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Hirohide Yokokawa
Juntendo University school of medicine
Corresponding Author
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Background: The impact of subcutaneous fat accumulation remains controversial. This study assessed the association between visceral or subcutaneous fat area (VFA and SFA, respectively) and diabetes mellitus (DM) among Japanese subjects.
Methods: This was a cross-sectional study involving 1,907 eligible participants (men, 1,050; women, 857) who participated in a voluntary health check-up conducted at Juntendo University Hospital from January 2017 to December 2018, in Tokyo, Japan. Associations between VFA or SFA quartiles and DM were identified using adjusted odds ratios (AORs) and 95% confidence intervals (CIs) with multivariable logistic regression analysis adjusted for confounders. Receiver operating characteristic (ROC) curve analysis was used to assess appropriate cut-off values of VFA or SFA.
Results: Multivariate analyses showed that Q4 (≥125 cm2) of VFA was significantly positively associated with DM compared to Q1 (<65 cm2) (AOR=1.94, 95% CI=1.02-3.71), whereas there was no association between SFA and DM in men. Among women, Q4 (≥85 cm2) of VFA was significantly positively associated with DM compared to Q1 (< 30 cm2) (Q4, AOR=6.15, 95% CI=1.65-22.99). Also, Q3 and Q4 (≥135 cm2) of SFA were significantly positively associated with DM compared to Q1 (<90 cm2) (Q3, AOR=5.64, 95% CI=1.21-26.25; Q4, AOR=7.81, 95% CI=1.71-35.65). The appropriate cut-off value of VFA in men was 101.5 cm2. Those of VFA and SFA in women were 72.5 cm2 and 165.3 cm2, respectively.
Conclusion: Our results suggest the importance of considering SFA as well as VFA, especially in women, for primary and secondary prevention of DM.
Keywords
Lifestyle-related disorder, Prevention, Epidemiology, Subcutaneous fat, Visceral fat, Diabetes mellitus, Metabolic syndrome
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CURRENT STATUS: Published
View the published article at Diabetology & Metabolic Syndrome.
Version (no preprint)
Posted 25 Feb, 2021
Review #2 received
Received 25 Feb, 2021
Editorial decision: Accept
On 25 Feb, 2021
Reviewer #2 agreed
On 21 Feb, 2021
Editor assigned
On 26 Jan, 2021
Reviewers invited
Invitations sent on 26 Jan, 2021
Reviewer #1 agreed
On 26 Jan, 2021
Review #1 received
Received 26 Jan, 2021
Submission checks complete
On 26 Jan, 2021
Editor invited
On 26 Jan, 2021
First submitted
On 26 Jan, 2021
This version was not preprinted
Version 2
Posted 01 Feb, 2021
No community comments so far
Review #2 received
Received 25 Feb, 2021
Editorial decision: Accept
On 25 Feb, 2021
Reviewer #2 agreed
On 21 Feb, 2021
Reviewers invited
Invitations sent on 26 Jan, 2021
Reviewer #1 agreed
On 26 Jan, 2021
Review #1 received
Received 26 Jan, 2021
Editor assigned
On 26 Jan, 2021
Submission checks complete
On 26 Jan, 2021
Editor invited
On 26 Jan, 2021
No comments provided
Editorial decision: Minor revision
On 18 Jan, 2021
Review #2 received
Received 14 Jan, 2021
Review #1 received
Received 25 Nov, 2020
Reviewer #2 agreed
On 20 Nov, 2020
Reviewer #1 agreed
On 18 Nov, 2020
Submission checks complete
On 18 Nov, 2020
Editor assigned
On 17 Nov, 2020
Reviewers invited
Invitations sent on 17 Nov, 2020
Editor invited
On 17 Nov, 2020
First submitted
On 16 Nov, 2020
Metrics
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HTML Views: ...
Subject Areas
Endocrinology & Metabolism
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Diabetology & Metabolic Syndrome.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Hirohide Yokokawa
Juntendo University school of medicine
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Diabetology & Metabolic Syndrome.
Version (no preprint)
Posted 25 Feb, 2021
Review #2 received
Received 25 Feb, 2021
Editorial decision: Accept
On 25 Feb, 2021
Reviewer #2 agreed
On 21 Feb, 2021
Editor assigned
On 26 Jan, 2021
Reviewers invited
Invitations sent on 26 Jan, 2021
Reviewer #1 agreed
On 26 Jan, 2021
Review #1 received
Received 26 Jan, 2021
Submission checks complete
On 26 Jan, 2021
Editor invited
On 26 Jan, 2021
First submitted
On 26 Jan, 2021
This version was not preprinted
Version 2
Posted 01 Feb, 2021
No community comments so far
Review #2 received
Received 25 Feb, 2021
Editorial decision: Accept
On 25 Feb, 2021
Reviewer #2 agreed
On 21 Feb, 2021
Reviewers invited
Invitations sent on 26 Jan, 2021
Reviewer #1 agreed
On 26 Jan, 2021
Review #1 received
Received 26 Jan, 2021
Editor assigned
On 26 Jan, 2021
Submission checks complete
On 26 Jan, 2021
Editor invited
On 26 Jan, 2021
No comments provided
Editorial decision: Minor revision
On 18 Jan, 2021
Review #2 received
Received 14 Jan, 2021
Review #1 received
Received 25 Nov, 2020
Reviewer #2 agreed
On 20 Nov, 2020
Reviewer #1 agreed
On 18 Nov, 2020
Submission checks complete
On 18 Nov, 2020
Editor assigned
On 17 Nov, 2020
Reviewers invited
Invitations sent on 17 Nov, 2020
Editor invited
On 17 Nov, 2020
First submitted
On 16 Nov, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Diabetology & Metabolic Syndrome.
Background: The impact of subcutaneous fat accumulation remains controversial. This study assessed the association between visceral or subcutaneous fat area (VFA and SFA, respectively) and diabetes mellitus (DM) among Japanese subjects.
Methods: This was a cross-sectional study involving 1,907 eligible participants (men, 1,050; women, 857) who participated in a voluntary health check-up conducted at Juntendo University Hospital from January 2017 to December 2018, in Tokyo, Japan. Associations between VFA or SFA quartiles and DM were identified using adjusted odds ratios (AORs) and 95% confidence intervals (CIs) with multivariable logistic regression analysis adjusted for confounders. Receiver operating characteristic (ROC) curve analysis was used to assess appropriate cut-off values of VFA or SFA.
Results: Multivariate analyses showed that Q4 (≥125 cm2) of VFA was significantly positively associated with DM compared to Q1 (<65 cm2) (AOR=1.94, 95% CI=1.02-3.71), whereas there was no association between SFA and DM in men. Among women, Q4 (≥85 cm2) of VFA was significantly positively associated with DM compared to Q1 (< 30 cm2) (Q4, AOR=6.15, 95% CI=1.65-22.99). Also, Q3 and Q4 (≥135 cm2) of SFA were significantly positively associated with DM compared to Q1 (<90 cm2) (Q3, AOR=5.64, 95% CI=1.21-26.25; Q4, AOR=7.81, 95% CI=1.71-35.65). The appropriate cut-off value of VFA in men was 101.5 cm2. Those of VFA and SFA in women were 72.5 cm2 and 165.3 cm2, respectively.
Conclusion: Our results suggest the importance of considering SFA as well as VFA, especially in women, for primary and secondary prevention of DM.
Figure 1
Figure 2
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