Polymorphism, (number of studies)
|
G vs. A
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GG vs. AA
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AG vs. AA
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AG + GG vs. AA
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GG vs. AA + AG
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OR (95%CI), P-value, I2 (%), Ph
|
OR (95%CI), P-value, I2 (%), Ph
|
OR (95%CI), P-value, I2 (%), Ph
|
OR (95%CI), P-value, I2 (%), Ph
|
OR (95%CI), P-value, I2 (%), Ph
|
LTF rs1126478
|
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Ethnicity
|
|
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|
|
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Caucasian (2)
|
1.18 (0.66, 2.11), 0.58, 73, 0.05
|
1.49 (0.58, 3.85), 0.41, 55, 0.13
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1.02 (0.53, 1.97), 0.95, 53, 0.14
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1.16 (0.53, 1.97), 0.95, 0.53, 0.14
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1.33 (0.77, 2.29), 0.30, 6, 0.30
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Asian (2)
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0.96 (0.84, 1.09), 0.52, 0, 0.98
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0.97 (0.73, 1.29), 0.81, 0, 0.99
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1.07 (0.80, 1.43), 0.64, 0, 0.96
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1.02 (0.78, 1.33), 0.91, 0, 0.97
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0.92 (0.77, 1.10), 0.35, 0, 0.96
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Age group
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|
|
|
|
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Children (4)
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0.98 (0.87, 1.10), 0.68, 25, 0.26
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1.03 (0.80, 1.33), 0.82, 4, 0.37
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1.00 (0.80, 1.25), 0.99, 4, 0.44
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0.99 (0.81, 1.23), 0.96, 7, 0.36
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0.95 (0.80, 1.13), 0.58, 0, 0.45
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Control group
|
|
|
|
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Caries free (4)
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0.98 (0.87, 1.10), 0.68, 25, 0.26
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1.03 (0.80, 1.33), 0.82, 4, 0.37
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1.00 (0.80, 1.25), 0.99, 4, 0.44
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0.99 (0.81, 1.23), 0.96, 7, 0.36
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0.95 (0.80, 1.13), 0.58, 0, 0.45
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ENAM rs1264848
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Ethnicity
|
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Caucasian (4)
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0.86 (0.56, 1.32), 0.49, 80, 0.002
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0.67 (0.18, 2.45), 0.54, 82, 0.0009
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1.13 (0.80, 1.59), 0.48, 0, 0.45
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1.18 (0.86, 1.62), 0.31, 35, 0.20
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0.76 (0.34, 1.72), 0.51, 84, 0.0003
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Mixed (1)
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1.23 (0.79,1.91), 0.36
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1.62 (0.64, 4.09), 0.31
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1.73 (0.77, 3.90), 0.18
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1.69 (0.78, 3.68), 0.18
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1.09 (0.53, 2.23), 0.82
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Age group
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|
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Children (4)
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0.82 (0.57, 1.18), 0.28, 67, 0.03
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0.58 (0.19, 1.82), 0.35, 74, 0.01
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1.30 (0.84, 2.01), 0.26, 3, 0.36
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1.16 (0.76, 1.75), 0.49, 42, 0.16
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0.66 (0.37, 1.17), 0.15, 70, 0.02
