Ethics approval and consent to participation:
DELCODE and DELCODE-PET were approved by the institutional review boards of all participating sites (Charité Berlin, Bonn, Cologne, Ludwig-Maximilians-University Munich, Rostock, and Tübingen), and coordinated by the ethics committee of the medical faculty of the University of Bonn, under the registration numbers: 117/13 (DELCODE) and 221/13 (DELCODE-PET). DELCODE-PET was also approved by the federal radiation protection authority (Bundesamt für Strahlenschutz). All procedures were performed in accordance with the relevant guidelines and regulations. All participants provided written informed consent.
Consent for publication:
Availability of data and materials:
The data which support this study are not publicly available, but may be provided upon reasonable request.
KB is advisor for Biogen GmbH. The other authors report no conflicts of interest relevant for this study.
The study was funded by the German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE), Reference number BN012.
The analyses of the Florbetaben PET exams reported in this study are subject of a research agreement with Life Molecular Imaging.
The following authors contributed to the overall design and implementation of DELCODE-PET: HB, FJ, A. Spottke, MD, A. Schmitt, NR. The following authors were responsible for conducting the DELCODE and/ or DELCODE-PET study examinations at the respective sites: OP, EII, JP, EJS, CL, RB, JDH, A. Schneider, KF, ME, FCG, FJ, MT, AD, KB, CC, A. Rominger, BEW, SJT, IK, BJK, CL, MB, MR, KS. The following authors were responsible for methodological core data management and analyses: ED, LD, MW, SW, A. Ramirez. The following authors were responsible for the Florbetaben visual ratings: FCG, HB. The following authors were responsible for data analyses, data interpretation, and drafting of the manuscript: SL, MD, LS, HB. All authors read and approved the final manuscript.
The authors would like to thank the Max Delbrück Center for Molecular Medicine in the Helmholtz Society (MDC), the Center for Cognitive Neuroscience Berlin at the Freie Universität Berlin (CCNB) and, especially, the DELCODE participants and their families.
DELCODE Study Group:
S. Altenstein, H. Amthauer, A. Bader, M. Barkhoff, M. Beuth, H. Boecker, F. Brosseron, K. Brüggen, M. Buchmann, K. Buerger, C. Catak, L. Coloma Andrews, M. Daamen, S. de Jonge, M. Dichgans, A. Dörr, M. Dyrba, M. Ehrlich, T. Engels, B. Ertl-Wagner, C. Escher, J. Faber, K. Fliessbach, D. Frimmer, I. Frommann, M. Fuentes , N. Ghiasi, D. Hauser, T. Heger, C. Heine, J. Henf, G. Hennes, G. Herrmann, P. Hinderer, B. Huber, A. Hufen, H. Janecek-Meyer, D. Janowitz, F. Jessen, K. Kafali, C. Kainz, P. Kalbhen, E. Kasper, I. Kilimann, X. Kobeleva, B. Kofler, C. Korp, M. Kreuzer, E. Kuder-Buletta, C. Kurz, A. Langenfurth , C. Laske, E. Lau, K. Lindner, A. Lohse, H. Lützerath, F. Maier, E. Markov, B. Marquardt, A. Martikke, H. Megges, D. Meiberth, F. Menne, L. Miebach, A. Müller, C. Müller, C. Mychajliw, O. Peters, H. Pfaff, A. Polcher, J. Priller, H. Raum, A. Rominger, S. Röske, A. Rostamzadeh, P. Sabik, Y. Sagik, P. Sänger, L. Sannemann, A.-K. Schild, J. Schmid, M. Schmidt, A. Schmitt, C. Schneider, A. Schneider, H. Schulz, S. Schwarzenboeck, A. Seegerer, S. Sorgalla, A. Spottke, E. J. Spruth, J. Stephan, A. Szagarus, S. J. Teipel, M. Thelen, M. Tscheuschler, I. Villar Munoz , I. Vogt, M. Wagner, M. Weber, S. Weschke, C. Westerteicher, C. Widmann, S. Wolfsgruber, A. Zollver.