Cumulative Triglyceride-glucose Index Is a Risk for CVD: A Prospective Cohort Study

doi:10.21203/rs.3.rs-1106485/v1

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Research Article

Cumulative Triglyceride-glucose Index Is a Risk for CVD: A Prospective Cohort Study

https://doi.org/10.21203/rs.3.rs-1106485/v1

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published 10 Feb, 2022

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Background Previous studies has shown a significant relationship between baseline triglyceride-glucose (TyG) index and cardiovascular disease (CVD). However, the long-term effect of TyG index and incident CVD remains uncertain. This study aimed to investigate the association between cumulative TyG index and the risk of CVD.

Method In this study, we recruited individuals participating in Kailuan Study from 2006 to 2013 without stroke, myocardial infarction, and cancer in the four consecutive examinations. Cumulative TyG index was calculated by multiplying the average TyG index and the time between the two consecutive examinations. Cumulative TyG index levels were categorized into four quartile groups: Q1 group, ≤50.65 (as reference group), Q2 group, 50.65-53.86, Q3 group, 53.86-57.44, Q4 group, ＞57.44. The effect of Cumulative TyG index on CVD incidence was estimated by multivariable-adjusted Cox proportional hazard models.

Result A total of 44,087 individuals participated in the final analysis. After a mean follow-up of 6.52±1.14 years, incident CVD, MI and stroke occurred in 2057, 395 and 1695, respectively. The multivariable-adjusted COX regression model showed the HR (95% CI) of CVD were Q2 1.25(1.08-1.44), Q3 1.22(1.05-1.40) and Q4 1.39(1.21-1.61), compared to Q1 group. Consistent results were obtained in the subgroup analyses and sensitivity analyses.

Conclusion Cumulative TyG index was associated with increased risk of CVD. Maintaining a healthy level of TyG index within the desirable range and better control of cumulative TyG index is important for prevention of CVD.

Cardiac & Cardiovascular Systems

triglyceride-glucose index

cardiovascular disease

cumulative exposure

cohort study

prevention

According to epidemiological studies, cardiovascular disease (CVD) is still the leading cause of morbidity and mortality among chronic non-communicable diseases globally. Despite improvement in CVD outcomes following the progress of living standards and medical levels, the high incidence of CVD remains a major health concern [1]. Chronic conditions such as diabetes mellitus and hypertension are major modifiable risk factors contributing to the current epidemic of CVD [2,3]. In addition, the burden of CVD is compounded further by unhealthy behavioral factors (including smoking, sedentary, obesity), and these risk factors also exacerbate the risk of mortality [4]. Thus, identifying effective preventive strategies for CVD has become a global public health priority.

Epidemiological and pathophysiological studies suggest that insulin resistance (IR) may be largely responsible for vascular endothelial dysfunction and CVD [5,6]. The triglyceride-glucose (TyG) index is calculated using fasting blood glucose (FBG) and triglyceride (TG) levels, and it has been reported to be significantly correlated with IR and to be a simple and reliable surrogate marker of IR [7]. Moreover, several cohort studies have suggested that TyG index was a risk factor for development of CVD [8-10]. TyG index is a dynamic condition that changes over time, but previous results might be due to the limited sample size and short follow-up periods, and there remains uncertainty about the associations with the cumulative effect of TyG index and incident CVD. Those features do not take into account the exposure time of each TyG index and the risk that those features may convey.

Therefore, in the present study, we investigated to determine the impact of cumulative TyG index, a measure which incorporates both the levels of TyG index and the duration of the exposure elevated TyG index, on the risk of developing CVD by using a large community-based prospective study cohort from Kailuan Study.

Study participants

The Kailuan Study is an ongoing prospective community-based cohort study conducted in Tangshan, China. All participants in the Kailuan Study are employees and retirees of the Kailuan Group. Details of the study design and procedure have been described elsewhere [11]. At baseline, 101,510 participants (81,110 males and 20,400 females; aged 18-98 years) were recruited, underwent clinical and laboratory examinations, and completed a questionnaire interview (June 2006 to October 2007) at 11 hospitals affiliated with the Kailuan Group. Subsequent examinations involving anthropometric, cardiovascular risk factor measures, and self-reported questionnaires (including income, educational level, drinking and so on) occurred approximately biennially after baseline until December 2017 (2008/09, 2010/11, 2012/13, 2014/15 and 2016/17). For our investigation, participants were eligible if they attended three consecutive examinations between the second (2008/09), the third (2010/11) and the fourth (2012/13) examinations. Participants were excluded if they had prevalent myocardial infarction (MI), stroke or cancer, respectively, in or prior to 2012, or missing data on FBG or TG at any of the examinations, or BMI >45 kg/m² at any of the examinations. Ultimately, a total of 44,087 participants were enrolled in the present study (Fig. 1).

