See the published version of this preprint at Women's Midlife Health.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Rosanne Woods
California University of Pennsylvania
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0717-0702
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The purpose of this study was to examine the association of lean body mass (LBM) to the development of vasomotor symptoms (VMS) as women transition through menopause.
Methods: This study is a secondary use of data available for public use from follow up visits six through 10 for participants in the Study of Women’s Health Across the Nation. The study examined 2,533 women, between the ages 42 – 52 years, each year over a10-year period. Data was modeled for associations of lean body mass and VMS. Changes in LBM since prior visit and since baseline were also modeled along with differences in means using binary logistic regression, adjusting for covariates.
Results: LBM was significantly associated to concurrent VMS (p = .036), percent change in LBM since prior visit (p = .003), percent change since baseline (p <.001), and overall means associations (p = .023). LBM was not significant for VMS at individual visit measures. In mixed regression modeling, time was significant (p <.0001) at all visits. The estimated probability of developing VMS decreases significantly as LBM increases.
Conclusions: Lean body mass is negatively associated with incident VMS. Our data suggests that maintaining higher levels of LBM during the menopausal transition may be protective against the development of VMS. Every woman will experience menopause in her life and the ability to potentially prevent the onset of specific symptoms through basic interventions, such as resistance training to increase lean body mass, may positively impact this large population.
Keywords
lean body mass, vasomotor symptoms, hot flashes, menopause, women
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CURRENT STATUS: Published
View the published article at Women's Midlife Health.
Version 3
Posted 18 Aug, 2020
No community comments so far
Editorial decision: Accept
On 17 Aug, 2020
Editor assigned
On 13 Aug, 2020
Submission checks complete
On 12 Aug, 2020
Editor invited
On 12 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 19 Jul, 2020
Review #1 received
Received 16 Jul, 2020
Reviewer #1 agreed
On 09 Jul, 2020
Reviewers invited
Invitations sent on 08 Jul, 2020
Editor assigned
On 05 Jul, 2020
Submission checks complete
On 04 Jul, 2020
Editor invited
On 04 Jul, 2020
No comments provided
Review #2 received
Received 11 Jun, 2020
Editorial decision: Major revision
On 11 Jun, 2020
Reviewer #2 agreed
On 27 May, 2020
Review #1 received
Received 21 May, 2020
Reviewer #1 agreed
On 13 May, 2020
Reviewers invited
Invitations sent on 19 Jan, 2020
First submitted
On 13 Jan, 2020
Editor assigned
On 13 Jan, 2020
Submission checks complete
On 12 Jan, 2020
Editor invited
On 12 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
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See the published version of this preprint at Women's Midlife Health.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Rosanne Woods
California University of Pennsylvania
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0717-0702
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Women's Midlife Health.
Version 3
Posted 18 Aug, 2020
No community comments so far
Editorial decision: Accept
On 17 Aug, 2020
Editor assigned
On 13 Aug, 2020
Submission checks complete
On 12 Aug, 2020
Editor invited
On 12 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 19 Jul, 2020
Review #1 received
Received 16 Jul, 2020
Reviewer #1 agreed
On 09 Jul, 2020
Reviewers invited
Invitations sent on 08 Jul, 2020
Editor assigned
On 05 Jul, 2020
Submission checks complete
On 04 Jul, 2020
Editor invited
On 04 Jul, 2020
No comments provided
Review #2 received
Received 11 Jun, 2020
Editorial decision: Major revision
On 11 Jun, 2020
Reviewer #2 agreed
On 27 May, 2020
Review #1 received
Received 21 May, 2020
Reviewer #1 agreed
On 13 May, 2020
Reviewers invited
Invitations sent on 19 Jan, 2020
First submitted
On 13 Jan, 2020
Editor assigned
On 13 Jan, 2020
Submission checks complete
On 12 Jan, 2020
Editor invited
On 12 Jan, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Women's Midlife Health.
Background: The purpose of this study was to examine the association of lean body mass (LBM) to the development of vasomotor symptoms (VMS) as women transition through menopause.
Methods: This study is a secondary use of data available for public use from follow up visits six through 10 for participants in the Study of Women’s Health Across the Nation. The study examined 2,533 women, between the ages 42 – 52 years, each year over a10-year period. Data was modeled for associations of lean body mass and VMS. Changes in LBM since prior visit and since baseline were also modeled along with differences in means using binary logistic regression, adjusting for covariates.
Results: LBM was significantly associated to concurrent VMS (p = .036), percent change in LBM since prior visit (p = .003), percent change since baseline (p <.001), and overall means associations (p = .023). LBM was not significant for VMS at individual visit measures. In mixed regression modeling, time was significant (p <.0001) at all visits. The estimated probability of developing VMS decreases significantly as LBM increases.
Conclusions: Lean body mass is negatively associated with incident VMS. Our data suggests that maintaining higher levels of LBM during the menopausal transition may be protective against the development of VMS. Every woman will experience menopause in her life and the ability to potentially prevent the onset of specific symptoms through basic interventions, such as resistance training to increase lean body mass, may positively impact this large population.
Figure 1
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