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Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynecological malignancies: a randomized controlled trial

Jiawei Chen, Lin Tian, Le Zhang, Jianying Hu, Shaoqiang Huang, Jing Jiao
DOI: 10.21203/rs.2.12316/v1

Abstract

Background

The aim of this study was to compare the effects of nalbuphine and sufentanil on the gastrointestinal (GI) tract after laparoscopic surgery for gynecological malignancies.

Methods

A total of 100 patients aged between 18-70 years with American Society of Anesthesiologists (ASA) physical status I-II who scheduled for laparoscopic radical hysterectomy under general anaesthesia were enrolled. Patients were randomized to receive either sufentanil (Group S) or nalbuphine (Group N) to receive either sufentanil (Group S) or nalbuphine (Group N) in the intraoperative and postoperative periods. The time to the first passage of flatus, the time to the first defecation, the time to the toleration of diet, the serum gastrin and the length of hospital stay were compared between the groups. Postoperative pain by visual analogue scale (VAS), the number of PCA(patient-controlled analgesia)s, postoperative nausea and vomiting, and dizziness were compared between the groups.

Results

The time to the first passage of flatus(p =0.551), the time to the first defecation(p =0.310), the time to the toleration of diet(p =0.182), the serum gastrin(p =0.397), the number of postoperative nausea(p =0.920), vomit(p =0.334) and PCA events(p =0.167) and the length of hospital stay(p =0.482) were not significantly different between the two groups. VAS scores at postoperative 6 h(p=0.008), 12 h(p =0.002) and 24 h(p =0.013) were lower in Group N than in Group S.

Conclusions

Compared with sufentanil, nalbuphine was not associated with improved postoperative GI dysfunction after laparoscopic surgery for gynecological malignancies, but it was associated with reduced postoperative pain.

Keywords
Nalbuphine; postoperative gastrointestinal tract dysfunction; postoperative analgesia; RCT

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Conclusion

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Preprint: Please note that this article has not completed peer review.

Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynecological malignancies: a randomized controlled trial

Jiawei Chen, Lin Tian, Le Zhang, Jianying Hu, Shaoqiang Huang, Jing Jiao

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Abstract

Background

The aim of this study was to compare the effects of nalbuphine and sufentanil on the gastrointestinal (GI) tract after laparoscopic surgery for gynecological malignancies.

Methods

A total of 100 patients aged between 18-70 years with American Society of Anesthesiologists (ASA) physical status I-II who scheduled for laparoscopic radical hysterectomy under general anaesthesia were enrolled. Patients were randomized to receive either sufentanil (Group S) or nalbuphine (Group N) to receive either sufentanil (Group S) or nalbuphine (Group N) in the intraoperative and postoperative periods. The time to the first passage of flatus, the time to the first defecation, the time to the toleration of diet, the serum gastrin and the length of hospital stay were compared between the groups. Postoperative pain by visual analogue scale (VAS), the number of PCA(patient-controlled analgesia)s, postoperative nausea and vomiting, and dizziness were compared between the groups.

Results

The time to the first passage of flatus(p =0.551), the time to the first defecation(p =0.310), the time to the toleration of diet(p =0.182), the serum gastrin(p =0.397), the number of postoperative nausea(p =0.920), vomit(p =0.334) and PCA events(p =0.167) and the length of hospital stay(p =0.482) were not significantly different between the two groups. VAS scores at postoperative 6 h(p=0.008), 12 h(p =0.002) and 24 h(p =0.013) were lower in Group N than in Group S.

Conclusions

Compared with sufentanil, nalbuphine was not associated with improved postoperative GI dysfunction after laparoscopic surgery for gynecological malignancies, but it was associated with reduced postoperative pain.

Figures

Background

Methods

Results

Discussion

Conclusion

List of Abbreviations

Declarations

References

Tables

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