Squamous cell carcinoma of the kidney in an End Stage Renal disease patient in a tertiary health care center; a case report and review of literature, Assiut university hospital experience 2021,

DOI: https://doi.org/10.21203/rs.3.rs-1024870/v1


The literature mentioned few case that are squamous cell carcinoma of the renal pelvis since 1955. Renal cell carcinoma with all its variants represent more than ninety percent, the remaining ten percent is divided on urothelial tumors, sarcomas and metastasis from other organs. Squamous cell carcinoma of the urothelium is not common, but in Egypt it was very frequently seen in the bladder, multiple cause are proposed such as the chronic irritation caused by Schistosomiasis infection .The general role of this type is that it is resistant to both chemo and radiotherapy with fair outcome to surgery if early intervention was done. This article will discuss a case that developed squamous cell carcinoma in the renal bed after nephrectomy, which was managed with excellent outcome in assiut university hospital

Case Report

A male patient 47 years old ESRD on regular dialysis for eleven years , no other comorbidity were found beside history of a lower urinary tract surgery either in the bladder or ureter 17 years ago and a left sub-capsular nephrectomy 2019 at our department because he was complaining of persistent pyuria  per urethera . After two years he presented with left loin pain and swelling that kept increasing in size and then eventually a skin sinus developed. MRI was done and showed a large lobulated mass at site of renal bed infiltrating the psoas muscle and lateral wall muscle measuring 14.5*7.5 cm with restricted diffusion. After reviewing his old biopsy it showed squamous metaplasia of the pelvicalyceal system and chronic glomerulonephritis. Ct guided biopsy revealed areas of hyperplastic squamous epithelium, strips of chronic inflammatory cellular infiltrate & the cells showed prominent nucleoli with occasional mitosis and extensive keratinization. His labs were within normal serum creatinine was five, hemoglobin was ten. Urgent salvage surgery was performed. A chevron incision was done, adhesiolysis and dissection of massive peritoneal and colonic adhesion until the retroperitoneal space is reached. A fungating mass is found infiltrating most of the posterior abdominal wall muscles and the rib, it was found to infiltrate part of omentum. Excision of the mass and most of the necrotic tissue, closure was done in layers despite the difficulty we faced due to the extensive loss in tissue architecture resulting from extensive infiltration of the tumor. The patient had a smooth postoperative recovery and drain was removed after five days, the wound showed some discharge which was trivial. He was discharged after 9 days. He was presented in the follow up after three month with satisfactory performance and a good wound healing. His biopsy showed moderately differentiated squamous cell carcinoma.


The most common variant of renal cell carcinoma in ESRD patients is papillary renal cell carcinoma .(1,2)  Squamous cell carcinoma of the renal pelvis is a very rare variant, its incidence range from less than 1 percent to less than 5-10 percent of all the upper urothelial tract tumors. (3,4) Squamous cell carcinoma in ESRD is mentioned in the literature very few, There is no definite cause to blame, but smoking, recurrent operation as PCNL, chronic irritation caused by stones or infection and squamous metaplasia are risk factors. (5–7)  The most common cause is stones leading to squamous metaplasia, which was found   in the previous kidney specimen that was removed from the patient two years ago. Squamous metaplasia considered by some authors as precancerous lesion, occurs more in the lower tract unlike the upper tract, and requires strict follow up(5,8) The clinical presentation of the disease includes no characteristic symptoms and signs, making it very difficult to diagnose as in this case the diagnosis was difficult, all the signs were making the diagnosis directed toward infection or retro-peritoneal abscess also the CT guided biopsy was not conclusive, until exploration was done.(9) Pain, hematuria, local swelling of the loin and  a fistula formation or skin sinus as in our patient are symptoms that may occur in advanced disease (5,7,10) . The treatment is radical surgery, due to the rarity of the cases the conclusive decision of applying radiotherapy or chemotherapy either in advanced or early cases, preoperatively or postoperatively, can’t be taken. (10–12)  To achieve similar outcome as transitional cell carcinoma the diagnosis must be early, as the main problem with this variant is its delayed diagnosis either according to the clinical picture or radiological(13).

Conclusion And Recommendation

Squamous cell carcinoma of renal pelvis is rare and highly aggressive. It has a high recurrence rate and low mean survival rate. Best treated by surgery. Our case is on regular dialysis that developed the recurrent tumor after nephrectomy for another cause. Stones, infection should be managed as early as possible with prevention of their recurrence. Nephrectomy in case of complicated renal disease should be radical. Regular follow up cystoscopy is required.


Yes the patient was approving

Taken from the patient and family


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