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Research Article
hossein danafar
Zanjan University of Medical Sciences
Corresponding Author
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In this work, first, copper oxide nanoparticles (CUO NPs) were synthesized by physical methods and then coated with the bovine serum albumin (BSA) via biologically meditated minerals to form [email protected] NPs. Finally, curcumin (CUR) as an anticancer drug were immobilized on the surface of [email protected] NPS. The properties of [email protected] NPS were investigated by FTIR, UV-Vis, TEM, and AFM spectroscopes. It was found that the synthesized [email protected] nanoparticles were spherical with a particle size of 20 to 30 nm and have a sustained release of CUR at 37°C in buffer solution. Also, the result of release in biological environment showed that maximum drug release rate for this nanocarrier in pH 7.4 was measured 75% after 48 hours. The cytotoxicity of [email protected] on MDA-MB-231 cell line was studied. The results showed that [email protected] nanoparticles have significant cytotoxic activity on this cell line, while the results of MTT assay indicated the [email protected] NPs have no toxicity effect on the cancer cells.
Keywords
Copper oxide, Bovine serum albumin, Curcumin
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This preprint is under consideration at Journal of Polymers and the Environment. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
hossein danafar
Zanjan University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Nov, 2021
No community comments so far
Reviews received
Received 10 Nov, 2021
Reviewers invited
Invitations sent on 10 Nov, 2021
Editor assigned
On 03 Nov, 2021
First submitted
On 31 Oct, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
In this work, first, copper oxide nanoparticles (CUO NPs) were synthesized by physical methods and then coated with the bovine serum albumin (BSA) via biologically meditated minerals to form [email protected] NPs. Finally, curcumin (CUR) as an anticancer drug were immobilized on the surface of [email protected] NPS. The properties of [email protected] NPS were investigated by FTIR, UV-Vis, TEM, and AFM spectroscopes. It was found that the synthesized [email protected] nanoparticles were spherical with a particle size of 20 to 30 nm and have a sustained release of CUR at 37°C in buffer solution. Also, the result of release in biological environment showed that maximum drug release rate for this nanocarrier in pH 7.4 was measured 75% after 48 hours. The cytotoxicity of [email protected] on MDA-MB-231 cell line was studied. The results showed that [email protected] nanoparticles have significant cytotoxic activity on this cell line, while the results of MTT assay indicated the [email protected] NPs have no toxicity effect on the cancer cells.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
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