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Case report
Lin Ma
Sichuan University West China Hospital
Corresponding Author
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Background: There were very few reports of atypical carcinoid in anterior mediastinum. Atypical carcinoids originating in the mediastinum belong to a neuroendocrine tumor (NET), which is also a very rare clinically aggressive mediastinal tumor.
Case presentation: We herein reported a rare case of NET of mediastinal origin and a review of several cases concerning the clinical and pathological features of this disease, which is often misdiagnosed as atypical carcinoid tumor in mediastinum. The tumor was removed by mid-sternal thoracotomy with superior vena cava formation, left common carotid artery resection and artificial blood vessel replacement, left upper lobe wedge resection, left phrenic nerve resection, left vagus nerve resection and partial pericardectomy.
Conclusions: To the best of our knowledge, this is the sixth atypical carcinoid occurring in mediastinum with proof via histology and IHC. Our findings suggest the difficulty of making a diagnosis before surgery and more cases will need to be reported in order to facilitate the preoperative diagnosis of such a rare tumor.
Keywords
Mediastinum, neuroendocrine tumor (NET), surgery, atypical carcinoid
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This preprint is under consideration at Journal of Cardiothoracic Surgery. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Case report
Lin Ma
Sichuan University West China Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 28 Oct, 2021
No community comments so far
Editor assigned
On 25 Oct, 2021
Submission checks complete
On 24 Oct, 2021
Editor invited
On 24 Oct, 2021
First submitted
On 21 Oct, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiothoracic Surgery
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: There were very few reports of atypical carcinoid in anterior mediastinum. Atypical carcinoids originating in the mediastinum belong to a neuroendocrine tumor (NET), which is also a very rare clinically aggressive mediastinal tumor.
Case presentation: We herein reported a rare case of NET of mediastinal origin and a review of several cases concerning the clinical and pathological features of this disease, which is often misdiagnosed as atypical carcinoid tumor in mediastinum. The tumor was removed by mid-sternal thoracotomy with superior vena cava formation, left common carotid artery resection and artificial blood vessel replacement, left upper lobe wedge resection, left phrenic nerve resection, left vagus nerve resection and partial pericardectomy.
Conclusions: To the best of our knowledge, this is the sixth atypical carcinoid occurring in mediastinum with proof via histology and IHC. Our findings suggest the difficulty of making a diagnosis before surgery and more cases will need to be reported in order to facilitate the preoperative diagnosis of such a rare tumor.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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