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Research Article
Huihui Liu
Nanjing University of Science and Technology
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2400-0286
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As one of the alternatives of 2,2-bis(4-hydroxyphenyl)propane (bisphenol A, BPA), 2,2-bis(4-hydroxyphenyl)butane (bisphenol B, BPB) has not gained sufficient concerns so far, due to the limited concentration and toxicity data available. In this study, the acute toxicity of BPB to three aquatic organisms, i.e., Tetradesmus obliquus, Daphnia magna and Danio rerio, was investigated, and it showed that Daphnia magna was the most sensitive organism with the half effective concentration (EC50) of 3.93 mg/L. Thereout, the screened Daphnia magna was exposed to BPB for 21 days to explore the chronic toxicity. Results indicated that BPB restricted the body length of parent Daphnia magna and reduced the total number of broods and neonates. The no-observed effect concentration of BPB to Daphnia magna was as low as 0.01 mg/L, which was two orders of magnitude lower than that reported 0.86–5.00 mg/L of BPA. Furthermore, the ecological risk of BPB was quantitatively assessed using the risk quotient (RQ) method. Obviously, although the environmental concentrations and detectable rate of BPB were much lower than that of BPA, its ecological risk was not necessarily lower. Hence, BPB should not be ignored in the future environmental monitoring and management.
Keywords
Bisphenol B, Bisphenol A, Acute toxicity, Chronic toxicity, Risk assessment
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CURRENT STATUS: Under Review
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Posted 22 Nov, 2021
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Received 19 Nov, 2021
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Editor invited
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Subject Areas
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This preprint is under consideration at Environmental Science and Pollution Research. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Huihui Liu
Nanjing University of Science and Technology
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2400-0286
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 22 Nov, 2021
No community comments so far
Reviews received
Received 19 Nov, 2021
Reviewers invited
Invitations sent on 19 Nov, 2021
Editor invited
On 18 Nov, 2021
Editor assigned
On 08 Nov, 2021
First submitted
On 03 Nov, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Toxicology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
As one of the alternatives of 2,2-bis(4-hydroxyphenyl)propane (bisphenol A, BPA), 2,2-bis(4-hydroxyphenyl)butane (bisphenol B, BPB) has not gained sufficient concerns so far, due to the limited concentration and toxicity data available. In this study, the acute toxicity of BPB to three aquatic organisms, i.e., Tetradesmus obliquus, Daphnia magna and Danio rerio, was investigated, and it showed that Daphnia magna was the most sensitive organism with the half effective concentration (EC50) of 3.93 mg/L. Thereout, the screened Daphnia magna was exposed to BPB for 21 days to explore the chronic toxicity. Results indicated that BPB restricted the body length of parent Daphnia magna and reduced the total number of broods and neonates. The no-observed effect concentration of BPB to Daphnia magna was as low as 0.01 mg/L, which was two orders of magnitude lower than that reported 0.86–5.00 mg/L of BPA. Furthermore, the ecological risk of BPB was quantitatively assessed using the risk quotient (RQ) method. Obviously, although the environmental concentrations and detectable rate of BPB were much lower than that of BPA, its ecological risk was not necessarily lower. Hence, BPB should not be ignored in the future environmental monitoring and management.
Figure 1
Figure 2
Figure 3
Figure 4
This is a list of supplementary files associated with this preprint. Click to download.
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