Purpose: Surgical stimulation causes many pathophysiological changes which are not conducive to the recovery of patients, this trail aims to investigate whether intercostal nerve block can reduce the perioperative stress response and postoperative pain in patients undergoing elective retroperitoneal laparoscopic nephrectomy.
Patients and methods:40 patients were recruited and randomly assigned to Test groupand Blank group.
Results: Our study found that the catecholamine and cortisol levels in two groups were higher than the baseline value after pneumoperitoneum, (P＜0.05), while the catecholamine level was lower in Test groupthan in Blank group (P＜0.05), and there is no differences of cortisol levels was observed in two groups. The catecholamines and cortisol levels of two groups were basically restored to the preoperative level after 24 hours surgery, The concentration of IL-6 and IL-10 in two groups increased at 24 hours after surgery, but there was no differences was observed between the two groups at the same point. And the usage of analgesic during operation was less in the Test group than Blank group (P＜0.05).
Conclusion : Intercostal nerve block can reduce the stress response of patients undergoing retroperitoneal laparoscopic nephrectomy and reduce the usage of perioperative analgesics.
Tial registration statement : This trial has been applied by the ethics Association of Chongqing cancer hospital.