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Research article
Muhammad Iqbal
King Saud University
Corresponding Author
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Background Bariatric surgery is an effective treatment for severe obesity. It also ameliorates diabetes independently of weight loss through mechanisms that are not fully understood. In this study, we investigated the levels of GH, IGF-1 and IGF-binding protein (IGFBP-2) after gastric sleeve surgery in healthy obese individuals.
Method This study was conducted in 33 obese (BMI >38.3) healthy male subjects aged 25 to 50 years undergoing sleeve gastrectomy. GH, IGF-1 and IGFBP-2 levels were evaluated by ELISA at baseline and 6-12 months after surgery. Other parameters, such as glucose, BMI, insulin, HOMA-IR and lipid profile, were also investigated.
Results Systemic GH (12.32 vs. 50.97 pg/mL, p < 0.001) and IGFBP-2 levels (51.86 vs. 68.81 pg/mL, p < 0.001) were elevated after bariatric surgery. There was no change in IGF-1 level from before to after surgery. BMI (52.18 vs. 40.11, p = 0.001), insulin (19.35 vs. 8.80 mIU/L, p < 0.001) and HOMA-IR index (6.48 to 2.52, p < 0.001) were reduced after surgery. Lipid profile analysis revealed that total cholesterol (4.26 vs. 5.12 mmol/L, p < 0.001) and high-density lipoprotein (HDL) (0.90 to 1.55 mmol/L, p < 0.001) were increased, while triglycerides were decreased, after surgery (1.62 vs. 1.05 mmol/L p < 0.001). GH, IGF-1, and IGFBP-2 were not correlated with insulin or lipid parameters.
Conclusions Our study suggests that improved circulating GH and IGFBP-2 levels may mediate the beneficial effects of gastric sleeve surgery in improving insulin sensitivity and reducing insulin demand.
Keywords
Gastric Sleeve Surgery, Growth Hormone, IGF-1, IGFBP-2, Obesity
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CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
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On 18 May, 2020
Editorial decision: Accept
On 18 May, 2020
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Editorial decision: Minor revision
On 14 May, 2020
Editor assigned
On 29 Apr, 2020
Editor invited
On 28 Apr, 2020
Submission checks complete
On 17 Dec, 2019
Version 2
Posted 24 Mar, 2020
No comments provided
Editorial decision: Minor revision
On 30 Mar, 2020
Review #2 received
Received 28 Mar, 2020
Review #1 received
Received 23 Mar, 2020
Reviewer #2 agreed
On 22 Mar, 2020
Reviewer #1 agreed
On 20 Mar, 2020
Editor assigned
On 19 Mar, 2020
Reviewers invited
Invitations sent on 19 Mar, 2020
Submission checks complete
On 18 Mar, 2020
Editor invited
On 18 Mar, 2020
No comments provided
Editorial decision: Major revision
On 06 Feb, 2020
Review #2 received
Received 25 Jan, 2020
Review #1 received
Received 17 Jan, 2020
Reviewer #2 agreed
On 02 Jan, 2020
Reviewers invited
Invitations sent on 30 Dec, 2019
Reviewer #1 agreed
On 30 Dec, 2019
Editor assigned
On 17 Dec, 2019
First submitted
On 16 Dec, 2019
Submission checks complete
On 16 Dec, 2019
Editor invited
On 16 Dec, 2019
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See the published version of this preprint at BMC Gastroenterology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Muhammad Iqbal
King Saud University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
No community comments so far
Submission checks complete
On 18 May, 2020
Editorial decision: Accept
On 18 May, 2020
No comments provided
Editorial decision: Minor revision
On 14 May, 2020
Editor assigned
On 29 Apr, 2020
Editor invited
On 28 Apr, 2020
Submission checks complete
On 17 Dec, 2019
Version 2
Posted 24 Mar, 2020
No comments provided
Editorial decision: Minor revision
On 30 Mar, 2020
Review #2 received
Received 28 Mar, 2020
Review #1 received
Received 23 Mar, 2020
Reviewer #2 agreed
On 22 Mar, 2020
Reviewer #1 agreed
On 20 Mar, 2020
Editor assigned
On 19 Mar, 2020
Reviewers invited
Invitations sent on 19 Mar, 2020
Submission checks complete
On 18 Mar, 2020
Editor invited
On 18 Mar, 2020
No comments provided
Editorial decision: Major revision
On 06 Feb, 2020
Review #2 received
Received 25 Jan, 2020
Review #1 received
Received 17 Jan, 2020
Reviewer #2 agreed
On 02 Jan, 2020
Reviewers invited
Invitations sent on 30 Dec, 2019
Reviewer #1 agreed
On 30 Dec, 2019
Editor assigned
On 17 Dec, 2019
First submitted
On 16 Dec, 2019
Submission checks complete
On 16 Dec, 2019
Editor invited
On 16 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Gastroenterology.
Background Bariatric surgery is an effective treatment for severe obesity. It also ameliorates diabetes independently of weight loss through mechanisms that are not fully understood. In this study, we investigated the levels of GH, IGF-1 and IGF-binding protein (IGFBP-2) after gastric sleeve surgery in healthy obese individuals.
Method This study was conducted in 33 obese (BMI >38.3) healthy male subjects aged 25 to 50 years undergoing sleeve gastrectomy. GH, IGF-1 and IGFBP-2 levels were evaluated by ELISA at baseline and 6-12 months after surgery. Other parameters, such as glucose, BMI, insulin, HOMA-IR and lipid profile, were also investigated.
Results Systemic GH (12.32 vs. 50.97 pg/mL, p < 0.001) and IGFBP-2 levels (51.86 vs. 68.81 pg/mL, p < 0.001) were elevated after bariatric surgery. There was no change in IGF-1 level from before to after surgery. BMI (52.18 vs. 40.11, p = 0.001), insulin (19.35 vs. 8.80 mIU/L, p < 0.001) and HOMA-IR index (6.48 to 2.52, p < 0.001) were reduced after surgery. Lipid profile analysis revealed that total cholesterol (4.26 vs. 5.12 mmol/L, p < 0.001) and high-density lipoprotein (HDL) (0.90 to 1.55 mmol/L, p < 0.001) were increased, while triglycerides were decreased, after surgery (1.62 vs. 1.05 mmol/L p < 0.001). GH, IGF-1, and IGFBP-2 were not correlated with insulin or lipid parameters.
Conclusions Our study suggests that improved circulating GH and IGFBP-2 levels may mediate the beneficial effects of gastric sleeve surgery in improving insulin sensitivity and reducing insulin demand.
Figure 1
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