Production of packed nanospray emitters with integrated emitter-end frits for liquid-chromatography mass spectrometry
This protocol describes how to frit the emitter-end of a pulled silica capillary and subsequently pack it to produce a robust integrated column. Integrating liquid chromatography separations directly into the emitter of a nanospray source for mass spectrometry offers improved sensitivity and resolution. This is achieved by reducing post-separation dead volume. The method described here provides an optimized setup to maximize sensitivity and separation.
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Posted 02 Jan, 2018
Production of packed nanospray emitters with integrated emitter-end frits for liquid-chromatography mass spectrometry
Posted 02 Jan, 2018
This protocol describes how to frit the emitter-end of a pulled silica capillary and subsequently pack it to produce a robust integrated column. Integrating liquid chromatography separations directly into the emitter of a nanospray source for mass spectrometry offers improved sensitivity and resolution. This is achieved by reducing post-separation dead volume. The method described here provides an optimized setup to maximize sensitivity and separation.
Figure 1
Figure 2