Guo[5]
|
2013
|
KDM6A, TP53, ARID1A, CREBBP, EP300, HRAS, RB1, PIK3CA, STAG2, FGFR3, SYNE1, KMT2A, KRAS, ERCC2, NF1, SYNE2, ELF3, ANK3, ESPL1, CSMD3, LRP2, TSC1, TRAK1, NFE2L3, PDZD2, ERBB3, TRRAP, PIK3R4, LAMA4, NCOR1, ERBB2, KALRN, ATM, CHD6, ANK2, KMT2C, FAT4 (n=37)
|
99
TCC
|
Nat genet
|
42.778
|
Cancer Genome Atlas Research Network[6]
|
2014
|
CCND3, RHOA, ZFP36L1, HRAS, BTG2, PAIP1, FOXA1, RHOB, CDKN2A, FOXQ1, TXNIP, KLF5,TSC1, NFE2L2༌ELF3༌RXRA༌FBXW7༌ERBB3༌STAG2༌FGFR3༌ERCC2, RB1, CDKN1A༌EP300༌PIK3CA༌KDM6A༌ARID1A༌MLL2༌TP53. (n=29)
|
131
UC
|
Nature
|
42.778
|
Yap[7]
|
2014
|
TP53, KDM6A, TSC1, ATM, UNC5C, BRCA2, ERCC2, FANCD2, FANCD2, PALB2, BRCA1. (n=11)
|
81
MIBC
|
Clin Cancer Res
|
8.911
|
Ross[8]
|
2014
|
ERBB2, TP53, RB1, MCL1, ARIDIA, CCND1, RICTOR, MYCL1, MLL2, EGFR, RUNX1, RAF1, PTEN, PTCH1, PIK3R1, PIK3CA, NF2, MSH2, MDM2, KRAS, JAK2, IRS2, IDH2, HRAS, FBXW7, EPHA3, CCNE1, CCND3, BAP1, AURKA, AKT2. AKT1.(n=32)
|
15
MPUC
|
Clin Cancer Res
|
8.911
|
Sfakianos[9]
|
2015
|
FGFR3, KMT2D, KDM6A, KMT2C, STAG2, CDKN2A, TP53, CDKN2B, CREBBP, TSC1, PIK3CA, ARID1A, CCND1, HRAS. (n=14)
|
83
UTUC
102
UCB
|
Eur Urol
|
17.947
|
Hedegaard[10]
|
2016
|
FGFR3, KIAA1109, SYNE2, AHNAK, DST, RNF213, BIRC6, DYNC1H1, AKAP9, NF1, NIPBL, MACF1, PIK3CA, PLEC, KDM6A, BPTF, DSP, VPS13D, SRRM2, HUWE1, RANBP2, CEP350, SPTBN1, LMO7, MAST4, GIGYF2, ERBB2, TP53, PBRM1, C10orf137, SMAD3, SEMA3F, SMG5, WDR70, MAP3K5, PSD4, NASP, XPOT, FAT1, MLL3, MLL, STAG2, MYCBP2, EP300, ATM, ARID1A, ASH1L, CREBBP, MLL2, WNK1, ERBB3, BRWD1, ELF3, INADL, RB1, RHOB, RBM10, RXRA ((n=58)
|
460
early-stage UC
|
Cancer Cell
|
26.602
|
Longo[11]
|
2016
|
FBXW7, PIK3CA, PIK3R1, PTEN, TSC1, BRAF, KRAS, NF1, ALK, EGFR, ERBB2, FGFR3, KMT2D, SETD2, SMARCB1, TET2, ATM, BRCA1, BRCA2, CDKN2A, JAK1, RB1, TP53. (n=23)
|
50
BC
|
Eur Urol
|
17.947
|
Pietzak[12]
|
2017
|
FGFR3, KRAS, HRAS, ERBB2, ERBB3, PIK3CA, TSC1, NF1, TP53, MDM2, RB1, CDKN2A, CDKN1A, CCND1, STAG2, KDM6A, KMT2D, ARID1A, KMT2A, KMT2C, EP300, CREBBP. (n=22)
|
105
NMIBC
|
Eur Urol
|
17.947
|
Roy[13]
|
2017
|
TP53, KRAS, TERT, PIK3CA, CTNNB1, APC, SMO, FEXW7, IDH2, PDGFRA, RB1. (n=11)
|
15
BA
|
Mod Pathol
|
5.988
|
Glaser[14]
|
2017
|
ARID1A, BRWD1, C3orf70, CCND1, CDKN1A, CDKN2A, CDKN2B, CHIT1, CREBBP, ELF3, EP300, ERBB2, ERBB3, ERBB4, ERCC2, FAM47C, FGFR3, HRAS, IRS4, KDM6A, KLF5, KMT2C, KMT2D, KRAS, MBD1, NFE2L2, PIK3CA, RB1, RHOA, RHOB, RXRA, STAG2, TGFBR1, TP53, TSC1, TXNIP, TYRO3, ZFP36L1. (n=38).
