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Research article
Wenming Zhang
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1567-7279
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This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
The purpose of this study was to compare the clinical outcomes of culture-negative periprosthetic infection (CN PJI) with those of culture-positive periprosthetic infection (CP PJI).
Methods
The clinical data of 77 patients with prosthetic infections were collected retrospectively. The mean follow-up time was 29.2 months (12-76 months). The remission rates of CN PJI and CP PJI were compared. The effects of the culture results on the curative effect were further compared by survival analysis. The correlations between sex, age, underlying diseases, sinus, disease course, joint involvement, surgical strategy, culture results and clinical outcomes were further analyzed by logistic regression.
Results
In total, there were 24 cases of CN PJI, with an incidence of 29.63%. The overall success rate of CN PJI was 86.4% (19/22),and overall success rate of CP PJI was 87.5% (42/48). There was no significant difference in the success rate between CN PJI and CP PJI. The incidence of antibiotic-related complications for CN PJI was significant higher than that for CP PJI, with 58.3% for CN PJI and 11.3% for CP PJI, respectively.
Conclusion
CN PJI was treated according to the strict standards for the diagnosis and treatment, and the success rate of treatment for CN PJI was similar to that for CP PJI. The incidence of antibiotic-related complications from CN PJI was higher than that from CP PJI.
Keywords
Periprosthetic joint infection, culture negative, success rate, antibiotics, complications
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Wenming Zhang
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1567-7279
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 26 Dec, 2019
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
The purpose of this study was to compare the clinical outcomes of culture-negative periprosthetic infection (CN PJI) with those of culture-positive periprosthetic infection (CP PJI).
Methods
The clinical data of 77 patients with prosthetic infections were collected retrospectively. The mean follow-up time was 29.2 months (12-76 months). The remission rates of CN PJI and CP PJI were compared. The effects of the culture results on the curative effect were further compared by survival analysis. The correlations between sex, age, underlying diseases, sinus, disease course, joint involvement, surgical strategy, culture results and clinical outcomes were further analyzed by logistic regression.
Results
In total, there were 24 cases of CN PJI, with an incidence of 29.63%. The overall success rate of CN PJI was 86.4% (19/22),and overall success rate of CP PJI was 87.5% (42/48). There was no significant difference in the success rate between CN PJI and CP PJI. The incidence of antibiotic-related complications for CN PJI was significant higher than that for CP PJI, with 58.3% for CN PJI and 11.3% for CP PJI, respectively.
Conclusion
CN PJI was treated according to the strict standards for the diagnosis and treatment, and the success rate of treatment for CN PJI was similar to that for CP PJI. The incidence of antibiotic-related complications from CN PJI was higher than that from CP PJI.
Figure 1
Figure 2
Figure 3
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