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Chuviruses belong to the genus Mivirus in the newly classified family Chuviridae, and their medical significance remains undetermined1,2. Here, we identified a novel chuvirus, Nuomin virus (NOMV), from febrile patients in China. NOMV had a circular genome and presented enveloped spherical particles with a diameter of approximately 120–150 nm. Phylogenetically, NOMV formed a separate clade in the Chuviridae family, with 17.1–83.4% sequence identity to other chuviruses. NOMV infection was confirmed in 54 patients who had a tick-bitten history during 2017–2019, while both virus-specific antibodies and RNA were tested negative in healthy cohorts. The typical symptoms are characterized by fever and headache. Seroconversion or a four-fold elevation of antibody titers was observed in the available specimens of convalescent phase. NOMV was also detected in hard ticks, sheep, and cattle in northeastern China. Our findings showed that a novel chuvirus is associated with human febrile illness in China, necessitating investigation of this emerging virus in the tick-endemic areas worldwide.
Keywords
chuvirus, Nuomin virus, human febrile illness, ticks
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This is a list of supplementary files associated with this preprint. Click to download.
- Supplementdata20201120177.docx
Supplemental Table S1-S6
- ExtendedData20201120177.pdf
Extended Data Fig. 1-7 and Table 1-9
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Letter
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 15 Dec, 2020
No community comments so far
Metrics
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PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Chuviruses belong to the genus Mivirus in the newly classified family Chuviridae, and their medical significance remains undetermined1,2. Here, we identified a novel chuvirus, Nuomin virus (NOMV), from febrile patients in China. NOMV had a circular genome and presented enveloped spherical particles with a diameter of approximately 120–150 nm. Phylogenetically, NOMV formed a separate clade in the Chuviridae family, with 17.1–83.4% sequence identity to other chuviruses. NOMV infection was confirmed in 54 patients who had a tick-bitten history during 2017–2019, while both virus-specific antibodies and RNA were tested negative in healthy cohorts. The typical symptoms are characterized by fever and headache. Seroconversion or a four-fold elevation of antibody titers was observed in the available specimens of convalescent phase. NOMV was also detected in hard ticks, sheep, and cattle in northeastern China. Our findings showed that a novel chuvirus is associated with human febrile illness in China, necessitating investigation of this emerging virus in the tick-endemic areas worldwide.
Figure 1
Figure 2
Figure 3
Figure 4
There is NO Competing Interest.
This is a list of supplementary files associated with this preprint. Click to download.
- Supplementdata20201120177.docx
Supplemental Table S1-S6
- ExtendedData20201120177.pdf
Extended Data Fig. 1-7 and Table 1-9
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