Article ID
|
Tangle count
|
Braak score
|
Plaque count
|
CERAD
|
Thal Phase
|
Clinical diagnosis
|
Primary neuropathological diagnosis
|
Neuropathological co-pathologies
|
1
|
15
|
V
|
15
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
Microscopic changes of Lewy body disease, AGD, infarcts, TDP-43 proteinopathy
|
2
|
3.5
|
III
|
0
|
zero
|
Missing/unknown
|
Parkinson's disease
|
Parkinson's disease
|
Definite PART, AGD
|
3
|
7.5
|
IV
|
15
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
White matter changes, hemorrhage, infarcts, TDP-43 proteinopathy
|
4
|
7.5
|
IV
|
0
|
zero
|
Phase 0 (A0)
|
Vascular parkinsonism
|
Vascular dementia
|
Definite PART
|
5
|
2.5
|
II
|
0
|
zero
|
Phase 0 (A0)
|
Multiple sclerosis
|
Multiple sclerosis
|
Definite PART
|
6
|
3.5
|
III
|
9
|
moderate
|
Phase 2 (A1)
|
Parkinson's disease
|
AD
|
Parkinson's disease, infarcts
|
7
|
6.5
|
IV
|
0
|
zero
|
Phase 0 (A0)
|
Control
|
Definite PART
|
NA
|
8
|
5
|
IV
|
0
|
zero
|
Phase 0 (A0)
|
Parkinson's disease
|
Parkinson's disease
|
Definite PART, AGD, ARTAG
|
9
|
3.5
|
II
|
7.5
|
sparse
|
Phase 2 (A1)
|
Parkinson's disease
|
Parkinson's disease
|
Possible PART
|
10
|
7
|
IV
|
14
|
frequent
|
Missing/unknown
|
Control
|
AD pathology, but insufficient for diagnosis
|
Infarcts
|
11
|
7.5
|
IV
|
14
|
frequent
|
Phase 3 (A2)
|
Dementia NOS
|
AD
|
Astrocytoma, cerebral amyloid angiopathy, incidental Lewy body disease, infarcts, radiation changes
|
12
|
5
|
III
|
0
|
sparse
|
Phase 0 (A0)
|
Parkinson's disease
|
Parkinson's disease
|
Possible PART, AGD, ARTAG
|
13
|
7
|
IV
|
8.5
|
frequent
|
Phase 2 (A1)
|
Alzheimer's disease
|
AD
|
AGD, ARTAG
|
14
|
15
|
V
|
15
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
Infarcts, Microscopic changes of Lewy body disease
|
15
|
4
|
III
|
0
|
zero
|
Phase 0 (A0)
|
Control
|
Definite PART
|
Cerebral amyloid angiopathy, incidental Lewy body disease
|
16
|
3
|
II
|
0
|
zero
|
Phase 0 (A0)
|
Parkinsonism
|
White matter changes
|
Definite PART, infarcts
|
17
|
0
|
I
|
0.5
|
zero
|
Phase 1 (A1)
|
Amyotrophic lateral sclerosis
|
Amyotrophic lateral sclerosis
|
Definite PART
|
18
|
14
|
V
|
14
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
White matter changes, Alzheimer type II astrocytosis, microscopic changes of Lewy body disease
|
19
|
6.75
|
IV
|
12.5
|
frequent
|
Missing/unknown
|
Control
|
AD pathology, but insufficient for diagnosis
|
White matter changes, infarcts, AGD
|
20
|
6.5
|
III
|
0
|
zero
|
Phase 0 (A0)
|
Control
|
Definite PART
|
White matter changes, cerebral amyloid angiopathy
|
21
|
6.5
|
III
|
0
|
zero
|
Phase 0 (A0)
|
Parkinson's disease
|
Parkinson's disease
|
Definite PART, infarcts
|
22
|
7
|
IV
|
13.5
|
frequent
|
Missing/unknown
|
Mild Cognitive Impairment
|
AD pathology, but insufficient for diagnosis
|
