Collagen-based dressings achieve excellent repair of the skin during metical cosmetology, which has received a lot of attention recently. Although great progress has been made on using biomass fiber as dressing carrier, more research is required on developing novel biomass fibers because of the limitations of (i.e., high cost and complex processing) of existing materials. In this study, the adsorption behaviors of two human-like collagen were studied by examining the Kapok fiber that was modified using alkali consisting of various amounts of the mass fraction. Results show that the alkali-modified Kapok fiber surface becomes rough with vertically arranged grooves, and the cross-section depicts the hollow cavity structure. The composition analysis of alkali modified Kapok shows that alkali dissolves part of the hemicellulose and lignin. Additionally, the surface energy rises sharply and the water contact angle changed from hydrophobic to hydrophilic. The adsorption amount of raw Kapok fiber is around 0.6g/g, which accounts for only one twenty-first of the adsorption amount of alkali-treated Kapok (around 12.6g/g), while the equilibrium adsorption amount was not sensitive to alkali concentration. The kinetics of human-like collagen followed both Quasi first and Quasi second order kinetic model, implying that the adsorption process where characterized by both physisorption and chemisorption. Finally, characterization of the AKF-2 coupled with the studies based on the inter-particle diffusion model showed a three-step of human-like collagen diffusion consisting of surface diffusion, inter-fiber diffusion and fiber' hollow cavity diffusion. Our results demonstrate a perfect high absorption performance of Kapok fiber providing a potential for application of collagen-base dressings.