This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Alireza Nourazarian
Tabriz University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2082-1335
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Stroke is one of the leading causes of death worldwide and has different characteristics. Different physiopathological mechanisms characterize the different subtypes of ischemic stroke. In this study, we investigated the correlation between serum levels of autophagy-5 protein, Apo-lipoprotein B-48, and oxidative stress markers in patients with ischemic stroke.
Methods and results: We enrolled 100 participants, including 50 ischemic stroke (IS) patients as the case group and 50 healthy individuals as the control group. Then, we conducted a case-control study at Imam Reza Hospital from March 2019 to April 2020. We quantified the serum levels of ATG5, Apo B-48, and oxidative stress markers in both groups. And we evaluated the incremental diagnostic value of these factors by receiver operating characteristic analysis (ROC) in both groups. The mean serum levels of ATG5, Apo B-48, and oxidative stress markers were higher in the case group than in the control group, with a p–value of less than 0.0001 (p <0.0001).
Conclusions: Serum levels of ATG5, Apo B-48, Malonaldehyde (MDA), total oxidative stress (TOS), and total antioxidant capacity (TAC) in patients with IS can be used as novel biomarkers to predict or therapeutically modulate patients with IS.
Keywords
Apo-lipoprotein B-48, Autophagy 5-protein, Ischemic stroke, Oxidative stress
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Alireza Nourazarian
Tabriz University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2082-1335
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 25 Oct, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Molecular Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Stroke is one of the leading causes of death worldwide and has different characteristics. Different physiopathological mechanisms characterize the different subtypes of ischemic stroke. In this study, we investigated the correlation between serum levels of autophagy-5 protein, Apo-lipoprotein B-48, and oxidative stress markers in patients with ischemic stroke.
Methods and results: We enrolled 100 participants, including 50 ischemic stroke (IS) patients as the case group and 50 healthy individuals as the control group. Then, we conducted a case-control study at Imam Reza Hospital from March 2019 to April 2020. We quantified the serum levels of ATG5, Apo B-48, and oxidative stress markers in both groups. And we evaluated the incremental diagnostic value of these factors by receiver operating characteristic analysis (ROC) in both groups. The mean serum levels of ATG5, Apo B-48, and oxidative stress markers were higher in the case group than in the control group, with a p–value of less than 0.0001 (p <0.0001).
Conclusions: Serum levels of ATG5, Apo B-48, Malonaldehyde (MDA), total oxidative stress (TOS), and total antioxidant capacity (TAC) in patients with IS can be used as novel biomarkers to predict or therapeutically modulate patients with IS.
Figure 1
Figure 2
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