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cheng wang
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Background: Blood pressure is an important and modifiable cardiovascular risk factor. Ambulatory blood pressure monitoring (ABPM) provides valuable prognostic information in patients with chronic kidney disease (CKD), yet little is known about the association of various types of BP measurements with target organ damage (TOD) in patients with primary glomerular disease. The goal of this study was to investigate whether ambulatory blood pressure is better associated with TOD than clinic blood pressure in patients with primary glomerular disease.
Methods: 1178 patients with primary glomerular disease were recruited in this cross-sectional study. TOD were assessed by the following 4 parameters: left ventricular mass index (LVMI or LVH, left ventricular hypertrophy), estimated glomerular filtration rate (eGFR<60ml/min/1.73m 2 ), albumin-to-creatinine ratio (ACR≥30mg/g) and carotid intima-media thickness (cIMT) or plaque. Receiver operating characteristic (ROC) curve and multivariate logistic regression analyses were used to evaluate the relationship between ambulatory or clinic systolic blood pressure (SBP) indexes and TOD.
Results: Among 1178 patients (mean age, 39 years,54% men), 116, 458, 1031 and 251 patients had LVH, eGFR < 60 ml/min/1.73m 2 , ACR≥30mg/g and cIMT≥0.9mm or plaque respectively. Area under ROC curves for TOD in ambulatory SBP, especially nighttime SBP, was greater than that in clinic SBP ( P <0.05). Multivariate logistic regression analyses showed that 24h SBP, daytime SBP and nighttime SBP were significantly associated with LVH, eGFR<60 ml/min/1.73m 2 and ACR≥30mg/g after adjustment for clinic SBP, while the association of clinic SBP was attenuated after further adjustment for nighttime SBP.
Conclusions: Ambulatory blood pressure, especially nighttime blood pressure, is superior to clinic blood pressure in estimating TOD in patients with primary glomerular disease.
Key Words: Ambulatory blood pressure, Clinic blood pressure, Target organ damage, Primary glomerular disease
Keywords
Ambulatory blood pressure, Clinic blood pressure, Target organ damage, Primary glomerular disease
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CURRENT STATUS: Published
View the published article at BMC Nephrology.
No community comments so far
Editorial decision: Minor revision
On 03 Aug, 2020
Review #2 received
Received 30 Jul, 2020
Reviewer #2 agreed
On 14 Jul, 2020
Editor assigned
On 13 Jul, 2020
Reviewers invited
Invitations sent on 13 Jul, 2020
Reviewer #1 agreed
On 13 Jul, 2020
Review #1 received
Received 13 Jul, 2020
Submission checks complete
On 12 Jul, 2020
Editor invited
On 12 Jul, 2020
Version 1
Posted 09 Jan, 2020
No comments provided
Editorial decision: Major revision
On 18 Jun, 2020
Review #2 received
Received 24 May, 2020
Reviewer #2 agreed
On 14 Apr, 2020
Review #1 received
Received 21 Mar, 2020
Reviewer #1 agreed
On 10 Mar, 2020
Reviewers invited
Invitations sent on 05 Feb, 2020
Editor assigned
On 16 Dec, 2019
Submission checks complete
On 15 Dec, 2019
Editor invited
On 15 Dec, 2019
First submitted
On 12 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Urology & Nephrology
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A new preprint design is coming!
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See the published version of this preprint at BMC Nephrology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
cheng wang
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Nephrology.
No community comments so far
Editorial decision: Minor revision
On 03 Aug, 2020
Review #2 received
Received 30 Jul, 2020
Reviewer #2 agreed
On 14 Jul, 2020
Editor assigned
On 13 Jul, 2020
Reviewers invited
Invitations sent on 13 Jul, 2020
Reviewer #1 agreed
On 13 Jul, 2020
Review #1 received
Received 13 Jul, 2020
Submission checks complete
On 12 Jul, 2020
Editor invited
On 12 Jul, 2020
Version 1
Posted 09 Jan, 2020
No comments provided
Editorial decision: Major revision
On 18 Jun, 2020
Review #2 received
Received 24 May, 2020
Reviewer #2 agreed
On 14 Apr, 2020
Review #1 received
Received 21 Mar, 2020
Reviewer #1 agreed
On 10 Mar, 2020
Reviewers invited
Invitations sent on 05 Feb, 2020
Editor assigned
On 16 Dec, 2019
Submission checks complete
On 15 Dec, 2019
Editor invited
On 15 Dec, 2019
First submitted
On 12 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Urology & Nephrology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Nephrology.
Background: Blood pressure is an important and modifiable cardiovascular risk factor. Ambulatory blood pressure monitoring (ABPM) provides valuable prognostic information in patients with chronic kidney disease (CKD), yet little is known about the association of various types of BP measurements with target organ damage (TOD) in patients with primary glomerular disease. The goal of this study was to investigate whether ambulatory blood pressure is better associated with TOD than clinic blood pressure in patients with primary glomerular disease.
Methods: 1178 patients with primary glomerular disease were recruited in this cross-sectional study. TOD were assessed by the following 4 parameters: left ventricular mass index (LVMI or LVH, left ventricular hypertrophy), estimated glomerular filtration rate (eGFR<60ml/min/1.73m 2 ), albumin-to-creatinine ratio (ACR≥30mg/g) and carotid intima-media thickness (cIMT) or plaque. Receiver operating characteristic (ROC) curve and multivariate logistic regression analyses were used to evaluate the relationship between ambulatory or clinic systolic blood pressure (SBP) indexes and TOD.
Results: Among 1178 patients (mean age, 39 years,54% men), 116, 458, 1031 and 251 patients had LVH, eGFR < 60 ml/min/1.73m 2 , ACR≥30mg/g and cIMT≥0.9mm or plaque respectively. Area under ROC curves for TOD in ambulatory SBP, especially nighttime SBP, was greater than that in clinic SBP ( P <0.05). Multivariate logistic regression analyses showed that 24h SBP, daytime SBP and nighttime SBP were significantly associated with LVH, eGFR<60 ml/min/1.73m 2 and ACR≥30mg/g after adjustment for clinic SBP, while the association of clinic SBP was attenuated after further adjustment for nighttime SBP.
Conclusions: Ambulatory blood pressure, especially nighttime blood pressure, is superior to clinic blood pressure in estimating TOD in patients with primary glomerular disease.
Key Words: Ambulatory blood pressure, Clinic blood pressure, Target organ damage, Primary glomerular disease
Figure 1
Figure 2
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