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Research article

53 Years Old is A Reasonable Cut-Off Value To Define Young And Old Patients In Clear Cell Renal Cell Carcinoma:A Study Based On TCGA And SEER Database

Fucai Tang, Zechao Lu, Chengwu He, Hanbin Zhang, Weijia Wu, Zhaohui He

Abstract

Background

The objectives of this study were to screen out cut-off age value and age-related differentially expressed genes (DEGs) in clear cell renal cell carcinoma (CCRCC) from Surveillance Epidemiology and End Results (SEER) database and The Cancer Genome Atlas (TCGA) database.

Methods

We selected 45,974 CCRCC patients from SEER and 530 RNA-seq data from TCGA database. The age cut-off value was defined using the X-tile program. Propensity score matching (PSM) was used to balance the differences between young and old groups. Hazard ratio (HR) was applied to evaluate prognostic risk of age in different subgroups. Age-related DEGs were identified via RNA-seq data. Survival analysis was used to assess the relationship between DEGs and prognosis.

Results

In this study, we divided the patients into young (n=14276) and old (n=31698) subgroups according to cut-off value (age=53). Age >53 years was indicated as independent risk factor for overall survival (OS) and cancer specific survival (CSS) of CCRCC before and after PSM. The prognosis of old group was worse than that in young group. 176 age-related DEGs were obtained by 530 CCRCC RNA-seq analysis result. The expression levels of KCNE5, CLDN6 and CACNG6 were related to prognosis of the elderly.

Conclusion

53 years old was cut-off value in CCRCC. The prognosis of the elderly was worse than young people. KCNE5, CLDN6 and CACNG6 were age-related differential genes which might play an important role in the poor prognosis of elderly CCRCC patients.

Keywords
Age; age-related genes; Clear cell renal cell carcinoma; The Cancer Genome Atlas; Surveillance Epidemiology and End Results

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Background

Methods

Results

Discussion

Conclusions

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References

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Preprint: Please note that this article has not completed peer review.
Research article

53 Years Old is A Reasonable Cut-Off Value To Define Young And Old Patients In Clear Cell Renal Cell Carcinoma:A Study Based On TCGA And SEER Database

Fucai Tang, Zechao Lu, Chengwu He, Hanbin Zhang, Weijia Wu, Zhaohui He

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Abstract

Background

The objectives of this study were to screen out cut-off age value and age-related differentially expressed genes (DEGs) in clear cell renal cell carcinoma (CCRCC) from Surveillance Epidemiology and End Results (SEER) database and The Cancer Genome Atlas (TCGA) database.

Methods

We selected 45,974 CCRCC patients from SEER and 530 RNA-seq data from TCGA database. The age cut-off value was defined using the X-tile program. Propensity score matching (PSM) was used to balance the differences between young and old groups. Hazard ratio (HR) was applied to evaluate prognostic risk of age in different subgroups. Age-related DEGs were identified via RNA-seq data. Survival analysis was used to assess the relationship between DEGs and prognosis.

Results

In this study, we divided the patients into young (n=14276) and old (n=31698) subgroups according to cut-off value (age=53). Age >53 years was indicated as independent risk factor for overall survival (OS) and cancer specific survival (CSS) of CCRCC before and after PSM. The prognosis of old group was worse than that in young group. 176 age-related DEGs were obtained by 530 CCRCC RNA-seq analysis result. The expression levels of KCNE5, CLDN6 and CACNG6 were related to prognosis of the elderly.

Conclusion

53 years old was cut-off value in CCRCC. The prognosis of the elderly was worse than young people. KCNE5, CLDN6 and CACNG6 were age-related differential genes which might play an important role in the poor prognosis of elderly CCRCC patients.

Figures

Background

Methods

Results

Discussion

Conclusions

Abbreviations

Declarations

References

Tables

Learn more about our company.