A 24-Year-Old Female With Anti-NMDA Receptor Encephalitis: A Case Report.

Background: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a form of autoimmune encephalitis with paraneoplastic and nonparaneoplastic origin. Patients with this disease usually arrive at the intensive care unit without any diagnosis or with complications as a result of a delayed diagnosis. This disease is not well known and is underdiagnosed. Due to the variability of the initial symptoms and the lack of knowledge regarding these symptoms, anti-NMDA receptor encephalitis is not only underdiagnosed but also can be misdiagnosed as viral encephalitis or other pathologies. Anti-NMDA receptor encephalitis preferentially affects children (from 8 months) and young adults, and it has a male/female ratio of 1/4. In case of clinical suspicion, electroencephalogram (EEG) and brain magnetic resonance imaging (MRI) are useful. The diagnosis is conrmed by the detection of IgG antibodies directed against NMDA receptors in serum and CSF. Treatment for this disease includes immunosuppression and tumour resection when indicated. Case presentation: We report the case of a 24-year-old female admitted to the emergency room following the onset of acute confusion. Due to the rapid deterioration of consciousness and swallowing disorders, the patient was transferred to the intensive care unit. On day 23 after presentation, MRI suggested autoimmune limbic encephalitis. Serologic and CSF results were positive for anti-NMDA antibodies. After IV methylprednisolone therapy and plasmapheresis and a second line therapy with corticosteroid therapy and mycophenolic acid, the patient’s clinical condition gradually improved. Conclusions: Anti-NMDA receptor encephalitis typically occurs in young patients with no history of acute psychiatric symptoms. The possibility of this pathology should be taken into account before diagnosing a patient with a psychiatric illness.


Background
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare autoimmune disease that is frequently underdiagnosed. The pathophysiology of this disease results from the binding of anti-NMDA antibodies to NMDA receptors, causing neuronal dysfunction and the disruption of fronto-striatal connections.
The clinical presentation of this disease is manifested by non-speci c in uenza syndrome. Subsequently, acute psychiatric symptoms appear, such as agitation, visual and auditory hallucinations, anxiety, emotional lability, and disorganized thoughts. Neurological deterioration typically occurs 1 to 3 weeks after the onset of symptoms, including abnormal movements, seizures and autonomic nervous system disorders. This clinical picture is often complicated by altered consciousness, swallowing disorders and respiratory distress, which requires intensive care.

