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Research article
Antonio Cuesta Vargas
Universidad de Malaga
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8880-4315
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Subjects with mild cognitive impairment (MCI) experience alterations of functional parameters, such as impaired balance or gait. The current systematic review set out to investigate whether functional objective performance may predict a future risk of MCI; to compare functional objective parameters in confirmed MCI people with a control group; and to assess longitudinal changes in these parameters after different physical interventions.
Methods
A systematic review of relevant literature was conducted. Literature were searched in PubMed, AMED, CINAHL, EMBASE, PEDro and Web of Science as well as grey literature databases. Cohort studies and Randimized Controlled Trials (RCTs) were included. Quality of reviewed studies were assessed independently by reviewers using quality assessment checklists.
Results
Fifteen studies met inclusion criteria including mild cognitive impairment people. Results from RCTs suggested that gait speed, gait variability and balance may be improved by different physical interventions. Cohort studies showed that gait speed, gait variability and gait symmetry, especially in Dual Task (DT) conditions, were parameters impaired in confirmed MCI patients in comparison with a Control Gorup. Furthermore, cohort studies suggested that gait variability could be a predictor of MCI. However, RCTs showed an unclear risk of bias and all studies included in this systematic review had a low quality of evidence.
Conclusions
Existing studies suggest that gait variability may predict incident MCI, moreover different gait parameters, especially during DT conditions, could be impaired in MCI. These parameters could be improved by some interventions. Further studies are required to refute our findings.
Keywords
Mild cognitive impairment, functional objective parameters, instrumented assessment, kinematics, gait, balance
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Geriatrics.
No community comments so far
Editorial decision: Major revision
On 08 Apr, 2020
Review #2 received
Received 04 Apr, 2020
Review #1 received
Received 03 Apr, 2020
Review #3 received
Received 29 Mar, 2020
Reviewer #3 agreed
On 26 Mar, 2020
Reviewer #1 agreed
On 25 Mar, 2020
Reviewer #2 agreed
On 25 Mar, 2020
Reviewers invited
Invitations sent on 25 Mar, 2020
Editor assigned
On 03 Mar, 2020
Submission checks complete
On 02 Mar, 2020
Editor invited
On 02 Mar, 2020
Version 1
Posted 08 Jan, 2020
No comments provided
Editorial decision: Major revision
On 12 Feb, 2020
Review #2 received
Received 30 Jan, 2020
Review #1 received
Received 23 Jan, 2020
Review #3 received
Received 23 Jan, 2020
Reviewer #3 agreed
On 12 Jan, 2020
Reviewer #2 agreed
On 09 Jan, 2020
Reviewers invited
Invitations sent on 08 Jan, 2020
Reviewer #1 agreed
On 08 Jan, 2020
Editor assigned
On 16 Dec, 2019
Submission checks complete
On 15 Dec, 2019
Editor invited
On 15 Dec, 2019
First submitted
On 13 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Geriatrics & Gerontology
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Geriatrics.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Antonio Cuesta Vargas
Universidad de Malaga
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8880-4315
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Geriatrics.
No community comments so far
Editorial decision: Major revision
On 08 Apr, 2020
Review #2 received
Received 04 Apr, 2020
Review #1 received
Received 03 Apr, 2020
Review #3 received
Received 29 Mar, 2020
Reviewer #3 agreed
On 26 Mar, 2020
Reviewer #1 agreed
On 25 Mar, 2020
Reviewer #2 agreed
On 25 Mar, 2020
Reviewers invited
Invitations sent on 25 Mar, 2020
Editor assigned
On 03 Mar, 2020
Submission checks complete
On 02 Mar, 2020
Editor invited
On 02 Mar, 2020
Version 1
Posted 08 Jan, 2020
No comments provided
Editorial decision: Major revision
On 12 Feb, 2020
Review #2 received
Received 30 Jan, 2020
Review #1 received
Received 23 Jan, 2020
Review #3 received
Received 23 Jan, 2020
Reviewer #3 agreed
On 12 Jan, 2020
Reviewer #2 agreed
On 09 Jan, 2020
Reviewers invited
Invitations sent on 08 Jan, 2020
Reviewer #1 agreed
On 08 Jan, 2020
Editor assigned
On 16 Dec, 2019
Submission checks complete
On 15 Dec, 2019
Editor invited
On 15 Dec, 2019
First submitted
On 13 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Geriatrics & Gerontology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Geriatrics.
Background
Subjects with mild cognitive impairment (MCI) experience alterations of functional parameters, such as impaired balance or gait. The current systematic review set out to investigate whether functional objective performance may predict a future risk of MCI; to compare functional objective parameters in confirmed MCI people with a control group; and to assess longitudinal changes in these parameters after different physical interventions.
Methods
A systematic review of relevant literature was conducted. Literature were searched in PubMed, AMED, CINAHL, EMBASE, PEDro and Web of Science as well as grey literature databases. Cohort studies and Randimized Controlled Trials (RCTs) were included. Quality of reviewed studies were assessed independently by reviewers using quality assessment checklists.
Results
Fifteen studies met inclusion criteria including mild cognitive impairment people. Results from RCTs suggested that gait speed, gait variability and balance may be improved by different physical interventions. Cohort studies showed that gait speed, gait variability and gait symmetry, especially in Dual Task (DT) conditions, were parameters impaired in confirmed MCI patients in comparison with a Control Gorup. Furthermore, cohort studies suggested that gait variability could be a predictor of MCI. However, RCTs showed an unclear risk of bias and all studies included in this systematic review had a low quality of evidence.
Conclusions
Existing studies suggest that gait variability may predict incident MCI, moreover different gait parameters, especially during DT conditions, could be impaired in MCI. These parameters could be improved by some interventions. Further studies are required to refute our findings.
This is a list of supplementary files associated with this preprint. Click to download.
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