Commitment to protective measures during COVID-19 pandemic in Syria: a nationwide cross-sectional study.

Severe acute respiratory syndrome coronavirus 2 continues to impose itself on all populations of the world. Given the slow pace of vaccination in the developing world and the absence of effective treatments, adherence to precautionary infection control measures remains the best way to prevent the COVID-19 pandemic from spiraling out of control. In this study, we aim to evaluate the extent to which the Syrian population adheres to these measures and analyze the relationship between demographic variables and adherence.

and gloves, and avoidance of handshaking and face-touching), measure perceived risk regarding COVID-19, and study the correlation between commitment and some demographic variables.

Methods:
Study design, setting, and participants: A nationwide cross-sectional study was performed between January 17 to March 17, 2021. Data was collected using a structured self-administered questionnaire which was distributed to a nationally representative sample of Syrian people. The questionnaire, based on a previous study, was modi ed to be suitable for Syrian society (15)(16)(17). It was then piloted on a sample of 15 people to ensure clarity, and adjustments were made based on their feedback. Chain-referral and convenience sampling methods were employed by distributing the questionnaire in two formats: electronically as a Google Form survey via social media and messaging platforms (Facebook, Whatsapp, Twitter), and physically as hard copies to patients, their companions, and workers in public hospitals in each of Damascus, Aleppo, Homs, Tartous, Hama, and Sweida governorates. The sample size was calculated using OpenEpi online software available at "https://www.openepi.com/SampleSize/SSPropor.htm". According to data from the United Nations, the estimated population of Syria in 2019 was about 18 million (18); based on this gure, the sample required to represent the total population was calculated to be 7336, with a con dence level of 95% and a con dence interval of 1.14.
Inclusion criteria were that the person is: (1) 18 years old or above, (2) literate, (3) a Syrian citizen living in Syria, and (4) willing to complete the questionnaire. Of the 8083 participants who responded to the questionnaire, 551 were excluded for not meeting the inclusion criteria (17 withdrew their consent to participate, 543 were not Syrians or lived outside of Syria), yielding a nal sample size of 7,531 participants.

Measures:
The questionnaire consisted of 32 questions divided into 3 sections: 1. Socio-demographic characteristics : cancellation or postponement, self-isolation, cleaning or disinfecting touched items, carrying sanitizing hand-gel, reduced face-touching, healthy diet, avoiding people who have cold or u-like symptoms, using tissues when sneezing or coughing, and washing hands with soap and water.
Statistical analysis: Data from the hard copy questionnaires were entered manually by the investigators to the original Google Forms online questionnaire that was used to collect online data, after which it was exported to a Microsoft Excel spreadsheet. The raw data was then encoded in Excel to make it compatible with the statistics software. A 13 point scale was used to measure the level of commitment to IPC measures. Each individual measure was given one point, then each participant was categorized into one of three categories based on how many protective measures he/she applied: 1-Low commitment (0 -3 protective measures), 2-Moderate commitment (4 -8 protective measures) and 3-High commitment (9 -12 protective measures). We used Statistical Package for Social Sciences version 25.0 ( SPSS Inc., Chicago, IL, United States) to analyze the data. Categorical variables were reported as frequencies and percentages. Pearson's chi-square test was used to study the associations between categorical groups. A p-value < 0.05 was considered statistically signi cant.

