[1] J.M.M. Howson, W. Zhao, D.R. Barnes, W.K. Ho, R. Young, D.S. Paul, L.L. Waite, D.F. Freitag, E.B. Fauman, E.L. Salfati, B.B. Sun, J.D. Eicher, A.D. Johnson, W.H.H. Sheu, S.F. Nielsen, W.Y. Lin, P. Surendran, A. Malarstig, J.B. Wilk, A. Tybjaerg-Hansen, K.L. Rasmussen, P.R. Kamstrup, P. Deloukas, J. Erdmann, S. Kathiresan, N.J. Samani, H. Schunkert, H. Watkins, CardioGramplusC4D, R. Do, D.J. Rader, J.A. Johnson, S.L. Hazen, A.A. Quyyumi, J.A. Spertus, C.J. Pepine, N. Franceschini, A. Justice, A.P. Reiner, S. Buyske, L.A. Hindorff, C.L. Carty, K.E. North, C. Kooperberg, E. Boerwinkle, K. Young, M. Graff, U. Peters, D. Absher, C.A. Hsiung, W.J. Lee, K.D. Taylor, Y.H. Chen, I.T. Lee, X. Guo, R.H. Chung, Y.J. Hung, J.I. Rotter, J.J. Juang, T. Quertermous, T.D. Wang, A. Rasheed, P. Frossard, D.S. Alam, A.A.S. Majumder, E. Di Angelantonio, R. Chowdhury, C.V.D. Epic, Y.I. Chen, B.G. Nordestgaard, T.L. Assimes, J. Danesh, A.S. Butterworth, D. Saleheen, Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms, Nat Genet, 49 (2017) 1113-1119.
[2] J. Xu, S.L. Murphy, K.D. Kochanek, B.A. Bastian, Deaths: Final Data for 2013, National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System, 64 (2016) 1-119.
[3] D.P. Leong, P.G. Joseph, M. McKee, S.S. Anand, K.K. Teo, J.D. Schwalm, S. Yusuf, Reducing the Global Burden of Cardiovascular Disease, Part 2: Prevention and Treatment of Cardiovascular Disease, Circ Res, 121 (2017) 695-710.
[4] L. Jiang, H.M. Krumholz, X. Li, J. Li, S. Hu, Achieving best outcomes for patients with cardiovascular disease in China by enhancing the quality of medical care and establishing a learning health-care system, The Lancet, 386 (2015) 1493-1505.
[5] S. Arora, G.A. Stouffer, A.M. Kucharska-Newton, A. Qamar, M. Vaduganathan, A. Pandey, D. Porterfield, R. Blankstein, W.D. Rosamond, D.L. Bhatt, M.C. Caughey, Twenty Year Trends and Sex Differences in Young Adults Hospitalized With Acute Myocardial Infarction, Circulation, 139 (2019) 1047-1056.
[6] K.A. Wilmot, M. O'Flaherty, S. Capewell, E.S. Ford, V. Vaccarino, Coronary Heart Disease Mortality Declines in the United States From 1979 Through 2011: Evidence for Stagnation in Young Adults, Especially Women, Circulation, 132 (2015) 997-1002.
[7] M. O'Flaherty, E. Ford, S. Allender, P. Scarborough, S. Capewell, Coronary heart disease trends in England and Wales from 1984 to 2004: concealed levelling of mortality rates among young adults, Heart (British Cardiac Society), 94 (2008) 178-181.
[8] M. O'Flaherty, S. Allender, R. Taylor, C. Stevenson, A. Peeters, S. Capewell, The decline in coronary heart disease mortality is slowing in young adults (Australia 1976-2006): a time trend analysis, International journal of cardiology, 158 (2012) 193-198.
[9] M.K. Christiansen, J.M. Jensen, B.L. Norgaard, D. Dey, H.E. Botker, H.K. Jensen, Coronary Plaque Burden and Adverse Plaque Characteristics Are Increased in Healthy Relatives of Patients With Early Onset Coronary Artery Disease, JACC Cardiovasc Imaging, 10 (2017) 1128-1135.
[10] W.X. Yang, Z. Yang, Y.J. Wu, S.B. Qiao, Y.J. Yang, J.L. Chen, Factors associated with coronary artery disease in young population (age </= 40): analysis with 217 cases, Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 29 (2014) 38-42.
[11] S. Huang, C. Sun, Y. Hou, Y. Tang, Z. Zhu, Z. Zhang, Y. Zhang, L. Wang, Q. Zhao, M.G. Chen, Z. Guo, D. Wang, W. Ju, Q. Zhou, L. Wu, X. He, A comprehensive bioinformatics analysis on multiple Gene Expression Omnibus datasets of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, Sci Rep, 8 (2018) 7630.