|
487
MIBC, NMIBC
|
Nat Rev Urol
|
11
|
Robertson[15]
|
2017
|
TP53, KMT2D, KDM6A, ARID1A, PIK3CA, KMT2C ,RB1, EP300, FGFR3, STAG2, ATM, FRT1, ELF3, CREBBP, ERBB2, SPTAN1, KMT2A, ERBB3, ERCC2, CDKN1A, ASXL2, TSC1, FBXW7.(n=23)
|
412
MIBC
|
Cell
|
38.637
|
Moss[16]
|
2017
|
FGFR3, KMT2, PIK3CA, TP53, KDM6A, CDKN2A/B, ATM, ZFHX4, ADY2, ARID1A, ERBB3, ERCC2, NPHS1, RHOB, SPTB, TSC1, CCND1, CREBBP, STAG2, SH3KBP1. (n=20)
|
31
UTUC
|
Eur Urol
|
17.947
|
Hurst[17]
|
2017
|
FGFR3, PIK3CA,KDM6A༌STAG2༌KMT2D༌ARID1A༌EP300༌KMT2C༌CREBBP༌RHOB༌HRAS༌KMT2A༌TSC1,BRCA2༌COL11A1༌RBM10, UNC80, CEP290,CLTC༌ MECOM༌UTY༌MAGI3༌DYNC1H1, KIF16B༌ RREB1, USP47, ZFYVE26. (n=27)
|
140
Ta NIBC
|
Cancer Cell
|
26.602
|
Nassar[18]
|
2018
|
FGFR3, KDM6A, TP53, RB1, HRAS.(n=5)
|
472
NMIBC, MIBC,UTUC
|
Clin Cancer Res
|
10.107
|
Shen[19]
|
2018
|
TP53, RB1, PRUNE2, NOTCH1, TMEM132D, EP300, CREBBP, MLL2, ARID1A, PIK3CA, MEN1, DAXX/ATRX, CTNNB1, KRAS, PTEN, ALK, CDKN2A, BRCA2, FGFR3, CDKN1B, TERT, SMAD4, MYCN. (n=24)
|
12 NEBC
|
Oncogene
|
7.971
|
Agarwal[20]
|
2018
|
TP53, PIK3CA, ARID1A, ERBB2, EGFR, FGFR3, TERT, NF1, EGFR2, BRCA1, BRCA2, BRAF, CCNE1, FGFR1, FGFR3, KIT, MET, RAF1, FGFR2, NOTCH1, APC, AR, KRAS, QNAS, HRAS, MYC, NTRK1, STK11, CDH1, FBXW7, ALK, CDK4, CDK5, CDKN2A,PDGFRA, TSC1, ATM, CCND1, MTOR, RB1, SMAD4, EZH2, HNF1A, JAK2, MAP2K1, MLH1, NFE2L2, NARS, PTEN, PTPN11, SMO, GATA3, MAP2K2, MAPK1, RET, RHOA, RIT1, ROS1. (n=58)
|
369 mUC
|
Cancer
|
5.742
|
Wu [21]
|
2019
|
FGFR3, TP53, PIK3CA, ZFP36L1, HRAS, KDM6A, ELF3, KRAS, STAG2,ERBB2. RB1.CASP8 ,CDKN1A, PMS2, CRIPAK, ERCC4, RBM15, ZNF814, TERT, ADGRG6, PLEKHS1, TBC1D12, WDR74, LEPROTL1, PLXDC1, CDKN2A, FHIT, TC28, LRP1B, MDM2, CCND1, FRS2, SHANK2, LRRC10, CDKAL1, PDE4D, FOCAD, CCT2, KCNB2, VPS13B, GPC5, ATP8A2, ELAVL2, RBFOX1, PTPRR,ITSN1, TPCN2, CCSER1. (n=46)
|
32
NMIBC
33
MIBC
|
Nat Commun
|
14.919
|
Pietzak[22]
|
2019
|
ERCC2, TP53, CDKN2A, RB1, KDM6A, ARID1A, KMT2D, PIK3CA, ERBB2, FGFR3, STAG2. (n=11)
|
245
primary MIBC secondary MIBC
|
Eur Urol
|
18.728
|
Isharwal[23]
|
2019
|
HRAS, KRAS, PTEN, EP300, KDM6A, HLA-A,STAG2, PIK3R1, BRAF, AKT1, TERT, FGFR3, KMT2D, PIK3CA, RBM10. (n=15)
|
22
11 IUP
11 UP
|
J Pathol
