Purpose: Evaluate the associations of FTO (rs9939609), MC4R (rs17782313), MTMR9 (rs2293855), and the genetic score with atherogenic risk in Brazilian children.
Methods: This is a cross-sectional study conducted with 544 children aged 4 to 9 years old. We obtained sociodemographic and lifestyle data by questionnaires, and biological sample (DNA) through oral swab. The single nucleotide polymorphisms (SNP) FTO (rs9939609), MC4R (rs17782313), and MTMR9 (rs2293855) were identified by the system taqman SNP genotyping and evaluated the obesity-related genetic risk score. Blood samples were collected for the lipid profile analysis (serum total cholesterol, HDLc, LDL-c, triglycerides). The atherogenic indexes (Castelli I and II indexes, atherogenic coefficient - AC, lipoprotein combination index - LCI and plasma atherogenic index - AIP) were calculated. We compared the distributions of outcomes (lipid profile and atherogenic indexes) by genotype categories using multivariable linear regression.
Results: Children with AG/AA genotypes in the polymorphism MTMR9 (rs2293855), had lower HDL-c level and higher TC/HDL-c, LDL-c/HDL-c ratios, and AC. Those with one or more polymorphisms (FTO rs9939609, MC4R rs17782313, and MTMR9 rs2293855) in the genetic risk score had lower HDL-c and higher TC/HDL-c, AC, LCI, and AIP.
Conclusion: The risk allele (AG/AA) of the MTMR9 (rs2293855) and the higher obesity-related genetic risk score were positively associated with higher atherogenic risk in Brazilian children.