[12] H.Q. Zhou, Q.C. Chen, Z.T. Qiu, W.L. Tan, C.Q. Mo, S.W. Gao, Integrative microRNA-mRNA and protein-protein interaction analysis in pancreatic neuroendocrine tumors, European review for medical and pharmacological sciences, 20 (2016) 2842-2852.
[13] W. Huang da, B.T. Sherman, R.A. Lempicki, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nature protocols, 4 (2009) 44-57.
[14] D. Szklarczyk, A. Franceschini, M. Kuhn, M. Simonovic, A. Roth, P. Minguez, T. Doerks, M. Stark, J. Muller, P. Bork, L.J. Jensen, C. von Mering, The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored, Nucleic Acids Res, 39 (2011) D561-568.
[15] D. Szklarczyk, J.H. Morris, H. Cook, M. Kuhn, S. Wyder, M. Simonovic, A. Santos, N.T. Doncheva, A. Roth, P. Bork, L.J. Jensen, C. von Mering, The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible, Nucleic Acids Res, 45 (2017) D362-D368.
[16] S.C. Jeyaraj, N.T. Unger, M.A. Chotani, Rap1 GTPases: an emerging role in the cardiovasculature, Life Sci, 88 (2011) 645-652.
[17] L. Stefanini, R.H. Lee, D.S. Paul, E.C. O'Shaughnessy, D. Ghalloussi, C.I. Jones, Y. Boulaftali, K.O. Poe, R. Piatt, D.O. Kechele, K.M. Caron, K.M. Hahn, J.M. Gibbins, W. Bergmeier, Functional redundancy between RAP1 isoforms in murine platelet production and function, Blood, (2018).
[18] P. Crocco, R. Barale, G. Rose, C. Rizzato, A. Santoro, F. De Rango, M. Carrai, P. Fogar, D. Monti, F. Biondi, L. Bucci, R. Ostan, F. Tallaro, A. Montesanto, C.F. Zambon, C. Franceschi, F. Canzian, G. Passarino, D. Campa, Population-specific association of genes for telomere-associated proteins with longevity in an Italian population, Biogerontology, 16 (2015) 353-364.
[19] N.J. Samani, R. Boultby, R. Butler, J.R. Thompson, A.H. Goodall, Telomere shortening in atherosclerosis, Lancet (London, England), 358 (2001) 472-473.
[20] P.M. Nilsson, H. Tufvesson, M. Leosdottir, O. Melander, Telomeres and cardiovascular disease risk: an update 2013, Translational research : the journal of laboratory and clinical medicine, 162 (2013) 371-380.
[21] D. Degl'Innocenti, R. Marzocchini, F. Malentacchi, M. Ramazzotti, G. Raugei, G. Ramponi, ACYP1 gene possesses two alternative splicing forms that induce apoptosis, IUBMB Life, 56 (2004) 29-33.
[22] Y. Hirata, M. Tabata, H. Kurobe, T. Motoki, M. Akaike, C. Nishio, M. Higashida, H. Mikasa, Y. Nakaya, S. Takanashi, T. Igarashi, T. Kitagawa, M. Sata, Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue, J Am Coll Cardiol, 58 (2011) 248-255.
[23] I. Ikonomidis, J. Lekakis, I. Revela, F. Andreotti, P. Nihoyannopoulos, Increased circulating C-reactive protein and macrophage-colony stimulating factor are complementary predictors of long-term outcome in patients with chronic coronary artery disease, Eur Heart J, 26 (2005) 1618-1624.
[24] A. Benard, I. Sakwa, P. Schierloh, A. Colom, I. Mercier, L. Tailleux, L. Jouneau, P. Boudinot, T. Al-Saati, R. Lang, J. Rehwinkel, A.G. Loxton, S.H.E. Kaufmann, V. Anton-Leberre, A. O'Garra, M.D.C. Sasiain, B. Gicquel, S. Fillatreau, O. Neyrolles, D. Hudrisier, B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis, Am J Respir Crit Care Med, 197 (2018) 801-813.
[25] M.C. Boshuizen, M.P. de Winther, Interferons as Essential Modulators of Atherosclerosis, Arteriosclerosis, thrombosis, and vascular biology, 35 (2015) 1579-1588.
[26] P. Goossens, M.J. Gijbels, A. Zernecke, W. Eijgelaar, M.N. Vergouwe, I. van der Made, J. Vanderlocht, L. Beckers, W.A. Buurman, M.J. Daemen, U. Kalinke, C. Weber, E. Lutgens, M.P. de Winther, Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions, Cell metabolism, 12 (2010) 142-153.
[27] P. Gordts, E.M. Foley, R. Lawrence, R. Sinha, C. Lameda-Diaz, L. Deng, R. Nock, C.K. Glass, A. Erbilgin, A.J. Lusis, J.L. Witztum, J.D. Esko, Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling, Cell metabolism, 20 (2014) 813-826.