Preprint: Please note that this article has not completed peer review.
Research article

ADHERENCE TO ANTIRETROVIRAL THERAPY AND ASSOCIATED FACTORS AMONG HIV POSITIVE ADULTS ATTENDING TREATMENT AT NEKEMTE REFERRAL HOSPITAL, WEST ETHIOPIA, 2019

Muktar Abadiga
DOI: 10.21203/rs.2.12737/v1

Abstract

BACK GROUND

Antiretroviral therapy has a remarkable clinical effect in decreasing the viral replication, reducing the progress of AIDS and deaths related to AIDS. The clinical outcome of ART depends on the strict adherence to antiretroviral medication. However; only a few studies have been done on the adherence status of ART and its determinant factors in Ethiopia and this study could provide an opportunity to identify obstacles to taking medication. Therefore, the purpose of this study was to assess adherence status and associated factors among HIV infected patients on ART attending Nekemte referral hospital, West Ethiopia.

METHODS

Institutional based cross-sectional study was conducted on 311 HIV/AIDS patients, from March 01 to March 30, 2019. The study participants were selected by simple random sampling method and were interviewed using structured questionnaires. The data were coded, checked, cleaned and entered into Epi data version 3.1 and then exported to SPSS window version 20.0 for analysis. Multivariable logistic regression was used to find the independent variables which best predict adherence. Association and statistical significance were measured using odds ratio at 95% confidence interval and p-value less than 0.05.

RESULTS

A total of 305 HIV/AIDS patients were included in this study. Out of this,73.1% were adhered to their medication. Respondent’s knowledge about HIV and its treatment (AOR=8.13, 95% CI: 3.06, 21.61), family/social support (AOR=7.36, 95% CI: 2.07, 26.10), adverse effects of ARV medications (AOR=5.62, 95% CI: 2.11, 14.93), co-morbidity of other chronic illness (AOR=5.46, 95% CI: 1.86, 16.02), and family disclosure status (AOR= 5.27, 95% CI: 2.20, 12.62) were significantly associated with adherence to medication among HIV/AIDS patients.

CONCLUSION

In this study, the level of adherence to antiretroviral therapy was found low compared to the WHO standard. The clinician should emphasize adverse drug reaction, early detect and treat co-morbidities, improve knowledge through health education, and encourage HIV/AIDS patient to disclose their HIV status.

Keywords
Adherence, Antiretroviral therapy, HIV/AIDS, Ethiopia

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Methods and Materials

Results

Discussion

Conclusions

Abbreviations

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Preprint: Please note that this article has not completed peer review.
Research article

ADHERENCE TO ANTIRETROVIRAL THERAPY AND ASSOCIATED FACTORS AMONG HIV POSITIVE ADULTS ATTENDING TREATMENT AT NEKEMTE REFERRAL HOSPITAL, WEST ETHIOPIA, 2019

Muktar Abadiga

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Abstract

BACK GROUND

Antiretroviral therapy has a remarkable clinical effect in decreasing the viral replication, reducing the progress of AIDS and deaths related to AIDS. The clinical outcome of ART depends on the strict adherence to antiretroviral medication. However; only a few studies have been done on the adherence status of ART and its determinant factors in Ethiopia and this study could provide an opportunity to identify obstacles to taking medication. Therefore, the purpose of this study was to assess adherence status and associated factors among HIV infected patients on ART attending Nekemte referral hospital, West Ethiopia.

METHODS

Institutional based cross-sectional study was conducted on 311 HIV/AIDS patients, from March 01 to March 30, 2019. The study participants were selected by simple random sampling method and were interviewed using structured questionnaires. The data were coded, checked, cleaned and entered into Epi data version 3.1 and then exported to SPSS window version 20.0 for analysis. Multivariable logistic regression was used to find the independent variables which best predict adherence. Association and statistical significance were measured using odds ratio at 95% confidence interval and p-value less than 0.05.

RESULTS

A total of 305 HIV/AIDS patients were included in this study. Out of this,73.1% were adhered to their medication. Respondent’s knowledge about HIV and its treatment (AOR=8.13, 95% CI: 3.06, 21.61), family/social support (AOR=7.36, 95% CI: 2.07, 26.10), adverse effects of ARV medications (AOR=5.62, 95% CI: 2.11, 14.93), co-morbidity of other chronic illness (AOR=5.46, 95% CI: 1.86, 16.02), and family disclosure status (AOR= 5.27, 95% CI: 2.20, 12.62) were significantly associated with adherence to medication among HIV/AIDS patients.

CONCLUSION

In this study, the level of adherence to antiretroviral therapy was found low compared to the WHO standard. The clinician should emphasize adverse drug reaction, early detect and treat co-morbidities, improve knowledge through health education, and encourage HIV/AIDS patient to disclose their HIV status.

Figures

Introduction

Methods and Materials

Results

Discussion

Conclusions

Abbreviations

Declarations

References

Tables

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