White matter changes
|
23
|
3
|
III
|
0
|
zero
|
Phase 0 (A0)
|
Parkinson's disease
|
Parkinson's disease
|
Definite PART, cerebral amyloid angiopathy
|
24
|
7.5
|
IV
|
13.5
|
frequent
|
Missing/unknown
|
Alzheimer's disease
|
AD
|
Etat crible, white matter changes, focal marked unilateral loss of cervical spinal cord anterior horn motor neurons
|
25
|
4.5
|
IV
|
0
|
zero
|
Missing/unknown
|
Parkinsonism
|
Definite PART
|
AGD, infarct
|
26
|
11.5
|
VI
|
14.5
|
frequent
|
Phase 4 (A3)
|
Mixed vascular dementia
|
AD
|
Dementia with Lewy bodies, white matter changes, infarcts, ARTAG
|
27
|
7
|
IV
|
0.5
|
sparse
|
Phase 1 (A1)
|
Parkinson's disease
|
Parkinson's disease
|
Possible PART, white matter changes
|
28
|
3.5
|
III
|
0
|
zero
|
Phase 0 (A0)
|
Frontotemporal Dementia
|
FTLD with TDP-43 proteinopathy
|
Definite PART, microscopic changes of Lewy body disease
|
29
|
5
|
III
|
9
|
frequent
|
Phase 3 (A2)
|
Alzheimer's disease
|
AD
|
NA
|
30
|
9
|
IV
|
14
|
frequent
|
Phase 5 (A3)
|
Mild Cognitive Impairment
|
AD
|
White matter changes
|
31
|
10.5
|
V
|
14.5
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
AGD, ARTAG, microscopic changes of Lewy body disease
|
32
|
9.5
|
V
|
14.5
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
White matter changes, moderate to marked Purkinje cell loss, ARTAG
|
33
|
9.5
|
V
|
13.5
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
Hippocampal sclerosis, TDP-43 proteinopathy, white matter changes, microscopic changes of Lewy body disease
|
34
|
7.5
|
IV
|
1
|
sparse
|
Phase 1 (A1)
|
Parkinson's disease
|
Parkinson's disease
|
Possible PART, ARTAG, AGD
|
35
|
8
|
IV
|
0
|
zero
|
Phase 0 (A0)
|
Mild Cognitive Impairment
|
None
|
Definite PART, incidental Lewy body disease
|
36
|
8
|
IV
|
4.5
|
zero
|
Phase 2 (A1)
|
Mild Cognitive Impairment
|
None
|
Definite PART, AGD, ARTAG
|
37
|
8.5
|
IV
|
13
|
frequent
|
Phase 4 (A3)
|
Mild Cognitive Impairment
|
AD
|
Infarcts, white matter changes
|
38
|
15
|
V
|
14.5
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
Severe amyloid angiopathy, white matter changes, microscopic changes of Lewy body disease
|
39
|
11
|
V
|
14.5
|
frequent
|
Phase 5 (A3)
|
Mixed vascular dementia
|
AD
|
Severe amyloid angiopathy, white matter changes, hemorrhages, infarcts, cerebellar cortical sclerosis, microscopic changes of Lewy body disease
|
40
|
10
|
V
|
15
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
Microscopic changes of Lewy body disease, meningioma
|
41
|
6.5
|
IV
|
15
|
frequent
|
Phase 3 (A2)
|
Parkinson's disease
|
AD
|
Parkinson's disease, white matter changes, infarct
|
42
|
8.5
|
IV
|
13
|
frequent
|
Phase 3 (A2)
|
Progressive supranuclear palsy
|
AD
|
Progressive supranuclear palsy, white matter changes, infarcts, AGD, ARTAG, microscopic changes of Lewy body disease
|
