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Research Article
Bledar Kraja
University of Medicine Tirana
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Introduction: Erosive reflux esophagitis caused a large clinical spectrum of symptoms. Our aim was to assess the prevalence of extra-esophageal symptoms in individuals with and those without erosive esophagitis in Albania.
Methods: A case-control study was conducted at the Regional Hospital of Durres, the second main district in Albania, a transitional country in South Eastern Europe, including 248 patients with erosive esophagitis (aged 46.5±16.3 years) and 273 controls (aged 46.4±16.0 years; response rate: 70%) enrolled during the period January 2013 – June 2014. Both cases and controls underwent upper endoscopy. Information on socio-demographic characteristics and lifestyle factors was also collected. Binary logistic regression was used to assess the association of erosive esophagitis and extra-esophageal symptoms.
Results: Patients with erosive esophagitis had a higher prevalence of excessive alcohol consumption, smoking, sedentarity, non-Mediterranean diet and obesity compared to their control counterparts (9% vs. 5%, 70% vs. 49%, 31% vs. 17%, 61% vs. 49% and 22% vs. 9%, respectively). Upon adjustment for all socio-demographic characteristics and lifestyle/behavioral factors, there was evidence of a strong association of erosive esophagitis with chronic cough (OR=3.2, 95%CI=1.7-5.8), and even more so with laryngeal disorders (OR=4.4, 95%CI=2.6-7.5). In all models, the association of erosive esophagitis with any extra-esophageal symptoms was strong and mainly consistent with each of the symptoms separately (fully-adjusted model: OR=4.6, 95%CI=2.9-7.3).
Conclusion: Our findings indicate that the prevalence of extra-esophageal symptoms is higher among patients with erosive esophagitis in a transitional country characterized conventionally by employment of a Mediterranean diet.
Keywords
Albania, erosive reflux esophagitis, extra-esophageal symptoms, GERD.
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CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
Version 1
Posted 25 Nov, 2020
No community comments so far
Editorial decision: Major revision
On 05 Jan, 2021
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Received 17 Dec, 2020
Reviewers agreed
On 11 Dec, 2020
Reviewers invited
Invitations sent on 20 Nov, 2020
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On 20 Nov, 2020
Editor invited
On 20 Nov, 2020
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On 20 Nov, 2020
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On 18 Nov, 2020
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Subject Areas
Gastroenterology & Hepatology
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A new preprint design is coming!
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See the published version of this preprint at BMC Gastroenterology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Bledar Kraja
University of Medicine Tirana
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Gastroenterology.
Version 1
Posted 25 Nov, 2020
No community comments so far
Editorial decision: Major revision
On 05 Jan, 2021
Reviews received
Received 17 Dec, 2020
Reviewers agreed
On 11 Dec, 2020
Reviewers invited
Invitations sent on 20 Nov, 2020
Editor assigned
On 20 Nov, 2020
Editor invited
On 20 Nov, 2020
Submission checks complete
On 20 Nov, 2020
First submitted
On 18 Nov, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Gastroenterology.
Introduction: Erosive reflux esophagitis caused a large clinical spectrum of symptoms. Our aim was to assess the prevalence of extra-esophageal symptoms in individuals with and those without erosive esophagitis in Albania.
Methods: A case-control study was conducted at the Regional Hospital of Durres, the second main district in Albania, a transitional country in South Eastern Europe, including 248 patients with erosive esophagitis (aged 46.5±16.3 years) and 273 controls (aged 46.4±16.0 years; response rate: 70%) enrolled during the period January 2013 – June 2014. Both cases and controls underwent upper endoscopy. Information on socio-demographic characteristics and lifestyle factors was also collected. Binary logistic regression was used to assess the association of erosive esophagitis and extra-esophageal symptoms.
Results: Patients with erosive esophagitis had a higher prevalence of excessive alcohol consumption, smoking, sedentarity, non-Mediterranean diet and obesity compared to their control counterparts (9% vs. 5%, 70% vs. 49%, 31% vs. 17%, 61% vs. 49% and 22% vs. 9%, respectively). Upon adjustment for all socio-demographic characteristics and lifestyle/behavioral factors, there was evidence of a strong association of erosive esophagitis with chronic cough (OR=3.2, 95%CI=1.7-5.8), and even more so with laryngeal disorders (OR=4.4, 95%CI=2.6-7.5). In all models, the association of erosive esophagitis with any extra-esophageal symptoms was strong and mainly consistent with each of the symptoms separately (fully-adjusted model: OR=4.6, 95%CI=2.9-7.3).
Conclusion: Our findings indicate that the prevalence of extra-esophageal symptoms is higher among patients with erosive esophagitis in a transitional country characterized conventionally by employment of a Mediterranean diet.
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