Clinical Case
We report the case of a 24-year-old female Belgian patient with no signi cant history who was admitted to the emergency room following the onset of acute confusion and fear of imminent death. She was being treated with telithromycin for pharyngitis.
In the emergency room, she presented agitation, hallucinations, echolalia with ideas of death and aggression. The physical examination and additional medical examinations (biology, toxicology, electroencephalogram, brain scan) were normal. The patient was hospitalized for an additional assessment.
At rst, there was a spontaneous resolution of her psychiatric symptoms. Two days later, the reappearance of agitation, impulsive aggression, and visual hallucinations led to psychiatric hospitalization. After four days, her clinical condition worsened, including impaired consciousness, pyrexia, tachycardia, swallowing disorders and food refusal.
The patient was transferred to the emergency room for suspected neuroleptic malignant syndrome, but the health assessment was normal. Due to the deterioration of consciousness and swallowing disorders, the patient was transferred to the intensive care unit (ICU).
In the ICU, electroencephalogram and brain magnetic resonance imaging (MRI) ndings were normal.
Lumbar puncture revealed transparent cerebrospinal uid (CSF). Immunologic blood tests and CSF were sent to a university laboratory. Due to respiratory distress syndrome and severe bradycardia, the patient was intubated.
On day 23, a new Brain MRI uid-attenuated inversion recovery (FLAIR) was performed and showed the presence of a hyperintense signal on involving temporal and limbic lobes (see Fig. 1), suggesting autoimmune limbic encephalitis. Pulsed therapy with 1 g/d methylprednisolone was initiated, and neuroleptics were stopped.
The patient continued to develop dysautonomia disorders (low blood pressure, tachycardia, apnoea and Cheyne-Stokes respiration) as well as episodes of acute agitation.
A serologic test and CSF results showed the presence of speci c IgG oligoclonal bands and were positive for anti-NMDA antibodies. The 48-hour EEG did not demonstrate any epileptogenic activity. An oncology check-up was negative.
Finally, the patient bene ted from intraveinous methylprednisolone therapy as well as 10 plasmapheresis sessions, followed by oral corticosteroid therapy. The patient's clinical condition gradually improved, and she was transferred to the neurology department.
A neuropsychological and neurological assessment showed a pyramidal syndrome with proximal predominant left hemiparesis, a de cit in verbal uency and pathological denomination.
Clinical progress was slow but favourable with corticosteroid therapy and mycophenolic acid treatment.
The patient returned home after 56 days of hospitalization. At an 18-month follow-up, there was no recurrence, and the oncologic follow-up remained negative.
The origin of this disease is often paraneoplastic. Approximately 50% of women over 18 years old and only 9% of girls under 14 years old have an ovarian teratoma [4]. In men, the presence of tumours is rare [5].
The diagnosis of anti-NMDA receptor encephalitis should be discussed in the presence of a suggestive clinical picture and signs, such as lymphocytic pleocytosis and IgG oligoclonal bands in the CSF; abnormal EEG results in the majority of cases but nonspeci c with a slow and disorganized epileptic activity [6]. Brain MRI is often normal. In the study of Dalmau et al. [6] only 55% of patients had increased FLAIR or T2 signal in the cortical or subcortical areas (hippocampus, basal ganglia, white matter). The diagnosis is con rmed by the detection of IgG antibodies directed against the GluN1 subunits of the NMDA receptors in serum and CSF [7].
However, the diagnosis of anti-NMDA receptor encephalitis remains di cult due to the vagueness of the primary clinical picture. In a study [10] anti-NMDA antibodies are found in 50% of patients diagnosed with lethargic dyskinetic encephalitis. Additionally, 20-30% of patients with herpes simplex virus (HSV) infection show positive seroconversion with anti-NMDA antibodies as part of a relapse not attributable to HSV relapse [11].
In the absence of reliable statistical data, there is no standard treatment; instead, treatment should be individualized according to age, the severity of symptoms, and the presence or absence of a tumour.
Treatment can include immunosuppression and tumour resection when indicated [4]. Some therapeutic variants for the initial immunosuppressive treatment are recommended, including either an intravenous infusion of methylprednisolone (1 g/day for 5 days) or intravenous treatment with immunoglobulin G (400 mg/kg/day for 5 days) or plasmapheresis [12].
In the absence of clinical improvement, second-line treatment with rituximab (375 mg/m 2 /week for 4 weeks) or cyclophosphamide (750 mg/m 2 /month for 4 to 6 months) or a combination of both molecules can be proposed [12]. Mycophenolate mofetil can also be used as second line therapy. This drug has a selective antiproliferative activity on lymphocytes and has shown better e cacy in inducing remission. Furthermore it has less side effect pro le than cyclophosphamide in other autoimmune disorders [13].
Finally, for patients with severe and treatment-refractory disease, bortezomib [14] or tocilizumab [15] can be used as third-line therapy.
In addition, patients may require long-term care in intensive care from several weeks to several months as well as multidisciplinary rehabilitation.
NMDA anti-receptor IgG crosses the placental barrier, and its effects on the foetus can be variable; case of early neonatal death has been described previously [16].

Conclusion
Anti-NMDA receptor encephalitis typically occurs in young patients with no history of acute psychiatric symptoms. This disease is not well known and underdiagnosed due to the variability of the initial symptoms. Neurological deterioration typically occurs 1 to 3 weeks after the onset of symptoms, including abnormal movements, seizures and autonomic nervous system disorders. The origin is often paraneoplastic. In case of clinical suspicion, EEG and brain MRI are useful, but lumbar puncture for CSF analysis is used to con rm the diagnosis. Treatment includes immunosuppression and tumour resection when indicated. The possibility of this pathology should be taken into account before diagnosing a patient with a psychiatric illness. The patient give his content for all part of the material referenced here.

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Competing interests
Not applicable

Funding
The authors declare that they received no funding