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Research Article
Yajun Lian
First Affiliated Hospital of Zhengzhou University
Corresponding Author
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We aimed to investigate the association between thyroid hormones and functional outcome in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. 137 consecutive inpatients (2016-2019) were registered prospectively and followed up for 12 months. 96 eligible patients were included in the study. The modified Rankin scale (mRS) score of 3-6 was defined as poor functional outcome. Logistic regression analysis was performed. The patients were classified into 3 subgroups based on their free triiodothyronine (fT3) levels, and the subgroup differences were analyzed by parametric or nonparametric tests as appropriate. We found that the fT3 value upon admission was correlated with functional outcome (P=0.004), and this effect remained significant after adjustment for age, gender, tumor presence and consciousness declination. Patients in the low-fT3 subgroup had a higher disease severity during the acute phase, represented by greater maximum mRS scores during hospitalization (P=0.011) and higher percentages of intense care unit admission (p<0.001). In Conclusion,the relatively low fT3 value is associated with a poor functional outcome. Besides, patients with relatively low fT3 tend to have a higher disease severity during the acute phase. Our preliminary data suggest that the fT3 value might serve as a potential predictor of functional outcome in patients with anti-NMDAR encephalitis.
Keywords
Anti-N-methyl-D-aspartate receptor encephalitis, thyroid hormone, free triiodothyronine, functional outcome
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View the published article at Scientific Reports.
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See the published version of this preprint at Scientific Reports.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Yajun Lian
First Affiliated Hospital of Zhengzhou University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Scientific Reports.
Version 1
Posted 01 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 04 Feb, 2021
Reviews received
Received 01 Feb, 2021
Reviewers agreed
On 20 Jan, 2021
Reviewers agreed
On 13 Jan, 2021
Reviewers invited
Invitations sent on 07 Jan, 2021
Editor assigned
On 07 Jan, 2021
Editor invited
On 25 Nov, 2020
Submission checks complete
On 25 Nov, 2020
First submitted
On 23 Nov, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Scientific Reports.
We aimed to investigate the association between thyroid hormones and functional outcome in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. 137 consecutive inpatients (2016-2019) were registered prospectively and followed up for 12 months. 96 eligible patients were included in the study. The modified Rankin scale (mRS) score of 3-6 was defined as poor functional outcome. Logistic regression analysis was performed. The patients were classified into 3 subgroups based on their free triiodothyronine (fT3) levels, and the subgroup differences were analyzed by parametric or nonparametric tests as appropriate. We found that the fT3 value upon admission was correlated with functional outcome (P=0.004), and this effect remained significant after adjustment for age, gender, tumor presence and consciousness declination. Patients in the low-fT3 subgroup had a higher disease severity during the acute phase, represented by greater maximum mRS scores during hospitalization (P=0.011) and higher percentages of intense care unit admission (p<0.001). In Conclusion,the relatively low fT3 value is associated with a poor functional outcome. Besides, patients with relatively low fT3 tend to have a higher disease severity during the acute phase. Our preliminary data suggest that the fT3 value might serve as a potential predictor of functional outcome in patients with anti-NMDAR encephalitis.
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