The study was conducted in accordance with the guidelines of the Declaration of Helsinki and was approved by the Kailuan General Hospital Ethics Committee. All the participants agreed to take part in the study and provided written informed consent.

Data collection and definitions

Information on demographic and clinical characteristics (age, sex, lifestyle, and past medical history, etc.) were collected using a self-reported questionnaire, as detailed elsewhere [12]. Education level was classified as primary school or below, middle school, and high school or above. Smoking and drinking status were classified as yes or no. Active physical activity was defined as “>4 times per week and 20 min at time”. BMI was calculated as the weigh (kg)/height² (m²).

Elbow venous blood samples of 5 mL were collected into an anticoagulant tube containing EDTA between 7:00–9:00 am after overnight fasting for at least 8 h, and the serum was collected after centrifugation at 3000 × g for 10 min. The supernatant was measured within 4 h. All biochemical measurement including TG, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), high-sensitive C-reactive protein (Hs-CRP), FBG, and Uric acid (UA), and etc. was measured on the Hitachi 747 autoanalyzer (Hitachi, Tokyo, Japan).

Hypertension was defined as SBP≥140 mmHg or DBP≥90 mmHg, a self-reported history of hypertension, or any use of antihypertensive medication. Diabetes was defined as FBG≥7.0 mmol/L, a self-reported history of diabetes, or use of antidiabetic medication.

Cumulative TyG index

The TyG index was calculated as ln (fasting TG [mg/dL]×FBG [mg/dL]/2), as previously reported [13]. Cumulative TyG index was defined as the summation of average TyG index for each pair of consecutive examinations multiplied by the time between these two consecutive visits in years:

[(TyG index₂₀₀₆+ TyG index₂₀₀₈)/2*time_1-2]+[( TyG index₂₀₀₈+ TyG index₂₀₁₀)/2*time_2-3]+[( TyG index₂₀₁₀+ TyG index₂₀₁₂)/2*time_3-4]

where TyG index₂₀₀₆, TyG index₂₀₀₈, TyG index₂₀₁₀, and TyG index₂₀₁₂ indicate the TyG index at the baseline, second, third and fourth examinations, and time_1-2, time_2-3 and time_3-4 indicate the participant-specific time intervals between consecutive visits in years. The means of time_1-2, time_2-3 and time_3-4 were 2.06 years, 1.95 years and 2.22 years. The participants were stratified by quartile of cumulative TyG index: Q1 group, ≤50.65 (as reference group), Q2 group, 50.65-53.86, Q3 group, 53.86-57.44, Q4 group, ＞57.44.

According to previous studies, adults with a higher TyG index experience an increased risk of CVD, in the current analysis, participants with a fourth quartile of TyG index (＞9.02) at each examination were identified to be in the higher TyG index exposure group[9]. TyG index exposure duration was defined as the times of examinations with higher TyG index among the 4 examinations, quantified as 0 years (never had higher TyG index), 2 years (had higher TyG index once), 4 years (had higher TyG index twice), 6 years (had higher TyG index third), and 8 years (had higher TyG index at all 4 study examinations).

Assessment of CVD

Follow-up ended at the first record of CVD event, all-cause death or at the end of follow-up on 31 December 2019, whichever came first. The types of CVD included MI and stroke. We used ICD-10th revision codes to identify CVD cases (I21 for MI, I6 for stroke)[14,15]. The database of CVD diagnoses was obtained from the Municipal Social Insurance Institution and Hospital Discharge Register and was updated annually during the follow-up period. An expert panel collected and reviewed annual discharges records from 11 local hospitals to identify patients who were suspected of CVD. The diagnosis of MI was determined by the patient’s clinical symptoms, electrocardiogram, and dynamic changes of myocardial enzyme following the World Health Organization’s Multinational Monitoring of Trends and Determinants in Cardiovascular Disease criteria[16]. Stroke was diagnosed based on neurological signs, clinical symptoms, and neuroimaging tests, including computed tomographic or magnetic resonance imaging, in line with the World Health Organization criteria[17].

Statistical analysis

Continuous variables were compared using analysis of variance or the Kruskal-Wallis test according to distribution, and categorical variables were compared with the chi-square test.

