See the published version of this preprint at Reproductive Biology and Endocrinology.
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Short communication
Gabriel Chodick
Maccabi Healthcare Services
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5189-8995
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Several studies from the US and Europe have shown a population-level decline in serum testosterone in men from 1970's to early 2000's. However, to the best of our knowledge, no study examining population-level decline in testosterone has been published in more recent years. The study objective was therefore to examine secular trends in testosterone levels among Israeli men in the first and second decades of the 21 st century,
Methods
All incident total testosterone performed between1/2006 and 3/2019 among 102,334 male members of a large health organization.
Results A prominent trend of age-independent decline in the testosterone levels for most age groups. The results were highly significant ( Common.EditSubmissionSteps.Transform.EquationText )
Conclusions
The results show a highly significant age-independent decline in total testosterone that is unlikely to be explained by increasing rates of obesity.
Keywords
Testosterone, Secular trends, Israel
Figure 1
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at Reproductive Biology and Endocrinology.
No community comments so far
Editorial decision: Accept
On 15 Feb, 2020
Review #1 received
Received 12 Feb, 2020
Reviewer #2 agreed
On 31 Jan, 2020
Review #2 received
Received 31 Jan, 2020
Reviewer #1 agreed
On 29 Jan, 2020
Reviewers invited
Invitations sent on 29 Jan, 2020
Editor assigned
On 28 Jan, 2020
Submission checks complete
On 27 Jan, 2020
Editor invited
On 27 Jan, 2020
Version 1
Posted 08 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 23 Jan, 2020
Review #3 received
Received 22 Jan, 2020
Review #2 received
Received 22 Jan, 2020
Review #1 received
Received 19 Jan, 2020
Reviewer #3 agreed
On 16 Jan, 2020
Reviewer #2 agreed
On 08 Jan, 2020
Editor assigned
On 07 Jan, 2020
Reviewers invited
Invitations sent on 07 Jan, 2020
Reviewer #1 agreed
On 07 Jan, 2020
Submission checks complete
On 06 Jan, 2020
Editor invited
On 06 Jan, 2020
First submitted
On 05 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Reproductive Biology and Endocrinology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Short communication
Gabriel Chodick
Maccabi Healthcare Services
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5189-8995
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Reproductive Biology and Endocrinology.
No community comments so far
Editorial decision: Accept
On 15 Feb, 2020
Review #1 received
Received 12 Feb, 2020
Reviewer #2 agreed
On 31 Jan, 2020
Review #2 received
Received 31 Jan, 2020
Reviewer #1 agreed
On 29 Jan, 2020
Reviewers invited
Invitations sent on 29 Jan, 2020
Editor assigned
On 28 Jan, 2020
Submission checks complete
On 27 Jan, 2020
Editor invited
On 27 Jan, 2020
Version 1
Posted 08 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 23 Jan, 2020
Review #3 received
Received 22 Jan, 2020
Review #2 received
Received 22 Jan, 2020
Review #1 received
Received 19 Jan, 2020
Reviewer #3 agreed
On 16 Jan, 2020
Reviewer #2 agreed
On 08 Jan, 2020
Editor assigned
On 07 Jan, 2020
Reviewers invited
Invitations sent on 07 Jan, 2020
Reviewer #1 agreed
On 07 Jan, 2020
Submission checks complete
On 06 Jan, 2020
Editor invited
On 06 Jan, 2020
First submitted
On 05 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Reproductive Biology and Endocrinology.
Background
Several studies from the US and Europe have shown a population-level decline in serum testosterone in men from 1970's to early 2000's. However, to the best of our knowledge, no study examining population-level decline in testosterone has been published in more recent years. The study objective was therefore to examine secular trends in testosterone levels among Israeli men in the first and second decades of the 21 st century,
Methods
All incident total testosterone performed between1/2006 and 3/2019 among 102,334 male members of a large health organization.
Results A prominent trend of age-independent decline in the testosterone levels for most age groups. The results were highly significant ( Common.EditSubmissionSteps.Transform.EquationText )
Conclusions
The results show a highly significant age-independent decline in total testosterone that is unlikely to be explained by increasing rates of obesity.
Figure 1
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