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Research article
Shu-Qin Chen
Sun Yat-sen University First Affiliated Hospital
Corresponding Author
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Purpose: To investigate the characteristics of deep infiltrating endometriosis (DIE) lesion distribution when associated with ovarian endometrioma (OEM).
Methods:The present study analyzed retrospective data obtained by the First Affiliated Hospital of Sun Yat-sen University, between June 2008 to June 2016. A total of 304 patients underwent laparoscopic surgery for complete removal of endometriosis by one experienced surgeon, and histological confirmation of OEM associated with DIE was conducted for each patient. Clinical data were recorded for each patient from medical, operative and pathological reports. Patients were then divided into two groups according to unilateral or bilateral OEM. Patients with unilateral OEM were subsequently divided into two subgroups according to OEM location (left- or right-hand side) and the diameter of the OEM (≤50 and >50 mm). The distribution characteristics of DIE lesions were then compared between the groups.
Results:DIE lesions were widely distributed, 30 anatomical sites were involved. Patients with associated unilateral OEM (n=184 patients) had a significantly increased number of DIE lesions when compared with patients with bilateral OEM (n=120 patients; 2.76±1.52 vs. 2.33±1.34; P=0.006). Compared with bilateral OEM with DIE, there was a higher rate of intestinal (39.1% vs. 18.3%; P<0.01) and vaginal (17.4% vs. 6.7%; P<0.01) infiltration by DIE lesions in unilateral OEM with DIE. The mean number of DIE lesions was not significantly correlated with the location or size of the OEM (2.83±1.56 vs. 2.74±1.53; P=0.678; and 2.65±1.42 vs. 2.80±1.43; P=0.518, respectively). There was no significant difference between the groups with OEM ≤50 mm and >50 mm.
Conclusion:Lesion distribution characteristics in women diagnosed with histologically proven OEM associated with DIE were frequently multifocal and severe.
Keywords
ovarian endometrioma, deep infiltrating endometriosis, lesion distribution characteristics
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View the published article at BMC Women's Health.
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Editorial decision: Minor revision
On 19 Apr, 2020
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Review #4 received
Received 14 Apr, 2020
Reviewer #5 agreed
On 22 Mar, 2020
Reviewer #3 agreed
On 18 Mar, 2020
Review #3 received
Received 18 Mar, 2020
Reviewer #4 agreed
On 18 Mar, 2020
Review #2 received
Received 17 Mar, 2020
Editor assigned
On 17 Mar, 2020
Reviewers invited
Invitations sent on 17 Mar, 2020
Reviewer #1 agreed
On 17 Mar, 2020
Reviewer #2 agreed
On 17 Mar, 2020
Review #1 received
Received 17 Mar, 2020
Submission checks complete
On 16 Mar, 2020
Editor invited
On 16 Mar, 2020
Version 1
Posted 02 Jan, 2020
No comments provided
Editorial decision: Major revision
On 04 Feb, 2020
Review #4 received
Received 24 Jan, 2020
Review #3 received
Received 24 Jan, 2020
Reviewer #7 agreed
On 04 Jan, 2020
Reviewer #6 agreed
On 30 Dec, 2019
Review #1 received
Received 30 Dec, 2019
Review #5 received
Received 30 Dec, 2019
Review #6 received
Received 30 Dec, 2019
Review #2 received
Received 30 Dec, 2019
Reviewers invited
Invitations sent on 30 Dec, 2019
Reviewer #1 agreed
On 30 Dec, 2019
Reviewer #2 agreed
On 30 Dec, 2019
Reviewer #3 agreed
On 30 Dec, 2019
Reviewer #4 agreed
On 30 Dec, 2019
Reviewer #5 agreed
On 30 Dec, 2019
First submitted
On 19 Dec, 2019
Editor assigned
On 19 Dec, 2019
Submission checks complete
On 18 Dec, 2019
Editor invited
On 18 Dec, 2019
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Subject Areas
Obstetrics & Gynecology
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A new preprint design is coming!
