Subgroup analysis of the influence of body mass index on the association between serum lipids and cognitive function in Chinese population
Background: Previous studies reported that the association between lipid levels and cognitive function related with gender, age and specific cognitive domains, but the influence of body mass index (BMI) on this association is limited. This triggered our interest in exploring how serum lipids relate to cognitive function in different subgroups.
Methods: Data was collected from 2009 wave and 2015 wave of China Health and Nutrition Survey (CHNS). Multivariable linear regression analyses examined serum lipids level as predictors of sex- and age-specific measure of cognitive function in different BMI levels, which were adjusted for nationality, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking status, alcohol consumption and education level.
Results: Cognitive function score have different concentration curves in serum lipids quartile levels in different BMI categories. After adjustment for confounding factors, serum TG was positively associated with cognitive function score in underweight (β±SE: 2.06±0.88, P=0.023) and obese (β±SE: 1.44±0.71, P=0.045) male group, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 1.89±0.92, P=0.041) and obese (β±SE: 5.04±1.62, P=0.002) female group. Serum TC was negatively associated with cognitive function score in overweight (β±SE: -2.55±1.26, P=0.043) mid-life adults, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 2.15±0.94, P=0.022) and obese (β±SE: 5.33±2.07, P=0.011) older adults.
Conclusion: The associations of serum lipids with cognitive function were related with BMI levels and differed between gender and age groups. This result indicated that better nutritional status has superior cognitive function performance.
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Posted 29 May, 2020
On 21 May, 2020
Invitations sent on 21 May, 2020
On 21 May, 2020
Received 21 May, 2020
On 20 May, 2020
On 20 May, 2020
On 12 May, 2020
Received 10 May, 2020
On 24 Apr, 2020
Received 17 Apr, 2020
On 17 Apr, 2020
Received 17 Apr, 2020
On 27 Mar, 2020
On 05 Feb, 2020
Invitations sent on 04 Feb, 2020
On 23 Dec, 2019
On 22 Dec, 2019
On 22 Dec, 2019
On 22 Dec, 2019
Subgroup analysis of the influence of body mass index on the association between serum lipids and cognitive function in Chinese population
Posted 29 May, 2020
On 21 May, 2020
Invitations sent on 21 May, 2020
On 21 May, 2020
Received 21 May, 2020
On 20 May, 2020
On 20 May, 2020
On 12 May, 2020
Received 10 May, 2020
On 24 Apr, 2020
Received 17 Apr, 2020
On 17 Apr, 2020
Received 17 Apr, 2020
On 27 Mar, 2020
On 05 Feb, 2020
Invitations sent on 04 Feb, 2020
On 23 Dec, 2019
On 22 Dec, 2019
On 22 Dec, 2019
On 22 Dec, 2019
Background: Previous studies reported that the association between lipid levels and cognitive function related with gender, age and specific cognitive domains, but the influence of body mass index (BMI) on this association is limited. This triggered our interest in exploring how serum lipids relate to cognitive function in different subgroups.
Methods: Data was collected from 2009 wave and 2015 wave of China Health and Nutrition Survey (CHNS). Multivariable linear regression analyses examined serum lipids level as predictors of sex- and age-specific measure of cognitive function in different BMI levels, which were adjusted for nationality, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking status, alcohol consumption and education level.
Results: Cognitive function score have different concentration curves in serum lipids quartile levels in different BMI categories. After adjustment for confounding factors, serum TG was positively associated with cognitive function score in underweight (β±SE: 2.06±0.88, P=0.023) and obese (β±SE: 1.44±0.71, P=0.045) male group, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 1.89±0.92, P=0.041) and obese (β±SE: 5.04±1.62, P=0.002) female group. Serum TC was negatively associated with cognitive function score in overweight (β±SE: -2.55±1.26, P=0.043) mid-life adults, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 2.15±0.94, P=0.022) and obese (β±SE: 5.33±2.07, P=0.011) older adults.
Conclusion: The associations of serum lipids with cognitive function were related with BMI levels and differed between gender and age groups. This result indicated that better nutritional status has superior cognitive function performance.
Figure 1
Figure 2