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Control group
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|
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Caries free (3)
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0.79 (0.39, 1.63), 0.53, 86, 0.0006
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0.42 (0.03, 5.41), 0.51, 88, 0.0003
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1.00 (0.66, 1.51), 1.00, 0, 0.44
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0.74 (0.27, 2.02), 0.56, 55, 0.11
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0.66 (0.15, 2.95), 0.59, 89, <0.0001
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Low caries (2)
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1.03 (0.83, 1.29), 0.78, 0, 0.37
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1.30 (0.79, 2.14), 0.30, 0, 0.59
|
1.57 (0.97, 2.53), 0.07, 0, 0.76
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1.45 (0.92, 2.28), 0.11, 0, 0.62
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0.90 (0.66, 1.23), 0.51, 0, 0.57
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ENAM rs3796704
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Ethnicity
|
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Caucasian (3)
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1.43 (1.10, 1.85), 0.007, 45, 0.16
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2.49 (1.19, 5.24), 0.02, 0, 0.85
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1.74 (0.81, 3.74), 0.16, 0, 0.98
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2.16 (1.05, 4.45), 0.04, 0, 0.85
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1.41 (1.04, 1.91), 0.03, 45, 0.16
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Mixed (1)
|
1.11 (0.57, 2.15), 0.77
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0.27 (0.03, 2.47), 0.24
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0.14 (0.01, 1.46), 0.10
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0.24 (0.03, 2.17), 0.20
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1.43 (0.67, 3.05), 0.36
|
Age group
|
|
|
|
|
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Children (2)
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1.46 (0.92, 2.32), 0.11, 22, 0.26
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0.61 (0.13, 2.93), 0.54, 38, 0.20
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0.35 (0.07, 1.74), 0.20, 35, 0.22
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0.54 (0.11, 2.56), 0.44, 37, 0.21
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1.71 (1.02, 2.85), 0.04, 0, 0.53
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Control group
|
|
|
|
|
|
Caries free (2)
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1.62 (1.21, 2.17), 0.001, 0, 0.59
|
2.499 (1.19, 5.24), 0.02, 0, 0.85
|
1.74 (0.81, 3.74), 0.16, 0, 0.98
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2.16 (1.05, 4.45), 0.04, 0, 0.85
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1.67 (1.17, 2.39), 0.0050, 0.58
|
Low caries (2)
|
0.97 (0.63, 1.50), 0.89, 0, 0.61
|
0.27 (0.03, 2.47), 0.24
|
0.14 (0.01, 1.46), 0.10
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0.24 (0.03, 2.17), 0.20
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1.05 (0.66, 1.68), 0.83, 0, 0.32
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Polymorphism, (number of studies)
|
T vs. C
|
TT vs. CC
|
CT vs. CC
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CT + TT vs. CC
|
TT vs. CC + CT
|
OR (95%CI), P-value, I2 (%), Ph
|
OR (95%CI), P-value, I2 (%), Ph
|
OR (95%CI), P-value, I2 (%), Ph
|
OR (95%CI), P-value, I2 (%), Ph
|
OR (95%CI), P-value, I2 (%), Ph
|
ENAM rs3796703
|
|
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Ethnicity
|
|
|
|
|
|
Asian (2)
|
0.92 (0.24, 3.58), 0.91, 78, 0.03
|
5.22 (0.25, 108.96), 0.29
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0.89 (0.23, 3.48), 0.87, 77, 0.04
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0.90 (0.23, 3.63), 0.89, 78, 0.03
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2.90 (0.92, 9.12), 0.07, 0, 0.69
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Age group
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|
|
|
|
|
Children (2)
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0.92 (0.24, 3.58), 0.91, 78, 0.03
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5.22 (0.25, 108.96), 0.29