Kaplan-Meier method was used to compute cumulative incidence of CVD and subgroup of CVD. Cox proportional hazard models were used with age as the time scale to estimate the hazard ratios (HRs) for incident CVD by cumulative TyG index, and were adjusted for baseline confounders, including sex, income (categories of high, intermediate, and low), educational level, drinking (yes or no), smoking (yes or no), diabetes, hypertension, lipid‐lowering medication, BMI, resting heart rate(RHR), HDL-C, LDL-C, UA, Hs-CRP. Missing covariates were imputed by multiple imputation using the fully conditional specification method SAS MI procedure. The results were consistent from analyses that excluded participants with missing covariates. The proportional hazard assumption was examined by Schoenfeld residuals.

To examine the robustness of our results, we performed several sensitivity analyses. First, we excluded events occurring in the first 2 years of follow-up to minimize potential reverse causation. Second, we excluded participants with diabetes or received treatment with lipid lowering medication and repeated analysis. Third, additional adjustment for TyG index at baseline. All analyses were done with SAS (version 9.4), at a two-tailed alpha level of 0.05.

Baseline characteristics of participants

A total of 44,087 eligible participants were included in present analysis, their mean age was 54.30±11.65 years, and 74.80% were men. The average cumulative TyG index was 54.12±5.13. To baseline characteristics of participants according to the quartile of cumulative TyG index are shown in Table 1. When compared to the Q1 group, participants in the other groups were more likely to be older, men, less well educated, more current smokers and drinkers, a higher prevalence of hypertension, diabetes, and lipid‐lowering medication, more likely to table antihypertensive agents and antidiabetic agents, had a high BMI, RHR, LDL-C, UA and Hs-CRP level, and a lower HDL-C level.

Association between cumulative TyG index and risk of CVD

After a mean follow-up of 6.52±1.14 years starting after the fourth examination, incident CVD, MI and stroke occurred in 2057, 395 and 1695, respectively. The Kaplan-Meier curve indicates a stepwise increase in the incidence of CVD across the patterns of cumulative TyG index(X²=223.71, P＜0.001). Table 2 reports the incidence rates of CVD and subtypes of CVD multivariable HR by categories of cumulative TyG index. Compared with those with Q1 group, risk of CVD was significantly higher in those with Q2 group (HR 1.25; 95% CI 1.08, 1.44), Q3 group (HR 1.22; 95% CI 1.05, 1.40), and Q4 group (HR 1.39; 1.21, 1.61). Similar results were obtained for the subgroup analysis (Table 3).

Time exposure duration of TyG index and risk of CVD

Figure 2b shows the Kaplan-Meier incidence rate stratified by the times of examinations with a higher TyG index. There was a progressively increasing risk of incidence with the times of examinations with a higher TyG index(P<0.001). After adjustment for potential confounders, compared with the unexposed group (0 years), risk of CVD was significantly higher in those with 2 years group (HR 1.29; 95% CI 1.15, 1.46), 4 years group (HR 1.25; 95% CI 1.09, 1.44), 6 years group (HR 1.21; 95% CI 1.04, 1.42), and 8 years group (HR 1.42; 95% CI 1.22, 1.66).

Sensitivity analysis

In the sensitivity analyses, the associations of cumulative TyG index with risk of incident CVD were not materially changed after excluding participants with CVD occurring within the first two years of the follow-up, or excluding participants who received treatment with lipid-lowering medications, or excluding participants with diabetes, or additional adjustment for TyG index at baseline(Table 4).

In this prospective cohort study of 44,087 Kailuan study, we found that an association between cumulative TyG index and the risk of CVD. In particular, higher exposure to cumulative TyG index was associated with CVD and subgroup of CVD in a period of mean 6.52 years. We also found that longer time of higher TyG index exposure could increase risk for CVD and subgroup. Additionally, this result was also validated in non-diabetes and not taking lipid-lowering medication populations.

Previous studies have found that participants with a higher TyG index were at a higher risk of developing CVD compared to low-level group[8-10]. However, in most studies, TyG index was based on single assessments, and ignoring the changes of TyG index over time, which would result in potential regression dilution bias and may affect the accuracy of the results. TyG index is calculated by TG and FBG, and these makers show dynamic changes in state. Therefore, the evaluation of the TyG index at baseline alone does not reflect the longitudinal association between the cumulative effect of TyG index and CVD risk over time. In the present study, we found that cumulative effect of TyG index had an increased risk of developing CVD. The risk of CVD development was highest in individuals with highest quartile group, with multivariate-adjusted HR of 1.39 (95% CI, 1.21-1.61). In addition, this risk was not attenuated by additional adjustment for baseline TyG index. The cumulative effect seems to be independent of- and better than the baseline TyG index in the pathogenesis of CVD. Likewise, the longest exposure time was associated with the highest risk of CVD.