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See the published version of this preprint at BMC Women's Health.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Shu-Qin Chen
Sun Yat-sen University First Affiliated Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Women's Health.
No community comments so far
Editorial decision: Minor revision
On 19 Apr, 2020
Review #5 received
Received 19 Apr, 2020
Review #4 received
Received 14 Apr, 2020
Reviewer #5 agreed
On 22 Mar, 2020
Reviewer #3 agreed
On 18 Mar, 2020
Review #3 received
Received 18 Mar, 2020
Reviewer #4 agreed
On 18 Mar, 2020
Review #2 received
Received 17 Mar, 2020
Editor assigned
On 17 Mar, 2020
Reviewers invited
Invitations sent on 17 Mar, 2020
Reviewer #1 agreed
On 17 Mar, 2020
Reviewer #2 agreed
On 17 Mar, 2020
Review #1 received
Received 17 Mar, 2020
Submission checks complete
On 16 Mar, 2020
Editor invited
On 16 Mar, 2020
Version 1
Posted 02 Jan, 2020
No comments provided
Editorial decision: Major revision
On 04 Feb, 2020
Review #4 received
Received 24 Jan, 2020
Review #3 received
Received 24 Jan, 2020
Reviewer #7 agreed
On 04 Jan, 2020
Reviewer #6 agreed
On 30 Dec, 2019
Review #1 received
Received 30 Dec, 2019
Review #5 received
Received 30 Dec, 2019
Review #6 received
Received 30 Dec, 2019
Review #2 received
Received 30 Dec, 2019
Reviewers invited
Invitations sent on 30 Dec, 2019
Reviewer #1 agreed
On 30 Dec, 2019
Reviewer #2 agreed
On 30 Dec, 2019
Reviewer #3 agreed
On 30 Dec, 2019
Reviewer #4 agreed
On 30 Dec, 2019
Reviewer #5 agreed
On 30 Dec, 2019
First submitted
On 19 Dec, 2019
Editor assigned
On 19 Dec, 2019
Submission checks complete
On 18 Dec, 2019
Editor invited
On 18 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Obstetrics & Gynecology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Women's Health.
Purpose: To investigate the characteristics of deep infiltrating endometriosis (DIE) lesion distribution when associated with ovarian endometrioma (OEM).
Methods:The present study analyzed retrospective data obtained by the First Affiliated Hospital of Sun Yat-sen University, between June 2008 to June 2016. A total of 304 patients underwent laparoscopic surgery for complete removal of endometriosis by one experienced surgeon, and histological confirmation of OEM associated with DIE was conducted for each patient. Clinical data were recorded for each patient from medical, operative and pathological reports. Patients were then divided into two groups according to unilateral or bilateral OEM. Patients with unilateral OEM were subsequently divided into two subgroups according to OEM location (left- or right-hand side) and the diameter of the OEM (≤50 and >50 mm). The distribution characteristics of DIE lesions were then compared between the groups.
Results:DIE lesions were widely distributed, 30 anatomical sites were involved. Patients with associated unilateral OEM (n=184 patients) had a significantly increased number of DIE lesions when compared with patients with bilateral OEM (n=120 patients; 2.76±1.52 vs. 2.33±1.34; P=0.006). Compared with bilateral OEM with DIE, there was a higher rate of intestinal (39.1% vs. 18.3%; P<0.01) and vaginal (17.4% vs. 6.7%; P<0.01) infiltration by DIE lesions in unilateral OEM with DIE. The mean number of DIE lesions was not significantly correlated with the location or size of the OEM (2.83±1.56 vs. 2.74±1.53; P=0.678; and 2.65±1.42 vs. 2.80±1.43; P=0.518, respectively). There was no significant difference between the groups with OEM ≤50 mm and >50 mm.
Conclusion:Lesion distribution characteristics in women diagnosed with histologically proven OEM associated with DIE were frequently multifocal and severe.
The full text of this article is available to read as a PDF.
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