Investigation on antibody level of umbilical cord blood measles in 2017 in ankang city, Shaanxi province, China


 Background Through the examination and analysis of the level of the antibody against the umbilical cord blood measles in maternal newborn in ankang city, to explore prevention and control measures and strategies of measles. Methods Using indirect enzyme-linked immunoadsorption testto test the level of Measles IgG antibody in 848 randomly collected neonatal umbilical cord blood samples,and Using descriptive epidemiological methods,Enter relevant data into Microsoft Excel to establish a database,Statistical analysis using SPSS. Results The positive rate of measles IgG antibody was 84.43 % in 848 neonatal umbilical cord blood samples in Ankang City.There is no statistical difference in the positive rate of neonatal umbilical cord blood measles IgG antibody in different age groups（P>0.05）,However, the positive rate of neonatal umbilical cord blood measles IgG showed a decreasing trend with the increase of maternal age;Maternal and newborn umbilical cord blood measles IgG antibody positive rate and different forms of residence, different maternal births has nothing to do with,but it is related to the county and district where it is located and the vaccination service model.In the counties where the quality of vaccination services is good, and in the areas where the township vaccination service model is implemented, the positive rate of maternal newborn umbilical cord blood measles IgG antibodies is higher, and the difference is statistically significant(P & lt; 0.05). Conclusions Vaccination of measles ingredients before pregnancy in women of childbearing age can not only increase the level of measles antibodies in people of childbearing age, but also increase the level of measles antibodies in infants born in August before the birth of Mazhenyimiao, thus effectively reducing the incidence of measles in children over 15 years of age and within the age of 8 months.It is of great significance to strengthen the standardized administration of vaccination, adjust the vaccination service model, and vigorously promote the centralized vaccination service model in townships and towns to reduce the incidence of measles.

vaccination service model, and vigorously promote the centralized vaccination service model in townships and towns to reduce the incidence of measles.

Background
Measles is one of the most common acute respiratory infections in children and it is very contagious.Since 1965, the incidence of measles decreased significantly after the introduction of live measles vaccine in China.In 2005, the World Health Organization(WHO) Western Pacific Region(WPR) Committee passed a resolution to eliminate measles by 2012 [1] As required by the Ministry of Health's National Action Plan for the Elimination of At the same time, it has done a good job in routine immunization, disease surveillance and epidemic treatment. The incidence of measles has dropped significantly.Epidemiological studies have shown that the incidence of measles in the city's large age group has shown an increasing trend [3] This phenomenon has also appeared in the process of eliminating measles in some developed countries [4] By studying the level of antibodies against umbilical cord blood measles in 848 newborns, this paper analyzes the positive rate of antibodies against measles in newborns, and discusses the relationship between factors such as maternal age, regions, vaccination service forms, and distribution between urban and rural areas and the incidence of measles.t will provide scientific basis for making prevention and control strategies of measles and effectively reducing the incidence of measles.

Methods
1 Research subjects From April to May 2017, 848 newborn umbilical cord blood specimens were randomly collected at the maternity hospitals in ten counties in Ankang City. The minimum age of maternity was 16 years old and the maximum was 45 years old.
2 Detection methods The basic information of 848 mothers was obtained through questionnaires;The umbilical cord blood of each newborn was collected 3-5 ML, and the serum was separated within 24 hours and preserved at -20 °C.The measles IgG antibody was quantitatively detected using an Elisa kit provided by the German Virun/Serun Medical

Discussion
The study confirmed that the detection results of neonatal umbilical cord blood measles IgG antibody and maternal venous blood detection results are basically the same [6] , The level of Measles antibody can reflect the level of Measles antibody.According to relevant research reports, the positive rate of measles antibodies is more than 90% to effectively block measles transmission.The results of this study showed that the positive rate of IgG antibodies for neonatal umbilical cord blood in Ankang was 84.43%, indicating that at least 15% of pregnant women are still at risk of contracting measles virus.The positive rate of neonatal umbilical cord blood measles IgG antibody was not statistically significant in all age groups, but the positive rate of neonatal umbilical cord blood measles IgG antibody showed a decreasing trend with the increase of maternal age, which is consistent with the domestic research results [7] .Epidemiological studies have found that measles incidence in Ankang has appeared in recent years. The "bidirectional shift" in the incidence of August age and ≥ 15 years of age, which is the transfer of measles to older and unvaccinated populations, is closely related to the decline of adult measles antibodies [8][9][10] .Vaccination of measles ingredients before pregnancy in women of childbearing age can not only increase the level of measles antibodies in people of childbearing age, but also increase the level of measles antibodies in infants born in August before the birth of Mazhenyimiao, thus effectively reducing the incidence of measles in children over 15 years of age and within the age of 8. Achieving the effect of "one generation immunity, two generations benefit" is of great significance for blocking "biphase shift" [11] .
The positive rate of female neonatal umbilical cord blood measles IgG had nothing to do with different residence forms and maternal birth times, but it was related to different IgG antibody is higher than that of village inoculation in the area where the township concentrated inoculation service is implemented.Although there was no significant difference in reported vaccination rate between different vaccination service modes, the quality of vaccination outpatient service was significantly higher than that of village vaccination sites [12] .

Conclusions
Therefore, we will strengthen the standardized administration of vaccination, adjust the

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Availability of data and material:
The data and materials in this article are available.
In order to protect the privacy of participants, the original data set in our study cannot be shared.

Competing interests:
There is no Competing interests in this article.
Funding: This article has no funding.

Authors' contributions:
The first author is Wan Chunge, who has made major contributions to this article.She have made substantial contributions to the conception, design of the work, the acquisition, analysis, interpretation of data and the creation of new software used in the work. Dai Xiaoqiang, Luo Yanqi, Chen Lei and LIU Bin have made a few contributions to this article.