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Research article
Wei Sun
China-Japan Friendship Hospital
Corresponding Author
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Objective: We evaluated the safety and efficacy of intra-articular (IA) magnesium (Mg) for postoperative pain relief after arthroscopic knee surgery.
Methods. We searched PubMed, Embase, Medline, Cochrane library, and Web of Science to identify randomized controlled trials that compared postoperative pain outcomes with or without IA Mg after knee arthroscopy. The primary outcomes were pain intensity at rest and with movement at different postoperative time points and cumulative opioid consumption within 24 hours after surgery. Secondary outcomes included the time to first analgesic request and side effects.
Results. In total, 11 randomized controlled trials involving 677 subjects met the eligibility criteria. Pain scores at rest and with movement 2, 4, 12, and 24 h after surgery were significantly lower, doses of supplementary opioid consumption were smaller, and the time to first analgesic requirement was longer in the IA Mg group compared with the control group. No significant difference was detected regarding adverse reactions between the groups.
Conclusions. Administering IA Mg following arthroscopic knee surgery is effective for relieving postoperative pain intensity, reducing opioid consumption, and prolonging the time before analgesics are needed without increasing adverse reactions.
Protocol registration at Prospero: CRD42020156403.
Keywords
Intra-Articular, Magnesium, Arthroscopic knee surgery, Postoperative Pain, Meta-analysis
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CURRENT STATUS: Published
View the published article at Journal of Orthopaedic Surgery and Research.
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Editorial decision: Accept
On 23 Jan, 2021
Editor assigned
On 19 Jan, 2021
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On 19 Jan, 2021
Editor invited
On 19 Jan, 2021
Version (no preprint)
Posted 17 Jan, 2021
Review #1 received
Received 17 Jan, 2021
Editorial decision: Minor revision
On 17 Jan, 2021
Reviewer #3 agreed
On 15 Jan, 2021
Review #3 received
Received 15 Jan, 2021
Reviewer #2 agreed
On 13 Jan, 2021
Review #2 received
Received 13 Jan, 2021
Reviewers invited
Invitations sent on 12 Jan, 2021
Reviewer #1 agreed
On 12 Jan, 2021
Editor assigned
On 01 Jan, 2021
Submission checks complete
On 01 Jan, 2021
Editor invited
On 01 Jan, 2021
This version was not preprinted
Version 1
Posted 24 Nov, 2020
No comments provided
Editorial decision: Major revision
On 03 Dec, 2020
Reviewer #3 agreed
On 02 Dec, 2020
Review #2 received
Received 02 Dec, 2020
Review #3 received
Received 02 Dec, 2020
Review #1 received
Received 02 Dec, 2020
Reviewer #2 agreed
On 29 Nov, 2020
Reviewers invited
Invitations sent on 28 Nov, 2020
Reviewer #1 agreed
On 28 Nov, 2020
First submitted
On 18 Nov, 2020
Editor assigned
On 18 Nov, 2020
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On 18 Nov, 2020
Editor invited
On 18 Nov, 2020
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Journal of Orthopaedic Surgery and Research.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Wei Sun
China-Japan Friendship Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Journal of Orthopaedic Surgery and Research.
No community comments so far
Editorial decision: Accept
On 23 Jan, 2021
Editor assigned
On 19 Jan, 2021
Submission checks complete
On 19 Jan, 2021
Editor invited
On 19 Jan, 2021
Version (no preprint)
Posted 17 Jan, 2021
Review #1 received
Received 17 Jan, 2021
Editorial decision: Minor revision
On 17 Jan, 2021
Reviewer #3 agreed
On 15 Jan, 2021
Review #3 received
Received 15 Jan, 2021
Reviewer #2 agreed
On 13 Jan, 2021
Review #2 received
Received 13 Jan, 2021
Reviewers invited
Invitations sent on 12 Jan, 2021
Reviewer #1 agreed
On 12 Jan, 2021
Editor assigned
On 01 Jan, 2021
Submission checks complete
On 01 Jan, 2021
Editor invited
On 01 Jan, 2021
This version was not preprinted
Version 1
Posted 24 Nov, 2020
No comments provided
Editorial decision: Major revision
On 03 Dec, 2020
Reviewer #3 agreed
On 02 Dec, 2020
Review #2 received
Received 02 Dec, 2020
Review #3 received
Received 02 Dec, 2020
Review #1 received
Received 02 Dec, 2020
Reviewer #2 agreed
On 29 Nov, 2020
Reviewers invited
Invitations sent on 28 Nov, 2020
Reviewer #1 agreed
On 28 Nov, 2020
First submitted
On 18 Nov, 2020
Editor assigned
On 18 Nov, 2020
Submission checks complete
On 18 Nov, 2020
Editor invited
On 18 Nov, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Journal of Orthopaedic Surgery and Research.
Objective: We evaluated the safety and efficacy of intra-articular (IA) magnesium (Mg) for postoperative pain relief after arthroscopic knee surgery.
Methods. We searched PubMed, Embase, Medline, Cochrane library, and Web of Science to identify randomized controlled trials that compared postoperative pain outcomes with or without IA Mg after knee arthroscopy. The primary outcomes were pain intensity at rest and with movement at different postoperative time points and cumulative opioid consumption within 24 hours after surgery. Secondary outcomes included the time to first analgesic request and side effects.
Results. In total, 11 randomized controlled trials involving 677 subjects met the eligibility criteria. Pain scores at rest and with movement 2, 4, 12, and 24 h after surgery were significantly lower, doses of supplementary opioid consumption were smaller, and the time to first analgesic requirement was longer in the IA Mg group compared with the control group. No significant difference was detected regarding adverse reactions between the groups.
Conclusions. Administering IA Mg following arthroscopic knee surgery is effective for relieving postoperative pain intensity, reducing opioid consumption, and prolonging the time before analgesics are needed without increasing adverse reactions.
Protocol registration at Prospero: CRD42020156403.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
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