Objectives
The purpose of this study was to evaluate the relationships among tobacco smoking, drinking alcohol, obesity and sialolithiasis in a Korean population.
Methods
The Korean National Health Insurance Service-Health Screening Cohort, which includes patients ≥ 40 years old, was assessed from 2002 to 2013. 947 sialolithiasis participants were matched with 3,788 control subjects at a ratio of 1:4 with respect to age group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed participants’ previous histories of smoking (current or past smokers compared to nonsmokers) and alcohol consumption (≥ 1 time per week compared to < 1 time per week) in the sialolithiasis and control groups. Obesity was measured using body mass index (BMI, kg/m2), which was categorized as < 18.5 (underweight), ≥ 18.5 and < 23 (normal), ≥ 23 and < 25 (overweight), ≥ 25 and < 30 (obese I), and ≥ 30 (obese II). Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression analyses.
Results
The rate of smoking was higher in the sialolithiasis group (32.4% [307/947]) than in the control group (29.1% [1,103/3,788], P = 0.047). The adjusted OR of smoking for sialolithiasis was 1.31 (95% CI = 1.08-1.59, P = 0.006). Alcohol consumption and obesity were not statistically significantly related to sialolithiasis.
Conclusion
The odds of smoking were increased in sialolithiasis patients compared with the control subjects in ≥ 40 years old population.

Figure 1
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On 07 Apr, 2020
On 07 Apr, 2020
On 30 Mar, 2020
On 23 Mar, 2020
Received 23 Mar, 2020
On 23 Mar, 2020
Received 23 Mar, 2020
On 22 Mar, 2020
Invitations sent on 22 Mar, 2020
On 21 Mar, 2020
On 21 Mar, 2020
Posted 14 Jan, 2020
On 26 Feb, 2020
Received 18 Feb, 2020
On 11 Feb, 2020
Received 23 Sep, 2019
Invitations sent on 05 Sep, 2019
On 05 Sep, 2019
On 28 Jun, 2019
On 27 Jun, 2019
On 27 Jun, 2019
On 26 Jun, 2019
On 07 Apr, 2020
On 07 Apr, 2020
On 30 Mar, 2020
On 23 Mar, 2020
Received 23 Mar, 2020
On 23 Mar, 2020
Received 23 Mar, 2020
On 22 Mar, 2020
Invitations sent on 22 Mar, 2020
On 21 Mar, 2020
On 21 Mar, 2020
Posted 14 Jan, 2020
On 26 Feb, 2020
Received 18 Feb, 2020
On 11 Feb, 2020
Received 23 Sep, 2019
Invitations sent on 05 Sep, 2019
On 05 Sep, 2019
On 28 Jun, 2019
On 27 Jun, 2019
On 27 Jun, 2019
On 26 Jun, 2019
Objectives
The purpose of this study was to evaluate the relationships among tobacco smoking, drinking alcohol, obesity and sialolithiasis in a Korean population.
Methods
The Korean National Health Insurance Service-Health Screening Cohort, which includes patients ≥ 40 years old, was assessed from 2002 to 2013. 947 sialolithiasis participants were matched with 3,788 control subjects at a ratio of 1:4 with respect to age group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed participants’ previous histories of smoking (current or past smokers compared to nonsmokers) and alcohol consumption (≥ 1 time per week compared to < 1 time per week) in the sialolithiasis and control groups. Obesity was measured using body mass index (BMI, kg/m2), which was categorized as < 18.5 (underweight), ≥ 18.5 and < 23 (normal), ≥ 23 and < 25 (overweight), ≥ 25 and < 30 (obese I), and ≥ 30 (obese II). Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression analyses.
Results
The rate of smoking was higher in the sialolithiasis group (32.4% [307/947]) than in the control group (29.1% [1,103/3,788], P = 0.047). The adjusted OR of smoking for sialolithiasis was 1.31 (95% CI = 1.08-1.59, P = 0.006). Alcohol consumption and obesity were not statistically significantly related to sialolithiasis.
Conclusion
The odds of smoking were increased in sialolithiasis patients compared with the control subjects in ≥ 40 years old population.

Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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