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Research article
Zhangzhe Peng
Corresponding Author
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Background: Thymoma is often associated with a series of paraneoplastic syndromes. Among them, thymoma-related nephrotic syndrome is much rare.
Methods: This retrospective study collected data from patients with thymoma and renal involvement in Xiangya Hospital, Central South University in a period of 5 years to investigate the clinical characteristics of thymoma-associated nephrotic syndrome.
Results: Seven patients were studied (age: 51.1±21.4 years old; male/female ratio: 5/2). Among them, thymic pathology revealed 2 cases of type A and 1 case of type B3, myasthenia gravis (MG) was found in 1 out of 7 cases. Renal pathology showed 2 cases of FSGS and 1 case of IgA nephropathy. 2 out of 7 cases who received combined therapy of steroid and immunosuppressive drugs achieved complete remission. Despite 3 out of 7 cases received surgical excision of thymoma, 2 of them experienced treatment failure in nephrotic syndrome.
Conclusions: nephrotic syndrome can be associated with thymoma. The FSGS is the most frequent thymoma-associated glomerular lesion in this study. IgA nephropathy may be another pathological type in thymoma-associated NS. Despite after surgical excision, long treatment periods with high dosage of steroid combined with immunosuppressants were needed to achieve complete remission.
Keywords
Thymoma, nephrotic syndrome
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This is a preprint. It has not completed peer review.
Research article
Zhangzhe Peng
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 23 Dec, 2019
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Urology & Nephrology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Thymoma is often associated with a series of paraneoplastic syndromes. Among them, thymoma-related nephrotic syndrome is much rare.
Methods: This retrospective study collected data from patients with thymoma and renal involvement in Xiangya Hospital, Central South University in a period of 5 years to investigate the clinical characteristics of thymoma-associated nephrotic syndrome.
Results: Seven patients were studied (age: 51.1±21.4 years old; male/female ratio: 5/2). Among them, thymic pathology revealed 2 cases of type A and 1 case of type B3, myasthenia gravis (MG) was found in 1 out of 7 cases. Renal pathology showed 2 cases of FSGS and 1 case of IgA nephropathy. 2 out of 7 cases who received combined therapy of steroid and immunosuppressive drugs achieved complete remission. Despite 3 out of 7 cases received surgical excision of thymoma, 2 of them experienced treatment failure in nephrotic syndrome.
Conclusions: nephrotic syndrome can be associated with thymoma. The FSGS is the most frequent thymoma-associated glomerular lesion in this study. IgA nephropathy may be another pathological type in thymoma-associated NS. Despite after surgical excision, long treatment periods with high dosage of steroid combined with immunosuppressants were needed to achieve complete remission.
Figure 1
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