Explosion is the act of generating huge energy in an instant and spreading rapidly around it. Due to the suddenness, fast propagation speed and high peak load of explosions, compared with other natural disasters, the damage it brings to humans is more significant and difficult to prevent. Among them, the explosion of acetylene-air mixture is the most typical explosion problem. This paper uses SAP2000 finite element software to perform a fine simulation of actual explosion events, studies the effect of the explosion of acetylene-air mixture on the frame structure column, and discusses the displacement and acceleration changes of various components. Research shows that the use of the principle of linear assumption of explosive load can effectively simulate the actual explosion situation. The structural damage and deformation caused by the explosive load have locality and weak transmission. When the peak of the explosion load is larger, the structure deformation is greater, and the impact of the explosion load on the structure is isotropic.