Another important finding was derived from our subgroup analysis. Our findings indicate that cumulative TyG index seems to significantly increase the risk of developing MI and stroke, and the risk of cumulative TyG index developing in MI is slightly higher than that in stroke. Epidemiological survey showed that the prevalence of stroke patients are significantly more than patients with MI[18]. Although dyslipidemia and diabetes were observed to be risk factors for development of MI and stroke, these differences in the characteristics of disease itself create the potential for bias. Similarly, because of the limitations of case number, this may, in part, account for the did not reach statistical significance in sensitivity analysis after excluding participants with outcomes occurring within the first two years of the follow-up.

To the best of our knowledge, few cohort studies have explored TyG index by repeated measurements analysis. Wang et al. found that higher levels of TyG index were associated with an increased risk of future stroke and ischemic stroke by updated cumulative average exposure[19]. In the Rural Chinese Study of a large prospective cohort of 5,706 participants, the differences in TyG index between baseline and a subsequent examination was used to predict the risk of type 2 diabetes, and the results showed that the risk of incident diabetes was increased with the highest quartile of change in TyG index in normal-weight people[20]. Nevertheless, the relationship between cumulative exposure of TyG index and CVD has not been investigated in previous studies. The present findings imply that a substantial increase in TyG index is associated with a high risk of CVD, which highlights the importance of early controlling the glucose and lipids in clinical practice. Meanwhile, our findings offer a practical reference for clinical related to the application of guideline recommendations to primary prevention of CVD.

The increased risks of CVD and subgroup is possibly explained by persistent, low-degree inflammation, arterial stiffness and endothelial dysfunction caused by cumulative TyG index[21-23]. Previous studies have detected a positive association between arterial stiffness and TyG index as well as insulin resistance[24]. Continuous elevated of TyG index will lead to structural and functional changes in the arterial walls, resulting in further decrease of large arterial elasticity, and these changes could lead to CVD onset.

Our study has important implications for CVD prevention. For the general populations, maintaining a healthy level of TyG index within the desirable range and better control of cumulative TyG index is important for controlling the chronic diseases. For patients with diabetes and hyperlipidemia, motivating patients to adhere to glucose-lowering, and lipid-lowering medications and treatment monitoring for a long time for actively controlling FBG and TG levels. Strengths of the current study include the use of its prospective cohort design, large sample size, a long follow-up for CVD events and repeated measurements of multiple laboratory variables. However, our investigation has several limitations. First, was not directly collected and HOMA-IR could not be evaluated. In addition, HbA1C and 2h-oral glucose tolerance test were not measured but was estimated by fasting blood sample that might have overestimated or underestimated the actual prevalence of diabetes. Finally, this was an observational study, and causality cannot be demonstrated.

In the present study, we observed that cumulative TyG index was associated with increased risk of CVD. Hence, clinicians should consider the risk of incident CVD in people with abnormal FBG and TG and counsel them about metabolic fitness.

BMI: Body mass index; CI: Confidence interval; CVD: Cardiovascular disease; FBG: Fasting blood glucose; HR: Hazard ratio; Hs-CRP: High-sensitivity C-reactive protein; LDL-C: Low-density lipoprotein cholesterol; SD: Standard deviation; TG: Triglyceride; TyG: Triglyceride-glucose; UA: Uric acid.

Ethics approval and consent to participate

The study was performed according to the guidelines of the Helsinki Declaration and was approved by the Ethics Committee of Kailuan General Hospital (approval number: 2006-05). All participants were agreed to take part in the study and provided informed written consent.

Consent for publication

Not Applicable.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Competing interests

The authors declare no potential conflict of interest.

Funding

None

Authors’ contributions

Haozhe Cui and Liu Qian wrote the main manuscript text and conceived and designed the study. Haozhe Cui analyzed the data. Liu Qian carried out literature seach. Yuntao Wu and Liying Cao performed the manuscript review. All authors have read and approved the content of the manuscript.

Acknowledgments

The authors thank all the members of the Kailuan Study Team for their contributions and the participants who contributed their data. Hey, Liu, I love you.

