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Subgroup analysis of the influence of body mass index on the association between serum lipids and cognitive function in Chinese population
Jiang Li
China-Japan Friendship Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1622-2623
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Previous studies reported that the association between lipid levels and cognitive function related with gender, age and specific cognitive domains, but the influence of body mass index (BMI) on this association is limited. This triggered our interest in exploring how serum lipids relate to cognitive function in different subgroups.
Methods: Data was collected from 2009 wave and 2015 wave of China Health and Nutrition Survey (CHNS). Multivariable linear regression analyses examined serum lipids level as predictors of sex- and age-specific measure of cognitive function in different BMI levels, which were adjusted for nationality, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking status, alcohol consumption and education level.
Results: Cognitive function score have different concentration curves in serum lipids quartile levels in different BMI categories. After adjustment for confounding factors, serum TG was positively associated with cognitive function score in underweight (β±SE: 2.06±0.88, P=0.023) and obese (β±SE: 1.44±0.71, P=0.045) male group, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 1.89±0.92, P=0.041) and obese (β±SE: 5.04±1.62, P=0.002) female group. Serum TC was negatively associated with cognitive function score in overweight (β±SE: -2.55±1.26, P=0.043) mid-life adults, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 2.15±0.94, P=0.022) and obese (β±SE: 5.33±2.07, P=0.011) older adults.
Conclusion: The associations of serum lipids with cognitive function were related with BMI levels and differed between gender and age groups. This result indicated that better nutritional status has superior cognitive function performance.
Keywords
Subgroup analysis, Body mass index, Cognitive function, Blood lipid profile, Chinese population, China Health and Nutrition Survey
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CURRENT STATUS: Under Review
Version 2
Posted 29 May, 2020
No community comments so far
Editor assigned
On 21 May, 2020
Reviewers invited
Invitations sent on 21 May, 2020
Reviewer #1 agreed
On 21 May, 2020
Review #1 received
Received 21 May, 2020
Submission checks complete
On 20 May, 2020
Editor invited
On 20 May, 2020
No comments provided
Editorial decision: Major revision
On 12 May, 2020
Review #3 received
Received 10 May, 2020
Reviewer #4 agreed
On 24 Apr, 2020
Review #1 received
Received 17 Apr, 2020
Reviewer #3 agreed
On 17 Apr, 2020
Review #2 received
Received 17 Apr, 2020
Reviewer #2 agreed
On 27 Mar, 2020
Reviewer #1 agreed
On 05 Feb, 2020
Reviewers invited
Invitations sent on 04 Feb, 2020
Editor assigned
On 23 Dec, 2019
First submitted
On 22 Dec, 2019
Submission checks complete
On 22 Dec, 2019
Editor invited
On 22 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nutrition & Dietetics
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This preprint is under consideration at Lipids in Health and Disease. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Subgroup analysis of the influence of body mass index on the association between serum lipids and cognitive function in Chinese population
Jiang Li
China-Japan Friendship Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1622-2623
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 2
Posted 29 May, 2020
No community comments so far
Editor assigned
On 21 May, 2020
Reviewers invited
Invitations sent on 21 May, 2020
Reviewer #1 agreed
On 21 May, 2020
Review #1 received
Received 21 May, 2020
Submission checks complete
On 20 May, 2020
Editor invited
On 20 May, 2020
No comments provided
Editorial decision: Major revision
On 12 May, 2020
Review #3 received
Received 10 May, 2020
Reviewer #4 agreed
On 24 Apr, 2020
Review #1 received
Received 17 Apr, 2020
Reviewer #3 agreed
On 17 Apr, 2020
Review #2 received
Received 17 Apr, 2020
Reviewer #2 agreed
On 27 Mar, 2020
Reviewer #1 agreed
On 05 Feb, 2020
Reviewers invited
Invitations sent on 04 Feb, 2020
Editor assigned
On 23 Dec, 2019
First submitted
On 22 Dec, 2019
Submission checks complete
On 22 Dec, 2019
Editor invited
On 22 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nutrition & Dietetics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Previous studies reported that the association between lipid levels and cognitive function related with gender, age and specific cognitive domains, but the influence of body mass index (BMI) on this association is limited. This triggered our interest in exploring how serum lipids relate to cognitive function in different subgroups.
Methods: Data was collected from 2009 wave and 2015 wave of China Health and Nutrition Survey (CHNS). Multivariable linear regression analyses examined serum lipids level as predictors of sex- and age-specific measure of cognitive function in different BMI levels, which were adjusted for nationality, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking status, alcohol consumption and education level.
Results: Cognitive function score have different concentration curves in serum lipids quartile levels in different BMI categories. After adjustment for confounding factors, serum TG was positively associated with cognitive function score in underweight (β±SE: 2.06±0.88, P=0.023) and obese (β±SE: 1.44±0.71, P=0.045) male group, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 1.89±0.92, P=0.041) and obese (β±SE: 5.04±1.62, P=0.002) female group. Serum TC was negatively associated with cognitive function score in overweight (β±SE: -2.55±1.26, P=0.043) mid-life adults, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 2.15±0.94, P=0.022) and obese (β±SE: 5.33±2.07, P=0.011) older adults.
Conclusion: The associations of serum lipids with cognitive function were related with BMI levels and differed between gender and age groups. This result indicated that better nutritional status has superior cognitive function performance.
Figure 1
Figure 2