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Research Article
Rongxin Wang
Xuan Wu Hospital of the Capital Medical University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The etiology of reflux esophagitis (RE) is multi-factorial. This study aims to analyze the risk factors of the RE, its severity and further explore the impact of anxiety and depression on the patients' symptoms and quality of life.
Methods: From September 2016 to February 2018, a total of 689 subjects at Xuanwu Hospital Capital Medical University participated in the survey. They were divided into RE group (patients diagnosed as RE on gastroscopy, n = 361) and control group (healthy individuals without heartburn, regurgitation and other typical symptoms, n = 328). The survey included general demographic data, lifestyle habits, eating habits, GERD questionnaire (GerdQ), PHQ-9 depression scale and GAD-7 anxiety scale.
Results: The mean age and sex ratio of the two groups were similar. Multivariate logistic regression analysis showed that low education level, drinking strong tea, preference for sweets and acidic foods, overeating, short interval between dinner and sleep, anxiety, depression, sleeping on low pillow and constipation were independent risk factors for RE (p< 0.05). Ordinal logistic regression analysis showed positive correlation between sleeping on low pillow and the severity of RE (p=0.024). Depression had positive correlation with the severity of symptoms (rs=0.375，P<0.001) and the quality of life (rs=0.306，P<0.001), whereas anxiety had no such association.
Conclusions: Many lifestyle and eating habits are independent risk factors for the development of RE. Sleeping on low pillow was positively correlated with the severity of RE. Depression was positively related to the severity of symptoms and the quality of life.
Keywords
Reflux esophagitis, Depression, Anxiety, Lifestyle, Eating habits, Severity of reflux esophagitis
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CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
Version 1
Posted 02 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 05 Jan, 2021
Reviewers agreed
On 22 Dec, 2020
Reviews received
Received 20 Dec, 2020
Reviewers agreed
On 04 Dec, 2020
Reviewers invited
Invitations sent on 03 Dec, 2020
Editor assigned
On 30 Nov, 2020
Editor invited
On 26 Nov, 2020
Submission checks complete
On 26 Nov, 2020
First submitted
On 13 Nov, 2020
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Subject Areas
Gastroenterology & Hepatology
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A new preprint design is coming!
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See the published version of this preprint at BMC Gastroenterology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Rongxin Wang
Xuan Wu Hospital of the Capital Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
Version 1
Posted 02 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 05 Jan, 2021
Reviewers agreed
On 22 Dec, 2020
Reviews received
Received 20 Dec, 2020
Reviewers agreed
On 04 Dec, 2020
Reviewers invited
Invitations sent on 03 Dec, 2020
Editor assigned
On 30 Nov, 2020
Editor invited
On 26 Nov, 2020
Submission checks complete
On 26 Nov, 2020
First submitted
On 13 Nov, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Gastroenterology.
Background: The etiology of reflux esophagitis (RE) is multi-factorial. This study aims to analyze the risk factors of the RE, its severity and further explore the impact of anxiety and depression on the patients' symptoms and quality of life.
Methods: From September 2016 to February 2018, a total of 689 subjects at Xuanwu Hospital Capital Medical University participated in the survey. They were divided into RE group (patients diagnosed as RE on gastroscopy, n = 361) and control group (healthy individuals without heartburn, regurgitation and other typical symptoms, n = 328). The survey included general demographic data, lifestyle habits, eating habits, GERD questionnaire (GerdQ), PHQ-9 depression scale and GAD-7 anxiety scale.
Results: The mean age and sex ratio of the two groups were similar. Multivariate logistic regression analysis showed that low education level, drinking strong tea, preference for sweets and acidic foods, overeating, short interval between dinner and sleep, anxiety, depression, sleeping on low pillow and constipation were independent risk factors for RE (p< 0.05). Ordinal logistic regression analysis showed positive correlation between sleeping on low pillow and the severity of RE (p=0.024). Depression had positive correlation with the severity of symptoms (rs=0.375，P<0.001) and the quality of life (rs=0.306，P<0.001), whereas anxiety had no such association.
Conclusions: Many lifestyle and eating habits are independent risk factors for the development of RE. Sleeping on low pillow was positively correlated with the severity of RE. Depression was positively related to the severity of symptoms and the quality of life.
Figure 1
Figure 2
Figure 3
Figure 4
The full text of this article is available to read as a PDF.
This is a list of supplementary files associated with this preprint. Click to download.
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