|
5.979
|
Majewski[24]
|
2019
|
POM121C, KMT2D, ATM, ELMOD2, CDH17, PRKCI, KRAS, PCDHGA2, HYDIN, FOXQ1, PCDHA7, UNC80, DZIP1L, FAM90A1, VPS13A, ACIN1, MED12, STOX1, RAD1, OR2G2, ADNP, TAF1. (n=22)
|
|
Cell Rep,
|
8.109
|
Lawson[25]
|
2020
|
KMT2D, KDM6A, ARID1A, RBM10, EP300, STAG2, CDKN1A, NOTCH2, CREBBP, FOXQ1.(n=10)
|
20
Bladder
|
Science
|
41.845
|
Bellmunt[26]
|
2020
|
TP53, KMT2D, KDM6A, KMT2C, CREBBP, RB1, ERBB3, ERCC2, EP300, RHOB, ERBB2, STAG2, PIK3CA, FGFR3, ASXL2, ARID1A, BRCA2. (n=17)
|
62
HGT1
|
Cancer Res
|
12.701
|
Necchi[27]
|
2020
|
TERT, TP53, CDKN2A, CDKN2B, KDM6A, ARID1A, MLL2, PIK3CA, RB1, FGFR3, ERBB2, CCND1, FGF19, FGF4, FGF3, MDM2, MLL3, TSC1, CREBBP, STAG2, FRS2, MCL1, EP300, RAF1, LRP1B, ZNF703, CCNE1, KRAS, ERBB3, RBM10, FBXW7, MYC, FGFR1, SMARCA4, HRAS. (n=36)
|
479
UTUC
1984
BC
|
Eur Urol Focus
|
4.827
|
Kim[28]
|
2020
|
FGFR3, KDM6A, KMT2D, TERT, TP53, STAG2, ARID1A, CREBBP, HRAS, PIK3CA, TSC1, ERBB2, KRAS, CDKN2A, ERCC2, PTEN, RB1. (n=17)
|
119
UTUC
|
Nat Commun
|
14.919
|
Pal[29]
|
2020
|
KDM6A, CDKN2B, FGF3, ARID1A, KMT2D, CCND1, FGF19, FGF4, PIK3CA, STAG2, EP300, TSC1, TP53, FRS2, MDM2, FAT1, CREBBP, EMSY, ARID2, ERBB2, FBXW7, FOXP1, LZTR1,MSH2, NCOR1, NF1, NOTCH3, PTEN, RAD50, SF3B1, APC, BAP1, BCORL1, CTCF, DNMT3A, FANCA, KMT2C, NOTCH1, ZNF217. (n=38)
|
46
39 UCB
7 UTUC
|
Cancer
|
5.742
|
Yang[30]
|
2021
|
KMT2D, TP53, KMT2C, BRD4, LRP1B, NCOR1, ZFHX4, CREBBP, FAT1, SPEN, BRCA2, FGFR3, GNAQ, IRS2, KDM6A, KDR, NF1, NOTCH1, PIK3CA, RB1, ERCC2, INPPL1, KMT2A, ZFHX3, BRCA2, KDM6A, KMT5A, MDC1, ROS1, SPEN, ANKRD11. (n=31)
|
118
45 UTUC,
73 UCB.
|
Oncologist
|
5.025
|
Su[31]
|
2021
|
FGFR3, KDM6A, KMT2D, KMT2C, ZFP36L1, ARID1A, STAG2, TP53, CRIPAK, GANAB. (n=10)
|
30 UTUC
15 MIBC
15NMIBC
|
Genome Biol
|
10.806
|
UC= Urothelial carcinoma ; TCC= Transitional cell carcinoma;UTUC= Upper tract urothelial carcinoma; BC= Bladder cancer; NMIBC= Non-muscle invasive bladder cancer; MIBC= Muscle invasive bladder cancer༛ MPUC= Micro papillary urothelial carcinoma; UCB= Urothelial carcinoma of the bladder༛pg HG=High grade༛BA= Bladder adenocarcinoma; mUC= Metastatic urothelial carcinoma; NEBC= Neuroendocrine bladder cancer.
|