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Research
Hui Liu
The First Affiliated Hospital of Jinan University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7422-6297
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study aimed to determine the bioactive compounds, core genes, and pharmacological mechanisms underlying the effects of Aidi injection (ADI) in non‐small cell lung cancer (NSCLC), and to provide a further research directions.
Material and Methods: The bioactive compounds of ADI were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and the Traditional Chinese Medicines Integrated Database, while targets related to these bioactive compounds and NSCLC were obtained from the GEO database. Cytoscape software was used to construct ingredients–protein-targets–pathway networks. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses and network analysis were performed to investigate potential mechanisms underlying the effects of ADI on NSCLC.
Results: This study screened 45 bioactive compounds and 38 major proteins of ADI as potential agents that can act against NSCLC. The results revealed the following potential therapeutic targets of ADI in the treatment of NSCLC: FOS, VEGFA, EGFR, JUN, MMP9, IL2, STAT1, CASP1, NFKBA, and CDK2. The potential mechanisms via which ADI acts against NSCLC are closely related to the inhibition of apoptosis and the activation of signaling pathways.
Conclusion: This study has revealed the multicompound, multitarget, and multichannel characteristics of ADI. This provides novel insight into further research investigations of the mechanism of ADI in NSCLC treatment.
Keywords
Medicine, Chinese Traditional, Pharmacologic Actions, Carcinoma, Non-Small-Cell Lung
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This is a list of supplementary files associated with this preprint. Click to download.
- Additionalfile1.doc
A list of the active compounds in ADI for network analysis
- Additionalfile1.doc
A list of the active compounds in ADI for network analysis
- Additionalfile1.doc
A list of the active compounds in ADI for network analysis
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Hui Liu
The First Affiliated Hospital of Jinan University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7422-6297
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 13 Nov, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study aimed to determine the bioactive compounds, core genes, and pharmacological mechanisms underlying the effects of Aidi injection (ADI) in non‐small cell lung cancer (NSCLC), and to provide a further research directions.
Material and Methods: The bioactive compounds of ADI were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and the Traditional Chinese Medicines Integrated Database, while targets related to these bioactive compounds and NSCLC were obtained from the GEO database. Cytoscape software was used to construct ingredients–protein-targets–pathway networks. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses and network analysis were performed to investigate potential mechanisms underlying the effects of ADI on NSCLC.
Results: This study screened 45 bioactive compounds and 38 major proteins of ADI as potential agents that can act against NSCLC. The results revealed the following potential therapeutic targets of ADI in the treatment of NSCLC: FOS, VEGFA, EGFR, JUN, MMP9, IL2, STAT1, CASP1, NFKBA, and CDK2. The potential mechanisms via which ADI acts against NSCLC are closely related to the inhibition of apoptosis and the activation of signaling pathways.
Conclusion: This study has revealed the multicompound, multitarget, and multichannel characteristics of ADI. This provides novel insight into further research investigations of the mechanism of ADI in NSCLC treatment.
Figure 1
Figure 1
Figure 1
Figure 2
Figure 2
Figure 2
Figure 3
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Figure 5
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Figure 8
Figure 8
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Figure 10
This is a list of supplementary files associated with this preprint. Click to download.
- Additionalfile1.doc
A list of the active compounds in ADI for network analysis
- Additionalfile1.doc
A list of the active compounds in ADI for network analysis
- Additionalfile1.doc
A list of the active compounds in ADI for network analysis
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