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Background: Atrial natriuretic peptide (ANP) refers to a cardiovascular and metabolic hormone that has been identified recently for chronic kidney disease (CKD) without diabetes. Cytokines (e.g., interleukin-6 (IL-6), tumor necrosis element-α (TNF-α) as well as adiponectin (ADP)) contribute to development of diabetes of type 2 (T2DM). The aim here was at investigating ANP and some cytokines extents for a systematic analysis of relationship level in T2DM nephropathy patients.
Methods: Plasma samples from T2DM patients (n=81) in accordance with albuminuria were split into normoalbuminuria (n=37), microalbuminuria (n=23) and macroalbuminuria (n=21), as collected after the consent was received. Based on enzyme-associated immunosorbent test, ANP, TNF-α, IL-6 and ADP in plasma underwent the quantification, and the data received the analysis for determining the correlation between ANP and cytokines among 3 cohorts.
Results: The present study reported that macroalbuminuria patients exhibited higher plasma levels of ANP, TNF-α, IL-6, ADP, serum creatinine (Cr), blood urea nitrogen (BUN) and duration of diabetes mellitus (DM) than the cases subjected to normoalbuminuria and microalbuminuria. Plasma ANP level was significantly associated with TNF-α, IL-6 and ADP, independently of duration of DM and BUN.
Conclusion: Elevated serum ANP levels are likely to impact the metabolism of adipose tissue and inflammation which involved in the pathogenesis and progression of DN.
Keywords
atrial natriuretic peptide, type 2, diabetic nephropathy, albuminuria, cytokines
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CURRENT STATUS: Under Review
Version 1
Posted 02 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 06 Apr, 2021
Review #3 received
Received 03 Apr, 2021
Review #1 received
Received 26 Feb, 2021
Reviewer #3 agreed
On 15 Feb, 2021
Reviewer #2 agreed
On 11 Feb, 2021
Review #2 received
Received 11 Feb, 2021
Reviewers invited
Invitations sent on 10 Feb, 2021
Reviewer #1 agreed
On 10 Feb, 2021
Editor assigned
On 26 Nov, 2020
Submission checks complete
On 26 Nov, 2020
Editor invited
On 26 Nov, 2020
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HTML Views: ...
Subject Areas
Endocrinology & Metabolism
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A new preprint design is coming!
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This preprint is under consideration at BMC Endocrine Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 02 Dec, 2020
No community comments so far
Editorial decision: Major revision
On 06 Apr, 2021
Review #3 received
Received 03 Apr, 2021
Review #1 received
Received 26 Feb, 2021
Reviewer #3 agreed
On 15 Feb, 2021
Reviewer #2 agreed
On 11 Feb, 2021
Review #2 received
Received 11 Feb, 2021
Reviewers invited
Invitations sent on 10 Feb, 2021
Reviewer #1 agreed
On 10 Feb, 2021
Editor assigned
On 26 Nov, 2020
Submission checks complete
On 26 Nov, 2020
Editor invited
On 26 Nov, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Atrial natriuretic peptide (ANP) refers to a cardiovascular and metabolic hormone that has been identified recently for chronic kidney disease (CKD) without diabetes. Cytokines (e.g., interleukin-6 (IL-6), tumor necrosis element-α (TNF-α) as well as adiponectin (ADP)) contribute to development of diabetes of type 2 (T2DM). The aim here was at investigating ANP and some cytokines extents for a systematic analysis of relationship level in T2DM nephropathy patients.
Methods: Plasma samples from T2DM patients (n=81) in accordance with albuminuria were split into normoalbuminuria (n=37), microalbuminuria (n=23) and macroalbuminuria (n=21), as collected after the consent was received. Based on enzyme-associated immunosorbent test, ANP, TNF-α, IL-6 and ADP in plasma underwent the quantification, and the data received the analysis for determining the correlation between ANP and cytokines among 3 cohorts.
Results: The present study reported that macroalbuminuria patients exhibited higher plasma levels of ANP, TNF-α, IL-6, ADP, serum creatinine (Cr), blood urea nitrogen (BUN) and duration of diabetes mellitus (DM) than the cases subjected to normoalbuminuria and microalbuminuria. Plasma ANP level was significantly associated with TNF-α, IL-6 and ADP, independently of duration of DM and BUN.
Conclusion: Elevated serum ANP levels are likely to impact the metabolism of adipose tissue and inflammation which involved in the pathogenesis and progression of DN.
Figure 1
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