This preprint is under consideration at International Ophthalmology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Francisco Avila
Universidad de Zaragoza
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9068-7728
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: The aim of this work is to determinate the effects in the physical parameters in terms of intraocular pressure (IOP) and central corneal thickness (CCT) and corneal biomechanics in terms of corneal resistance factor (CRF) and corneal hysteresis (CH) of wearing silicone-hydrogel soft contact lenses (SiH-CLs) in young adult subjects during a short-term follow-up.
Methods: 40 eyes of 20 healthy patients with a mean age of 22.87±4.14 were involved in this study. Subjects with corneal diseases, dry eye, irregular astigmatism or who have been previous contact lens wearers were excluded. The Ocular Response Analyzer (Reichert Ophthalmic Instruments) was used to measure CH, CRF and IOP and Scheimpflug imaging (Galilei Dual Scheimpflug camera analyzer, Pentacam) was used to measure CCT before and 10 days (Group 1) and 20 days (Group 2) after using the SiH-CLs.
Results: IOP was decreased significantly 10 days after using the SiH-CLs (p=0.009). Within the 20 days' period, Group 2 revealed an even more pronounced decrease in IOP (p=.003) and CH increased significantly (p=.04). CCT and CRF did not show a significant change during the period of SiH-CLs use. Our finding allowed obtaining an analytical expression that relates IOP, CCT, CRF and CH within a biomechanical compensation experimental model.
Conclusions: Corneal biomechanical parameters and physical properties of the cornea may alter with SiH-CLs use. Our finding could have an impact on the management of glaucoma progression and ocular hypertension.
Keywords
Corneal biomechanics, soft contact lenses, intraocular pressure, glaucoma.
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CURRENT STATUS: Under Review
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Posted 08 Nov, 2021
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Received 08 Nov, 2021
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This preprint is under consideration at International Ophthalmology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Francisco Avila
Universidad de Zaragoza
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9068-7728
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 08 Nov, 2021
No community comments so far
Reviews received
Received 08 Nov, 2021
Reviewers invited
Invitations sent on 05 Nov, 2021
Editor assigned
On 02 Nov, 2021
First submitted
On 27 Oct, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: The aim of this work is to determinate the effects in the physical parameters in terms of intraocular pressure (IOP) and central corneal thickness (CCT) and corneal biomechanics in terms of corneal resistance factor (CRF) and corneal hysteresis (CH) of wearing silicone-hydrogel soft contact lenses (SiH-CLs) in young adult subjects during a short-term follow-up.
Methods: 40 eyes of 20 healthy patients with a mean age of 22.87±4.14 were involved in this study. Subjects with corneal diseases, dry eye, irregular astigmatism or who have been previous contact lens wearers were excluded. The Ocular Response Analyzer (Reichert Ophthalmic Instruments) was used to measure CH, CRF and IOP and Scheimpflug imaging (Galilei Dual Scheimpflug camera analyzer, Pentacam) was used to measure CCT before and 10 days (Group 1) and 20 days (Group 2) after using the SiH-CLs.
Results: IOP was decreased significantly 10 days after using the SiH-CLs (p=0.009). Within the 20 days' period, Group 2 revealed an even more pronounced decrease in IOP (p=.003) and CH increased significantly (p=.04). CCT and CRF did not show a significant change during the period of SiH-CLs use. Our finding allowed obtaining an analytical expression that relates IOP, CCT, CRF and CH within a biomechanical compensation experimental model.
Conclusions: Corneal biomechanical parameters and physical properties of the cornea may alter with SiH-CLs use. Our finding could have an impact on the management of glaucoma progression and ocular hypertension.
Figure 1
Figure 2
Figure 3
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