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Table1. Baseline characteristics of participants by cumulative TyG index quartiles

	Q1 group	Q2 group	Q3 group	Q4 group	P
N	11022	11022	11021	11022	＜0.001
Age, years	49.93±10.70	52.78±11.43	56.25±11.48	58.23±11.21	＜0.001
Male, %	69.64	76.54	77.41	75.62	＜0.001
BMI, kg/m²	24.15±3.19	24.75±3.23	25.29±3.24	25.88±3.18	＜0.001
RHR, beats/min	71.73±9.73	72.81±10.54	73.78±10.57	75.14±10.69	＜0.001
HDL-C, mmol/L	1.43(1.21-1.69)	1.38(1.19-1.60)	1.32(1.11-1.55)	1.20(0.99-1.44)	＜0.001
LDL-C, mmol/L	2.24(1.68-2.84)	2.50(2.01-2.97)	2.50(2.00-3.05)	2.59(2.07-3.14)	＜0.001
UA, μmol/L	307.20±91.64	296.72±92.95	309.69±89.44	326.38±89.90	＜0.001
Hs-CRP, mg/dL	1.12(0.40-3.00)	0.90(0.20-2.20)	1.23(0.51-2.62)	1.60(0.83-3.00)	＜0.001
High income, %	753(23.14)	743(22.83)	842(25.88)	916(28.15)	＜0.001
High school or above, %	1064(28.89)	947(25.71)	865(23.49)	807(21.91)	＜0.001
Drinking, %	1629(21.16)	1772(23.02)	2039(26.49)	2257(29.32)	＜0.001
Smoking, %	3170(23.88)	3063(23.08)	3488(26.28)	3551(26.76)	＜0.001
Physical exercise, %	1056(17.17)	1335(21.70)	1815(29.50)	1946(31.63)	＜0.001
Diabetes, %	225(6.77)	496(14.93)	813(24.47)	1789(53.84)	＜0.001
Hypertension, %	2744(16.49)	4184(25.14)	4488(26.97)	5225(31.40)	＜0.001
Lipid‐lowering medication, %	245(16.20)	288(19.05)	415(27.45)	564(37.30)	＜0.001
TyG index₂₀₀₆	8.18±0.53	8.50±0.57	8.71±0.59	9.15±0.67	＜0.001
TyG index₂₀₀₈	8.17±0.51	8.52±0.51	8.72±0.54	9.24±0.69	＜0.001
TyG index₂₀₁₀	8.24±0.50	8.52±0.52	8.74±0.54	9.27±0.67	＜0.001
TyG index₂₀₁₂	8.29±0.53	8.52±0.55	8.74±0.60	9.22±0.71	＜0.001

Note: BMI body mass index, RHR resting heart rate, HDL high-density lipoprotein, LDL low-density lipoprotein, UA uric acid, Hs-CRP high-sensitivity C-reactive protein, TG triglyceride, FBG fasting blood glucose, TyG triglyceride glucose.

Table2. Association of cumulative TyG index with CVD

	Case	Cumulative incidence, %	Sex-adjusted	Multiple-adjusted
Quartiles
Q1	313	3.13	Ref.	Ref.
Q2	479	4.97	1.36(1.18-1.57)	1.25(1.08-1.44)
Q3	548	5.91	1.39(1.20-1.60)	1.22(1.05-1.40)
Q4	717	7.51	1.78(1.55-2.04)	1.39(1.21-1.61)
P for trend	＜0.001
Per SD	1.10(1.05-1.16)

Time exposure duration
0 year	832	4.22	Ref.	Ref.
2 years	433	6.03	1.45(1.29-1.63)	1.29(1.15-1.46)
4 years	285	6.06	1.52(1.33-1.74)	1.25(1.09-1.44)
6 years	230	6.24	1.55(1.34-1.80)	1.21(1.04-1.42)
8 years	277	8.01	1.94(1.69-2.22)	1.42(1.22-1.66)
P for trend	＜0.001

Note1: Multivariable model adjusted for sex, income, educational level, drinking, smoking, diabetes, hypertension, lipid‐lowering medication, BMI, RHR, HDL-C, LDL-C, UA, Hs-CRP.

