpatients. J Affect Disord 2002, 68(1):41–47.
17.Koch CE, Lowe C, Pretz D, Steger J, Williams LM, Tups A: High-fat diet induces leptin resistance in leptin-deficient mice. Journal of neuroendocrinology 2014, 26(2):58–67.
18.Jow GM, Yang TT, Chen CL: Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. J Affect Disord 2006, 90(1):21–27.
19.Kraus T, Haack M, Schuld A, Hinze-Selch D, Pollmacher T: Low leptin levels but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology 2001, 73(4):243–247.
20.Jimenez I, Sobrino T, Rodriguez-Yanez M, Pouso M, Cristobo I, Sabucedo M, Blanco M, Castellanos M, Leira R, Castillo J: High serum levels of leptin are associated with post-stroke depression. Psychological medicine 2009, 39(7):1201–1209.
21.Zeman M, Jirak R, Jachymova M, Vecka M, Tvrzicka E, Zak A: Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women. Neuro endocrinology letters 2009, 30(3):387–395.
22.Antonijevic IA, Murck H, Frieboes RM, Horn R, Brabant G, Steiger A: Elevated nocturnal profiles of serum leptin in patients with depression. J Psychiatr Res 1998, 32(6):403–410.
23.Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K et al: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. 1999. Biochemical and biophysical research communications 2012, 425(3):560–564.
24.Fulda S, Linseisen J, Wolfram G, Himmerich S, Gedrich K, Pollmacher T, Himmerich H: Leptin plasma levels in the general population: influence of age, gender, body weight and medical history. Protein and peptide letters 2010, 17(11):1436–1440.
25.Cao B, Chen Y, Brietzke E, Cha D, Shaukat A, Pan Z, Park C, Subramaniapillai M, Zuckerman H, Grant K et al: Leptin and adiponectin levels in major depressive disorder: A systematic review and meta-analysis. J Affect Disord 2018, 238:101–110.
26.Zupancic ML, Mahajan A: Leptin as a neuroactive agent. Psychosom Med 2011, 73(5):407–414.
27.Chirinos DA, Goldberg R, Gellman M, Mendez AJ, Gutt M, McCalla JR, Llabre MM, Schneiderman N: Leptin and its association with somatic depressive symptoms in patients with the metabolic syndrome. Annals of behavioral medicine: a publication of the Society of Behavioral Medicine 2013, 46(1):31–39.
28.Labad J, Price JF, Strachan MW, Fowkes FG, Deary IJ, Seckl JR, Walker BR, Sattar N, Reynolds RM: Leptin levels and depressive symptoms in people with type 2 diabetes: the edinburgh type 2 diabetes study. Psychosom Med 2012, 74(1):39–45.
29.Yamada N, Katsuura G, Ochi Y, Ebihara K, Kusakabe T, Hosoda K, Nakao K: Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology 2011, 152(7):2634–2643.
30.Liu J, Garza JC, Bronner J, Kim CS, Zhang W, Lu XY: Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine. Psychopharmacology (Berl) 2010, 207(4):535–545.