43
|
7
|
IV
|
14.5
|
frequent
|
Phase 5 (A3)
|
Mixed vascular dementia
|
AD
|
White matter changes, infarcts, Wallerian degeneration, left cerebral peduncle of midbrain, AGD
|
44
|
6
|
IV
|
0
|
zero
|
Phase 0 (A0)
|
Control
|
Definite PART
|
AGD, ARTAG
|
45
|
7.5
|
IV
|
3
|
sparse
|
Phase 1 (A1)
|
Control
|
Possible PART
|
AGD
|
46
|
7
|
V
|
13
|
frequent
|
Phase 4 (A3)
|
Alzheimer's Disease & Vascular dementia
|
AD
|
White matter changes, infarcts, ARTAG
|
47
|
12.5
|
VI
|
14.5
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
Progressive supranuclear palsy, infarcts, ARTAG
|
48
|
6.5
|
III
|
0
|
zero
|
Phase 0 (A0)
|
Parkinson's disease
|
Parkinson's disease
|
Definite PART, ARTAG
|
49
|
3.5
|
III
|
14
|
frequent
|
Phase 4 (A3)
|
Control
|
AD pathology, but insufficient for diagnosis
|
NA
|
50
|
5
|
III
|
0.5
|
sparse
|
Phase 1 (A1)
|
vascular cognitive impairment
|
White matter changes
|
Possible PART, infarcts
|
51
|
6.5
|
IV
|
0
|
zero
|
Phase 0 (A0)
|
vascular cognitive impairment
|
White matter changes
|
Definite PART, infarcts, AGD, ARTAG
|
52
|
4
|
III
|
0
|
zero
|
Phase 0 (A0)
|
Parkinson's disease
|
Parkinson's disease
|
Definite PART, ARTAG
|
53
|
6.5
|
III
|
0
|
zero
|
Phase 0 (A0)
|
Control
|
Definite PART
|
Acute infarct
|
54
|
6.5
|
IV
|
0.5
|
sparse
|
Phase 1 (A1)
|
Control
|
Possible PART
|
ARTAG
|
55
|
6
|
III
|
13.5
|
frequent
|
Phase 3 (A2)
|
Control
|
AD pathology, but insufficient for diagnosis
|
Purkinje cell loss, cerebellum
|
56
|
7
|
IV
|
0
|
zero
|
Phase 0 (A0)
|
Mild Cognitive Impairment
|
Definite PART
|
White matter changes, ARTAG, AGD
|
57
|
4.5
|
III
|
4
|
frequent
|
Missing/unknown
|
Parkinson's disease
|
Parkinson's disease
|
White matter changes, infarcts, ARTAG
|
58
|
3.5
|
III
|
0
|
sparse
|
Phase 1 (A1)
|
Parkinson's disease
|
Parkinson's disease
|
Possible PART, ARTAG, infarcts
|
59
|
3.5
|
III
|
1
|
sparse
|
Phase 1 (A1)
|
Primary lateral sclerosis
|
Possible PART
|
White matter changes
|
60
|
5.5
|
III
|
0
|
zero
|
Phase 0 (A0)
|
Parkinson's disease
|
Parkinson's disease
|
Definite PART, white matter changes, infarcts, ARTAG
|
61
|
4.5
|
III
|
11.5
|
frequent
|
Phase 3 (A2)
|
Mild Cognitive Impairment
|
Glioblastoma
|
AD pathology, but insufficient for diagnosis, White matter changes, AGD, ARTAG, infarcts
|
62
|
4.5
|
III
|
4.5
|
sparse
|
Phase 3 (A2)
|
Control
|
None
|
Possible PART, incidental Lewy body disease
|
63
|
4.5
|
III
|
2
|
sparse
|
Phase 1 (A1)
|
Control
|
None
|
Possible PART, ARTAG
|
64
|
7
|
IV
|
12
|
frequent
|
Phase 3 (A2)
|
Alzheimer's disease
|
AD
|
AGD, ARTAG, severe loss of Purkinje cells, superior vermis of cerebellum
|
65
|
7.5
|
IV
|
0
|
zero
|
Phase 0 (A0)
|
Control
|
None
|
Definite PART, ARTAG, incidental Lewy body disease, white matter changes
|
66
|
5.5
|
III
|
2
|
sparse
|
Phase 2 (A1)