Note2: Culumative TyG index SD=5.13

Table3. Association of cumulative TyG index with subgroup of CVD

	MI			Stroke
	Case	Incidence/ person-years	Multiple-adjusted	Case	Incidence/ person-years	Multiple-adjusted
Quartiles
Q1	55	0.50	Ref.	263	2.70	Ref.
Q2	98	0.92	1.49(1.05-2.10)	389	4.14	1.20(1.02-1.40)
Q3	98	0.95	1.25(0.89-1.78	457	5.01	1.19(1.02-1.40)
Q4	144	1.40	1.53(1.09-2.16)	586	6.26	1.35(1.16-1.58)
P for trend	＜0.001			＜0.001
Per SD	1.08(0.97-1.21)			1.10(1.05-1.16)

Time exposure duration
0 year	142	0.67	Ref.	702	3.61	Ref.
2 years	90	1.10	1.58(1.20-2.08)	353	5.11	1.24(1.08-1.41)
4 years	52	1.00	1.32(0.94-1.85)	238	5.17	1.23(1.05-1.43)
6 years	47	1.20	1.47(1.03-2.10)	184	5.07	1.14(0.96-1.35)
8 years	64	1.78	1.89(1.34-2.66)	218	6.40	1.31(1.11-1.56)
P for trend	＜0.001			＜0.001

Note1: Multivariable model adjusted for sex, income, educational level, drinking, smoking, diabetes, hypertension, lipid‐lowering medication, BMI, RHR, HDL-C, LDL-C, UA, Hs-CRP.

Table4. Association of cumulative TyG index with CVD-sensitivity analysis

	Analysis 1			Analysis 2			Analysis 3			Analysis 4
	CVD	MI	Stoke	CVD	MI	Stoke	CVD	MI	Stoke	CVD	MI	Stoke
Quartiles
Q1	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.
Q2	1.26(1.07-1.49)	1.49(0.99-2.23)	1.23(1.02-1.47)	1.29(1.11-1.50)	1.53(1.07-2.19)	1.22(1.03-1.43)	1.25(1.08-1.45)	1.44(1.02-2.03)	1.19(1.02-1.40)	1.20(1.04-1.40)	1.38(0.98-1.96)	1.16(0.99-1.36)
Q3	1.20(1.02-1.42)	1.19(0.79-1.80)	1.21(1.01-1.44)	1.27(1.09-1.47)	1.31(0.91-1.88)	1.21(1.03-1.42)	1.23(1.06-1.42)	1.18(0.83-1.68)	1.19(1.02-1.40)	1.14(0.99-1.33)	1.12(0.78-1.60)	1.14(0.94-1.34)
Q4	1.35(1.15-1.59)	1.34(0.89-2.02)	1.36(1.14-1.63)	1.43(1.23-1.66)	1.60(1.11-2.29)	1.33(1.13-1.57)	1.41(1.22-1.63)	1.45(1.02-2.05)	1.33(1.13-1.56)	1.25(1.06-1.46)	1.24(0.85-1.80)	1.24(1.04-1.47)

Time exposure duration
0 year	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	Ref.	-	-	-
2 years	1.28(1.12-1.47)	1.46(1.04-2.04)	1.26(1.09-1.45)	1.22(1.07-1.38)	1.51(1.13-2.01)	1.16(1.01-1.33)	1.26(1.11-1.42)	1.53(1.15-2.02)	1.21(1.06-1.38)	-	-	-
4 years	1.26(1.08-1.48)	1.22(0.81-1.85)	1.27(1.06-1.51)	1.23(1.06-1.43)	1.24(0.86-1.79)	1.23(1.01-1.45)	1.19(1.04-1.38)	1.25(0.88-1.77)	1.18(1.01-1.38)	-	-	-
6 years	1.24(1.04-1.48)	1.54(1.01-2.34)	1.18(0.96-1.43)	1.10(0.92-1.31)	1.32(0.88-1.97)	1.05(0.86-1.28)	1.17(0.99-1.37)	1.40(0.97-2.01)	1.10(0.92-1.31)	-	-	-
8 years	1.51(1.26-1.79)	2.08(1.39-3.10)	1.42(1.17-1.72)	1.42(1.20-1.69)	2.11(1.46-3.03)	1.29(1.06-1.57)	1.43(1.22-1.67)	1.86(1.31-2.64)	1.32(1.10-1.57)	-	-	-

Note1: Multivariable model adjusted for sex, income, educational level, drinking, smoking, diabetes, hypertension, lipid‐lowering medication, BMI, RHR, HDL-C, LDL-C, UA, Hs-CRP.

Note2: Analysis1 excluded participants events occurring in the first 2 years of follow-up; Analysis2 excluded participants with diabetes; Analysis3 excluded received treatment with lipid lowering medication; Analysis4 additional adjustment for TyG index at baseline.

No competing interests reported.

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Cumulative Triglyceride-glucose Index Is a Risk for CVD: A Prospective Cohort Study

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