Ethical considerations:
The study protocol was approved by the respective Research Ethics Committee at each of Damascus, Aleppo, Tartous, and Syrian Private Universities, and the ethics committees of each hospital from which data was collected. Informed consent was obtained from every participant prior to participation.
Participants with post-graduate education (80.6%, χ 2 = 640.976, p-value <0.0001) and students with full time jobs (77.1%, χ 2 = 129.431, p-value <0.0001) were the most committed to preventive measures. (Table  5) Our results revealed that people who believe that COVID-19 poses a major risk to Syrian society were more committed to IPC measures, with 77.4% being highly committed compared to 59.5% from the 'minor risk' group and 43.0% from the 'no risk at all' group. Similarly, those who believe that COVID-19 poses a major risk to them personally were more committed to preventive measures, as (79.5%) of them were in the high commitment category. (Table 6) Discussion: The COVID-19 pandemic has signi cantly impacted humanity and forced governments across the world to adopt extensive infection prevention and control measures with varying degrees of severity (19). Syria is a low-income country that has been ravaged by civil war for over a decade, diminishing the ability to adequately respond to the pandemic and impose meaningful quarantines. As such, results of measures adopted by other countries and regions cannot be relied upon to predict the course of the pandemic in Syria, and the extraordinary di culties facing the country and the realities on the ground must be taken into account when uniquely assessing the situation in Syria. The e ciency and impact of infection prevention and control (IPC) measures can be optimized by obtaining insights into the population's current commitment to such measures. To the best of our knowledge, this is the rst nationally representative study to offer insights into people's adherence to preventive measures during the COVID-19 pandemic in Syria. Our ndings revealed that 70.2% of the population claim to adhere to most of the preventive measures asked about in the questionnaire. This level of adherence is similar to that found in a Belgian study, and better than that from an Ethiopian study (20,21). The majority of our sample were young, and the age distribution of our population was generally consistent with the demographic data reported by the Central Bureau of Statistics (CBS), Damascus, Syria (22). According to the latest CBS report, 40% of the Syrian population were below 24 years old, and 25.5% were 25-44 years old (compared to 41.5% and 31%, respectively, of our study population) (22). The importance of face masks in reducing the spread of the virus is supported by numerous studies (23, 24). One study suggests that complete eradication of the disease can be achieved if 80% of the population uses face masks effectively (25). The vast majority of our participants (87.3%) were committed to wearing face masks in public spaces. This proportion is predictably lower than those from studies in China (98.0%) and Hong Kong (98.8%), where mask-wearing has been ingrained in the culture for decades, but considerably higher than in studies from Northwest Ethiopia (32.42%), Ethiopia (13.9%), Saudi Arabia (56.4%), and the United Kingdom (3.1%) (15,21,(26)(27)(28).
Low income and unemployment were correlated with lower adherence to IPC measures, while higher income and gainful employment was correlated with higher adherence; only 55% of low income responders were highly committed to IPC measures, compared to 76.6% of those with good nancial status. This may owe to the high cost of commitment to protective measures, which is prohibitively expensive for a signi cant proportion of the Syrian population. The Syrian pound has lost 35% of its value against the US dollar in the last year alone (14), and the percentage of the population living in poverty is 90% and rising (29). While screening tests and social distancing might be considered costeffective elsewhere in the world, this is not the case for the Syrian population (PCR screens cost $50 each and are not subsidized). Infection control measures such as sweeping lockdowns have only recently affected most of the world's economies, whereas the Syrian economy, already suffering from a decade of war and crippling sanctions, has been devastated by lockdowns and other pandemic-related economic pressures. As such, Syria's population and healthcare system are in desperate need of international support in the form of nancial grants and donations of personal protective equipment, drugs, medical supplies, and vaccines. Income and employment-related results are in line with studies from China and Ethiopia, but do not align with those of a study from Saudi Arabia, likely due to vastly different socioeconomic dynamics (15,26,28).
UNICEF reported that after a decade of war in Syria, more than half of children continue to be deprived of education (30). The enormous scale of the education crisis is extremely worrying, as it threatens not only the future of an entire generation of children and the country as a whole, but also the important role of schools as conduits for health literacy and education about diseases and the importance of infection control. Our study revealed an important correlation between education and adherence to IPC measures, with commitment increasing signi cantly as the level of education increases. On one end of the spectrum, only 35.2% of uneducated participants adhere to protective measures, compared to 80.6% of participants with postgraduate education on the other end. These ndings are consistent with studies from China, Ethiopia, and Germany (16, 26, 28).
Numerous studies have shown that risk perception can be considered a determinant of individual behavior during a disease outbreak (31-33). The more risk perceived, the more likely people are to adhere to preventive measures. Some studies go even further and suggest that it is important to differentiate between the 'experiential' and 'affective' components of risk perception (34,35). Earlier research demonstrated that experiential risk perception, "the gut feeling of being vulnerable to risk", was positively associated with applying personal protective actions, such as vaccination and sun protection (36, 37). Our study seems to support this assumption, and other studies in Italy, Northwest Ethiopia reported the same observation (21, 38).
Several previous studies showed that the level of knowledge correlates directly with adherence to preventive measures (28, 39). Ideally, the public should be well-informed by reliable sources of information. Unfortunately, our participants' reliance on untrusted sources on social media is part of a global trend in which misinformation is rampant and pervasive. Social media tends to be the most expedient means of obtaining information for many people, and studies have shown that social media is a fertile and target-rich environment for spreading misinformation and conspiracy theories that negatively affect the quality of the public's knowledge (40)(41)(42). Since it is impossible to fully control what is published on social media, local and global health authorities must enhance their presence on these platforms and use engaging content and effective methods to spread awareness and accurate information. Studying the public's perception and behavior toward COVID-19 provides valuable insight which can help policymakers and healthcare providers to address the knowledge gaps that negatively affect people's perception and behavior, thereby improving the national response to this pandemic. We encourage all concerned institutions to invest the time, resources, and expertise necessary to successfully and signi cantly leverage social media platforms to drive public health education and COVID-19 awareness campaigns. The rebuilding and rehabilitation of schools must be prioritized, and infection control measures incorporated into the curriculum. Special accommodations should be made for lowincome people and families, in the form of distributing infection control kits (composed of a reusable face mask and hand sanitizer) and securing their income when proven to be sick to encourage them to self-quarantine.

Conclusion:
Despite the high level of commitment to infection prevention and control (IPC) measures demonstrated by the participants in our study, it is necessary to stress the importance of continuing this commitment throughout the pandemic. It is recommended that local and international health authorities carry out continuous awareness campaigns with the aim of reminding the population of the importance of consistently applying IPC measures. Moreover, the population should be educated about how to identify and avoid misinformation on social media and to rely on reliable sources of information. Because of the economic and humanitarian situation in war-torn Syria, it is necessary for all concerned bodies and organizations to take serious action and provide appropriate assistance to the healthcare system to help contain this pandemic.

Limitations:
This study is subject to some limitations. First, as a cross-sectional study it may not be able to determine causation, therefore more longitudinal studies are recommended. Second, distributing the questionnaire online only will lead to selection bias, as most people with internet access tend to be younger and wealthier. To minimize this bias we distributed the questionnaire both online and as hard copies. Third, many questions were subject to recall bias. Finally, the economic status question was subjective since the value of the Syrian pound is not stable and the exchange rate continues to uctuate. This continues to affect the purchasing power of the local currency, with many families whose income was once adequate falling below the poverty line.

Declarations:
Ethics approval and consent to participate: The study protocol was approved by the Research Ethics Committee in each of Damascus, Aleppo, Tartous, and Syrian Private Universities, and the ethical committees in the concerned hospitals. Informed consent was obtained from every participant prior to participation.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Availability of data and materials:
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Competing interest:
The authors declare that they have no competing interests Funding: This project did not receive any funding from any agencies in the public, commercial, or non-pro t sectors.