Research Article
Synthesis and Evaluation of Cyclic Diamino Benzamide Based D3 Receptor Ligands
https://doi.org/10.21203/rs.3.rs-1025538/v1
This work is licensed under a CC BY 4.0 License
published 02 Feb, 2022
Read the published version in Medicinal Chemistry Research →
You are reading this latest preprint version
Dopamine (1) is a key neurotransmitter whose impact on pharmacological processes is mediated by a family of dopamine receptors designated D1, D2, D3, D4, and D5. Various diseases and conditions such as schizophrenia, drug abuse, depression, restless leg syndrome, Parkinson’s disease (PD), and inflammatory diseases have been linked to aberrant D3 activity. Herein, we report a series of novel D3 ligands with improved solubility over our previous lead compound, MC25-41 (2).
published 02 Feb, 2022
Read the published version in Medicinal Chemistry Research →
Editorial decision: Major Revision
25 Nov, 2021
Reviews received at journal
10 Nov, 2021
Reviewers invited by journal
10 Nov, 2021
Editor assigned by journal
29 Oct, 2021
First submitted to journal
27 Oct, 2021
You are reading this latest preprint version