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0.89 (0.23, 3.48), 0.87, 77, 0.04
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0.90 (0.23, 3.63), 0.89, 78, 0.03
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2.90 (0.92, 9.12), 0.07, 0, 0.69
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AMELX rs946252
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Ethnicity
|
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Caucasian (2)
|
0.95 (0.35, 2.55), 0.92, 69, 0.07
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1.42 (0.54, 3.76), 0.48, 17, 0.27
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2.80 (0.93, 8.43), 0.07, 0, 0.38
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1.63 (0.67, 4.01), 0.28, 0, 0.42
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0.73 (0.19, 2.87), 0.66, 67, 0.08
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Mixed (1)
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0.99 (0.53, 1.86), 0.98
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1.03 (0.28, 3.75), 0.96
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0.95 (0.40, 2.25), 0.91
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0.98 (0.46, 2.07), 0.95
|
1.04 (0.29, 3.75), 0.95
|
Age group
|
|
|
|
|
|
Children (2)
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1.21 (0.77,1.91), 0.42, 0, 0.37
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1.54 (0.61, 3.92), 0.36, 0, 0.37
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1.24 (0.61, 2.49), 0.56, 5, 0.31
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1.24 (0.66, 2.33), 0.50, 24, 0.25
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1.26 (0.56, 2.83), 0.25
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Control group
|
|
|
|
|
|
Caries free (2)
|
0.95 (0.35, 2.55), 0.92, 69, 0.07
|
1.42 (0.54, 3.76), 0.48, 17, 0.27
|
2.80 (0.93, 8.43), 0.07, 0, 0.38
|
1.63 (0.67, 4.01), 0.28, 0, 0.42
|
0.73 (0.19, 2.87), 0.66, 67, 0.08
|
Low caries (1)
|
0.99 (0.53, 1.86), 0.98
|
1.03 (0.28, 3.75), 0.96
|
0.95 (0.40, 2.25), 0.91
|
0.98 (0.46, 2.07), 0.95
|
1.04 (0.29, 3.75), 0.95
|
AMELX rs17878486
|
|
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|
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Ethnicity
|
|
|
|
|
|
Caucasian (2)
|
2.87 (0.35, 23.23), 0.32, 95, <0.0001
|
5.12 (0.09, 278.85), 0.42, 93, 0.0002
|
1.00 (0.12, 8.23), 1.00, 0.81, 0.02
|
2.03 (0.10, 42.44), 0.65, 92, 0.0004
|
6.17 (0.41, 92.05), 0.19, 91, 0.001
|
Asian (1)
|
1.38 (0.25, 7.75), 0.71
|
0.93 (0.04, 23.52), 0.97
|
0.33 (0.01, 12.82), 0.56
|
0.89 (0.04, 22.53), 0.95
|
1.89 (0.30, 11.85), 0.50
|
Mixed (1)
|
1.87 (1.06, 3.30), 0.03
|
3.82 (1.19, 12.21), 0.02
|
5.11 (1.33, 19.72), 0.02
|
4.03 (1.27, 12.75), 0.02
|
1.39 (0.69, 2.80), 0.35
|
Age group
|
|
|
|
|
|
Children (3)
|
2.48 (0.76, 8.05), 0.13, 90, <0.0001
|
4.69 (0.55, 40.16), 0.16, 86, 0.0007
|
1.72 (0.37, 7.92), 0.48, 75, 0.02
|
2.65 (0.49, 14.35), 0.26, 84, 0.002
|
3.55 (0.72, 17.60), 0.12, 87, 0.0004
|
Adults (1)
|
1.38 (0.25, 7.75), 0.71
|
0.93 (0.04, 23.52), 0.97
|
0.33 (0.01, 12.82), 0.56
|
0.89 (0.04, 22.53), 0.95
|
1.89 (0.30, 11.58), 0.50
|
Control group
|
|
|
|
|
|
Caries free (2)
|
2.87 (0.35, 23.23), 0.32, 95, <0.0001
|
5.12 (0.09, 278.85), 0.42, 93, 0.0002
|
1.00 (0.12, 8.23), 1.00, 0.81, 0.02
|
2.03 (0.10, 42.44), 0.65, 92, 0.0004
|
6.17 (0.41, 92.05), 0.19, 91, 0.001
|
Low caries (2)
|
1.82 (1.06, 3.11), 0.03, 0, 0.74
|
3.28 (1.14, 9.43), 0.03, 0, 0.42
|
3.42 (1.04, 11.28), 0.04, 47, 0.17
|
3.43 (1.21, 9.75), 0.02, 0, 0.39
|
1.44 (0.75, 2.77), 0.27, 0, 0.76
|
AMELX rs6639060
|
|
|
|
|
|
Ethnicity
|
|
|
|
|
|
Caucasian (1)
|
1.08 (0.63, 1.85), 0.78
|
1.04 (0.43, 2.51), 0.94
|
1.27 (0.49,3.30), 0.63
|
1.14 (0.56, 2.29), 0.72
|
1.00 (0.42, 2.39), 1.00
|
Age group
|
|
|
|
|
|
Adults (1)
|
1.08 (0.63, 1.85), 0.78
|
1.04 (0.43, 2.51), 0.94
|
1.27 (0.49,3.30), 0.63
|
1.14 (0.56, 2.29), 0.72
|
1.00 (0.42, 2.39), 1.00
|
AMELX rs2106416
|
|
|
|
|
|
Ethnicity
|
|
|
|
|
|
Caucasian (2)
|
1.25 (0.77, 2.03), 0.37, 30, 0.23
|
1.83 (0.47, 7.06), 0.38, 40, 0.20
|
1.20 (0.65, 2.22), 0.56, 0, 0.54
|
1.25 (0.69, 2.27), 0.46, 0, 0.35
|
1.67 (0.44, 6.34), 0.45, 31, 0.23
|
Age group
|
|
|
|
|
|
Children (3)
|
0.59 (0.16, 2.11), 0.41, 82, 0.003
|
1.83 (0.47, 7.06), 0.38, 40, 0.20
|
0.55 (0.13, 2.25), 0.40, 80, 0.006
|
0.59 (0.15, 2.31), 0.45, 79, 0.008
|
1.67 (0.44, 6.34), 0.45, 31, 0.23
|