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Research article
Verónica V. Olavarría
Clinica Alemana de Santiago SA
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4300-9921
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity.
Aim: To investigate the association of adherence to a Mediterranean diet and severity in a prospective hospital register of AIS patients.
Methods: We included AIS patients admitted from February 2017 to July 2019. All were assessed by a neurologist with a standard stroke protocol, including NIHSS. Adherence to Mediterranean diet was prospectively measured by the 14-point Mediterranean Diet Adherence Screener (MEDAS) and defined as low (0-6 points) or high (7-14 points). Demographic and clinical characteristics were compared by group with univariate analysis. A Generalized Linear Model (GLM) was used to investigate the association of admission NIHSS as a continuous ordinal variable and an ordinal logistic regression (OLR) analysis to determine the independent association of the NIHSS quartiles with adherence to Mediterranean diet.
Results: 368 patients were included, mean age 68.3 (17.7), 158 (42.9%) females. The median NIHSS score was 3 (IQR 1-9) and the median MEDAS score was 6 (IQR 4.5-8). Patients with high MEDAS scores had significantly lower; admission NIHSS scores, sedentary lifestyle, body mass index, total and LDL cholesterol levels, but higher alcohol consumption. After adjustments, high adherence to Mediterranean diet remained independently associated with lower stroke severity both in the GLM (β coefficient = -0.19, p=0.01) and in the OLR model (OR for lower NIHSS quartiles 0.6 (95% CI 0.37-0.98, p=0.04).
Conclusions: Higher pre-stroke adherence to a Mediterranean diet is independently associated with lower AIS severity.
Keywords
Mediterranean diet, adherence, ischemic stroke, acute stroke, severity
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CURRENT STATUS: Published
View the published article at BMC Neurology.
No community comments so far
Editorial decision: Accept
On 04 Jun, 2020
Editor assigned
On 29 May, 2020
Submission checks complete
On 28 May, 2020
Editor invited
On 28 May, 2020
Version 2
Posted 27 May, 2020
No comments provided
Editorial decision: Minor revision
On 26 May, 2020
Review #1 received
Received 21 May, 2020
Reviewers invited
Invitations sent on 18 May, 2020
Reviewer #1 agreed
On 18 May, 2020
Editor assigned
On 18 May, 2020
Submission checks complete
On 17 May, 2020
Editor invited
On 17 May, 2020
No comments provided
Editorial decision: Major revision
On 09 Apr, 2020
Review #2 received
Received 08 Feb, 2020
Reviewer #2 agreed
On 01 Feb, 2020
Review #1 received
Received 29 Jan, 2020
Reviewers invited
Invitations sent on 16 Jan, 2020
Reviewer #1 agreed
On 16 Jan, 2020
Editor assigned
On 13 Jan, 2020
Submission checks complete
On 31 Dec, 2019
Editor invited
On 31 Dec, 2019
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A new preprint design is coming!
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See the published version of this preprint at BMC Neurology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Verónica V. Olavarría
Clinica Alemana de Santiago SA
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4300-9921
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Neurology.
No community comments so far
Editorial decision: Accept
On 04 Jun, 2020
Editor assigned
On 29 May, 2020
Submission checks complete
On 28 May, 2020
Editor invited
On 28 May, 2020
Version 2
Posted 27 May, 2020
No comments provided
Editorial decision: Minor revision
On 26 May, 2020
Review #1 received
Received 21 May, 2020
Reviewers invited
Invitations sent on 18 May, 2020
Reviewer #1 agreed
On 18 May, 2020
Editor assigned
On 18 May, 2020
Submission checks complete
On 17 May, 2020
Editor invited
On 17 May, 2020
No comments provided
Editorial decision: Major revision
On 09 Apr, 2020
Review #2 received
Received 08 Feb, 2020
Reviewer #2 agreed
On 01 Feb, 2020
Review #1 received
Received 29 Jan, 2020
Reviewers invited
Invitations sent on 16 Jan, 2020
Reviewer #1 agreed
On 16 Jan, 2020
Editor assigned
On 13 Jan, 2020
Submission checks complete
On 31 Dec, 2019
Editor invited
On 31 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Neurology.
Background: High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity.
Aim: To investigate the association of adherence to a Mediterranean diet and severity in a prospective hospital register of AIS patients.
Methods: We included AIS patients admitted from February 2017 to July 2019. All were assessed by a neurologist with a standard stroke protocol, including NIHSS. Adherence to Mediterranean diet was prospectively measured by the 14-point Mediterranean Diet Adherence Screener (MEDAS) and defined as low (0-6 points) or high (7-14 points). Demographic and clinical characteristics were compared by group with univariate analysis. A Generalized Linear Model (GLM) was used to investigate the association of admission NIHSS as a continuous ordinal variable and an ordinal logistic regression (OLR) analysis to determine the independent association of the NIHSS quartiles with adherence to Mediterranean diet.
Results: 368 patients were included, mean age 68.3 (17.7), 158 (42.9%) females. The median NIHSS score was 3 (IQR 1-9) and the median MEDAS score was 6 (IQR 4.5-8). Patients with high MEDAS scores had significantly lower; admission NIHSS scores, sedentary lifestyle, body mass index, total and LDL cholesterol levels, but higher alcohol consumption. After adjustments, high adherence to Mediterranean diet remained independently associated with lower stroke severity both in the GLM (β coefficient = -0.19, p=0.01) and in the OLR model (OR for lower NIHSS quartiles 0.6 (95% CI 0.37-0.98, p=0.04).
Conclusions: Higher pre-stroke adherence to a Mediterranean diet is independently associated with lower AIS severity.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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