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Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

Longhuan Zeng, Xueying Cai, Jiayi Chen, Guangyong Jin, Yongke Zheng

Abstract

Purpose

Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) during pregnancy is a rare but severe disease with high maternal-fetal mortality risk, which constitutes a systemic inflammatory process accompanied by thrombosis and bleeding disorders. However, the role of mean platelet volume (MPV) in HTG-AP during pregnancy remains unclear. This study aimed to assess the role of MPV and the potential relationship with disease severity in HTG-AP during pregnancy.

Methods

In the retrospective study, we collected 45 patients with HTG-AP during pregnancy as the HTG-AP group and 49 pregnant females with hypertriglyceridemia as the control group. MPV and other relevant variables at onset and remission were collected and compared.

Results

MPV levels were significantly higher in the HTG-AP group than in the control group (P < 0.001), and lower in remission than on onset (P = 0.002). According to the severity of acute pancreatitis, all subjects were classified into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups. There was a significant difference in MPV on onset among the three groups (P = 0.048), and the SAP patients had the highest levels of MPV. In addition, only in the SAP group, MPV was lower in remission than on onset (P = 0.010).

Conclusion

These results may indicate an important role of MPV in evaluating the severity of HTG-AP during pregnancy.

Keywords
Hypertriglyceridemia-induced acute pancreatitis, Pregnancy, Mean platelet volume, Diagnosis, Severity

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Methods

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Discussion

Conclusions

Abbreviations

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Preprint: Please note that this article has not completed peer review.

Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

Longhuan Zeng, Xueying Cai, Jiayi Chen, Guangyong Jin, Yongke Zheng

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Abstract

Purpose

Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) during pregnancy is a rare but severe disease with high maternal-fetal mortality risk, which constitutes a systemic inflammatory process accompanied by thrombosis and bleeding disorders. However, the role of mean platelet volume (MPV) in HTG-AP during pregnancy remains unclear. This study aimed to assess the role of MPV and the potential relationship with disease severity in HTG-AP during pregnancy.

Methods

In the retrospective study, we collected 45 patients with HTG-AP during pregnancy as the HTG-AP group and 49 pregnant females with hypertriglyceridemia as the control group. MPV and other relevant variables at onset and remission were collected and compared.

Results

MPV levels were significantly higher in the HTG-AP group than in the control group (P < 0.001), and lower in remission than on onset (P = 0.002). According to the severity of acute pancreatitis, all subjects were classified into mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP) groups. There was a significant difference in MPV on onset among the three groups (P = 0.048), and the SAP patients had the highest levels of MPV. In addition, only in the SAP group, MPV was lower in remission than on onset (P = 0.010).

Conclusion

These results may indicate an important role of MPV in evaluating the severity of HTG-AP during pregnancy.

Figures

Background

Methods

Results

Discussion

Conclusions

Abbreviations

Declarations

References

Tables

Learn more about our company.