|
Control
|
None
|
Possible PART, ARTAG, microscopic changes of Lewy body disease
|
67
|
5
|
IV
|
10.5
|
frequent
|
Phase 3 (A2)
|
Parkinson's disease
|
NA
|
NA
|
68
|
6
|
IV
|
0
|
zero
|
Phase 0 (A0)
|
Control
|
None
|
Definite PART, white matter changes
|
69
|
4.5
|
III
|
14.5
|
frequent
|
Phase 4 (A3)
|
Mild Cognitive Impairment
|
AD pathology, but insufficient for diagnosis
|
Infarcts
|
70
|
3
|
III
|
0
|
zero
|
Phase 0 (A0)
|
Dementia NOS
|
Neurofibrillary tangle-predominant dementia
|
Definite PART, infarcts
|
71
|
5.5
|
IV
|
2.5
|
sparse
|
Phase 1 (A1)
|
Parkinson's disease
|
Parkinson's disease
|
Possible PART, AGD, ARTAG, white matter changes
|
72
|
10.5
|
V
|
14
|
frequent
|
Phase 4 (A3)
|
Alzheimer's Disease & DLB
|
AD
|
Dementia with Lewy bodies, ARTAG
|
73
|
6.5
|
IV
|
11
|
frequent
|
Phase 3 (A2)
|
Multiple system atrophy
|
AD
|
Multiple system atrophy, white matter changes, AGD
|
74
|
8
|
IV
|
9.5
|
frequent
|
Phase 3 (A2)
|
Mild Cognitive Impairment
|
AD
|
White matter changes, infarct, ARTAG
|
75
|
8
|
IV
|
10
|
frequent
|
Phase 3 (A2)
|
Parkinsonism
|
AD
|
Dementia with Lewy bodies, AGD, ARTAG
|
76
|
9.5
|
V
|
14.5
|
frequent
|
Phase 4 (A3)
|
Alzheimer's disease
|
AD
|
NA
|
77
|
6
|
IV
|
12
|
frequent
|
Phase 3 (A2)
|
Mild Cognitive Impairment
|
AD pathology, but insufficient for diagnosis
|
NA
|
78
|
6
|
III
|
14
|
frequent
|
Phase 3 (A2)
|
Control
|
AD pathology, but insufficient for diagnosis
|
Infarcts, Purkinje cell loss, cerebellum
|
79
|
15
|
V
|
14
|
frequent
|
Phase 4 (A3)
|
Alzheimer's disease
|
AD
|
Severe amyloid angiopathy, white matter changes, infarcts, microscopic changes of Lewy body disease
|
80
|
5.5
|
IV
|
0
|
zero
|
Phase 0 (A0)
|
Control
|
Definite PART
|
Astrocytoma diffuse (grade II), AGD, white matter changes
|
81
|
11.5
|
VI
|
15
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
Severe amyloid angiopathy, hemorrhage, AGD
|
82
|
13.5
|
VI
|
14
|
frequent
|
Phase 5 (A3)
|
Alzheimer's disease
|
AD
|
White matter changes, microscopic changes of Lewy body disease, TDP-43 proteinopathy
|
83
|
5
|
III
|
13.5
|
frequent
|
Phase 2 (A1)
|
Control
|
AD
|
White matter changes, infarcts
|
84
|
5.5
|
IV
|
13
|
frequent
|
Phase 4 (A3)
|
Control
|
AD pathology, but insufficient for diagnosis
|
Incidental Lewy Body disease, metastatic adenocarcinoma, infarct, ARTAG
|
85
|
8.5
|
IV
|
12.5
|
frequent
|
Phase 3 (A2)
|
Mixed vascular dementia
|
AD
|
TDP-43 proteinopathy, progressive supranuclear palsy, white matter changes
|
86
|
6.5
|
IV
|
3
|
sparse
|
Phase 2 (A1)
|
Control
|
Possible PART
|
TDP-43 proteinopathy
|
87
|
3
|
III
|
9.5
|
frequent
|
Phase 3 (A2)
|
Mixed vascular dementia
|
AD
|
White matter changes, infarcts
|
88
|
5
|
III
|
8
|
frequent
|
Phase 3 (A2)
|
Parkinson's disease
|
AD
|
Parkinson's disease, infarct
|