This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Liang-Long Chen
Union Hospital, Fujian Medical University
Corresponding Author
License:
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Introduction
: No-reflow phenomenon (NRP) is one of high-incidence complication during percutaneous coronary intervention(PCI). In the current study, we examined the relationship between MELD-XI score and NRP in detail. Moreover, we further discuss whether MELD-XI score could consider as an accurate risk assessment score of patients with STEMI candidate for PCI.
Methods
This retrospective study involving 693 Patients with acute STEMI underwent an emergency PCI were consecutive recruited. All patients divided into normal reflow or no-reflow groups based in result of post interventional thrombolysisin myocardial in farction(TIMI) flow rate. Univariate and multivariate logistic regression and Cox regression analysis were conducted to identify the independent predictors of determine the independent predictive factor in both group. Receiver operator characteristic (ROC) curve and Kaplan-Meier (K-M) have been applied to estimate the predictive values of MELD-XI score.
Results
MELD-XI score is a independently indicator of NRP(odds ratio(OR):1.247, 95%CI:1.144-1.360, P<0.001). A multivariate Cox regression analysis also revealed that MELD-XI score is an independent prognostic factor for 30-days all-cause mortality(hazard ratio(HR):1.155, 95%CI:1.077-1.239, P<0.001). Moreover, the cutoff value of MELD-XI score to predict NRP was 9.47 by ROC curve, area under ROC curve(AUC):0.739, P<0.001. Kaplan-Meier curves for 30-days all cause mortality revealed lower survival rate in MELD-XI ༞9.78 group(P༜0.001).
Conclusion
The MELD-XI score predict NRP and 30-days prognosis accurately in STEMI patients whom undergoing PPCI. It could as an inexpensive and readily available tool for risk stratification.
Keywords
No-reflow phenomenon, MELD-XI, Short-term outcome, ST-segment elevation myocardial infarction, liver and renal dysfunction, Percutaneous coronary intervention
Figure 1
Figure 2
No competing interests reported.
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On 03 Nov, 2021
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This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Liang-Long Chen
Union Hospital, Fujian Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 28 Oct, 2021
No community comments so far
Editorial decision: Major revision
On 30 Nov, 2021
Reviews received
Received 28 Nov, 2021
Reviewers agreed
On 19 Nov, 2021
Reviewers agreed
On 03 Nov, 2021
Reviewers invited
Invitations sent on 02 Nov, 2021
Editor assigned
On 27 Oct, 2021
Editor invited
On 27 Oct, 2021
Submission checks complete
On 27 Oct, 2021
First submitted
On 22 Oct, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction
: No-reflow phenomenon (NRP) is one of high-incidence complication during percutaneous coronary intervention(PCI). In the current study, we examined the relationship between MELD-XI score and NRP in detail. Moreover, we further discuss whether MELD-XI score could consider as an accurate risk assessment score of patients with STEMI candidate for PCI.
Methods
This retrospective study involving 693 Patients with acute STEMI underwent an emergency PCI were consecutive recruited. All patients divided into normal reflow or no-reflow groups based in result of post interventional thrombolysisin myocardial in farction(TIMI) flow rate. Univariate and multivariate logistic regression and Cox regression analysis were conducted to identify the independent predictors of determine the independent predictive factor in both group. Receiver operator characteristic (ROC) curve and Kaplan-Meier (K-M) have been applied to estimate the predictive values of MELD-XI score.
Results
MELD-XI score is a independently indicator of NRP(odds ratio(OR):1.247, 95%CI:1.144-1.360, P<0.001). A multivariate Cox regression analysis also revealed that MELD-XI score is an independent prognostic factor for 30-days all-cause mortality(hazard ratio(HR):1.155, 95%CI:1.077-1.239, P<0.001). Moreover, the cutoff value of MELD-XI score to predict NRP was 9.47 by ROC curve, area under ROC curve(AUC):0.739, P<0.001. Kaplan-Meier curves for 30-days all cause mortality revealed lower survival rate in MELD-XI ༞9.78 group(P༜0.001).
Conclusion
The MELD-XI score predict NRP and 30-days prognosis accurately in STEMI patients whom undergoing PPCI. It could as an inexpensive and readily available tool for risk stratification.
Figure 1
Figure 2
No competing interests reported.
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