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Research article
Jiumei Cao
Ruijin Hospital, Shanghai jiaotong University School of Medicine
Corresponding Author
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Background: Sarcopenia and handgrip strength have been observed and correlated in association with hypertension among the old-age people. However, the results reported in different studies were inconsistent. In the current study, we conducted a systematic review and meta-analysis to reveal the significant association between sarcopenia, handgrip strength, and hypertension in older adults. Methods: PubMed, MEDLINE, Cochrane Library, and EMBASE databases were searched from inception to 15 November, 2019 to retrieve the original research studies that addressed the association between sarcopenia, handgrip strength, and hypertension. All the relevant data were retrieved, analyzed, and summarized. Results: 19 studies met the inclusion criteria and a total of 21301 participants were included in the meta-analysis. Eight eligible studies have reported the odd ratios (ORs) of hypertension and the ORs ranged from 0.41 to 4.38. When pooled the ORs together, the summarized ORs was 1.29 95% confidence interval (CI) =1.00-1.67. The summarized ORs for the Asian group 1.50 (95% CI=1.35-1.67) was significantly higher than that of Caucasian group 1.08 (95% CI=0.39-2.97). Eleven studies have provided the data on association between handgrip strength and hypertension. The overall ORs and 95% CI was 0.99 (95% CI=0.80-1.23), showing no significant association. Conclusion: Sarcopenia was associated with hypertension, but no correlation was found between handgrip strength and hypertension in older adults.
Keywords
Sarcopenia, handgrip strength, hypertension, older adults, meta-analysis
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CURRENT STATUS: Published
View the published article at BMC Geriatrics.
Version 2
Posted 30 Mar, 2020
No community comments so far
Editorial decision: Major revision
On 03 Jun, 2020
Review #2 received
Received 23 May, 2020
Review #3 received
Received 22 May, 2020
Reviewer #3 agreed
On 05 May, 2020
Reviewer #2 agreed
On 04 May, 2020
Review #1 received
Received 30 Apr, 2020
Reviewers invited
Invitations sent on 29 Apr, 2020
Reviewer #1 agreed
On 29 Apr, 2020
Editor assigned
On 26 Mar, 2020
Submission checks complete
On 25 Mar, 2020
Editor invited
On 25 Mar, 2020
No comments provided
Editorial decision: Major revision
On 24 Feb, 2020
Review #3 received
Received 07 Feb, 2020
Review #1 received
Received 03 Feb, 2020
Reviewer #3 agreed
On 24 Jan, 2020
Reviewer #2 agreed
On 22 Jan, 2020
Review #2 received
Received 22 Jan, 2020
Reviewer #1 agreed
On 20 Jan, 2020
Editor assigned
On 17 Jan, 2020
Reviewers invited
Invitations sent on 17 Jan, 2020
Submission checks complete
On 10 Jan, 2020
Editor invited
On 09 Jan, 2020
First submitted
On 03 Jan, 2020
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Subject Areas
Geriatrics & Gerontology
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A new preprint design is coming!
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See the published version of this preprint at BMC Geriatrics.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Jiumei Cao
Ruijin Hospital, Shanghai jiaotong University School of Medicine
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Geriatrics.
Version 2
Posted 30 Mar, 2020
No community comments so far
Editorial decision: Major revision
On 03 Jun, 2020
Review #2 received
Received 23 May, 2020
Review #3 received
Received 22 May, 2020
Reviewer #3 agreed
On 05 May, 2020
Reviewer #2 agreed
On 04 May, 2020
Review #1 received
Received 30 Apr, 2020
Reviewers invited
Invitations sent on 29 Apr, 2020
Reviewer #1 agreed
On 29 Apr, 2020
Editor assigned
On 26 Mar, 2020
Submission checks complete
On 25 Mar, 2020
Editor invited
On 25 Mar, 2020
No comments provided
Editorial decision: Major revision
On 24 Feb, 2020
Review #3 received
Received 07 Feb, 2020
Review #1 received
Received 03 Feb, 2020
Reviewer #3 agreed
On 24 Jan, 2020
Reviewer #2 agreed
On 22 Jan, 2020
Review #2 received
Received 22 Jan, 2020
Reviewer #1 agreed
On 20 Jan, 2020
Editor assigned
On 17 Jan, 2020
Reviewers invited
Invitations sent on 17 Jan, 2020
Submission checks complete
On 10 Jan, 2020
Editor invited
On 09 Jan, 2020
First submitted
On 03 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Geriatrics & Gerontology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Geriatrics.
Background: Sarcopenia and handgrip strength have been observed and correlated in association with hypertension among the old-age people. However, the results reported in different studies were inconsistent. In the current study, we conducted a systematic review and meta-analysis to reveal the significant association between sarcopenia, handgrip strength, and hypertension in older adults. Methods: PubMed, MEDLINE, Cochrane Library, and EMBASE databases were searched from inception to 15 November, 2019 to retrieve the original research studies that addressed the association between sarcopenia, handgrip strength, and hypertension. All the relevant data were retrieved, analyzed, and summarized. Results: 19 studies met the inclusion criteria and a total of 21301 participants were included in the meta-analysis. Eight eligible studies have reported the odd ratios (ORs) of hypertension and the ORs ranged from 0.41 to 4.38. When pooled the ORs together, the summarized ORs was 1.29 95% confidence interval (CI) =1.00-1.67. The summarized ORs for the Asian group 1.50 (95% CI=1.35-1.67) was significantly higher than that of Caucasian group 1.08 (95% CI=0.39-2.97). Eleven studies have provided the data on association between handgrip strength and hypertension. The overall ORs and 95% CI was 0.99 (95% CI=0.80-1.23), showing no significant association. Conclusion: Sarcopenia was associated with hypertension, but no correlation was found between handgrip strength and hypertension in older adults.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
This is a list of supplementary files associated with this preprint. Click to download.
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